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dc.contributor.authorPurrington, Kristen S.
dc.contributor.authorSlettedahl, Seth
dc.contributor.authorBolla, Manjeet K.
dc.contributor.authorMichailidou, Kyriaki
dc.contributor.authorCzene, Kamila
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorBojesen, Stig E.
dc.contributor.authorAndrulis, Irene L.
dc.contributor.authorCox, Angela
dc.contributor.authorHall, Per
dc.contributor.authorCarpenter, Jane
dc.contributor.authorYannoukakos, Drakoulis
dc.contributor.authorHaiman, Christopher A.
dc.contributor.authorFasching, Peter A.
dc.contributor.authorMannermaa, Arto
dc.contributor.authorWinqvist, Robert
dc.contributor.authorBrenner, Hermann
dc.contributor.authorLindblom, Annika
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorBenitez, Javier
dc.contributor.authorSwerdlow, Anthony
dc.contributor.authorKristensen, Vessela
dc.contributor.authorGuénel, Pascal
dc.contributor.authorMeindl, Alfons
dc.contributor.authorDarabi, Hatef
dc.contributor.authorEriksson, Mikael
dc.contributor.authorFagerholm, Rainer
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorNordestgaard, Børge G.
dc.contributor.authorNielsen, Sune F.
dc.contributor.authorFlyger, Henrik
dc.contributor.authorWang, Xianshu
dc.contributor.authorOlswold, Curtis
dc.contributor.authorOlson, Janet E.
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorKnight, Julia A.
dc.contributor.authorTchatchou, Sandrine
dc.contributor.authorReed, Malcolm W.R.
dc.contributor.authorCross, Simon S.
dc.contributor.authorLiu, Jianjun
dc.contributor.authorLi, Jingmei
dc.contributor.authorHumphreys, Keith
dc.contributor.authorClarke, Christine
dc.contributor.authorScott, Rodney
dc.contributor.authorFostira, Florentia
dc.contributor.authorFountzilas, George
dc.contributor.authorKonstantopoulou, Irene
dc.contributor.authorHenderson, Brian E.
dc.contributor.authorSchumacher, Fredrick
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorEkici, Arif B.
dc.contributor.authorHartmann, Arndt
dc.contributor.authorBeckmann, Matthias W.
dc.contributor.authorHartikainen, Jaana M.
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorKataja, Vesa
dc.contributor.authorJukkola-Vuorinen, Arja
dc.contributor.authorPylkäs, Katri
dc.contributor.authorKauppila, Saila
dc.contributor.authorDieffenbach, Aida Karina
dc.contributor.authorStegmaier, Christa
dc.contributor.authorArndt, Volker
dc.contributor.authorMargolin, Sara
dc.contributor.authorBalleine, Rosemary
dc.contributor.authorArias Perez, Jose Ignacio
dc.contributor.authorPilar Zamora, M.
dc.contributor.authorMenéndez, Primitiva
dc.contributor.authorAshworth, Alan
dc.contributor.authorJones, Michael
dc.contributor.authorOrr, Nick
dc.contributor.authorArveux, Patrick
dc.contributor.authorKerbrat, Pierre
dc.contributor.authorTruong, Thérèse
dc.contributor.authorBugert, Peter
dc.contributor.authorToland, Amanda E.
dc.contributor.authorAmbrosone, Christine B.
dc.contributor.authorLabrèche, France
dc.contributor.authorGoldberg, Mark S.
dc.contributor.authorDumont, Martine
dc.contributor.authorZiogas, Argyrios
dc.contributor.authorLee, Eunjung
dc.contributor.authorDite, Gillian S.
dc.contributor.authorApicella, Carmel
dc.contributor.authorSouthey, Melissa C.
dc.contributor.authorLong, Jirong
dc.contributor.authorShrubsole, Martha
dc.contributor.authorDeming-Halverson, Sandra
dc.contributor.authorFicarazzi, Filomena
dc.contributor.authorBarile, Monica
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorDurda, Katarzyna
dc.contributor.authorJaworska-Bieniek, Katarzyna
dc.contributor.authorTollenaar, Robert A.E.M.
dc.contributor.authorSeynaeve, Caroline
dc.contributor.authorBrüning, Thomas
dc.contributor.authorKo, Yon-Dschun
dc.contributor.authorVan Deurzen, Carolien H.M.
dc.contributor.authorMartens, John W.M.
dc.contributor.authorKriege, Mieke
dc.contributor.authorFigueroa, Jonine D.
dc.contributor.authorChanock, Stephen J.
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorTomlinson, Ian
dc.contributor.authorKerin, Michael J.
dc.contributor.authorMiller, Nicola
dc.contributor.authorSchneeweiss, Andreas
dc.contributor.authorTapper, William J.
dc.contributor.authorGerty, Susan M.
dc.contributor.authorDurcan, Lorraine
dc.contributor.authorMclean, Catriona
dc.contributor.authorMilne, Roger L.
dc.contributor.authorBaglietto, Laura
dc.contributor.authordos Santos Silva, Isabel
dc.contributor.authorFletcher, Olivia
dc.contributor.authorJohnson, Nichola
dc.contributor.authorVan'T Veer, Laura J.
dc.contributor.authorCornelissen, Sten
dc.contributor.authorFörsti, Asta
dc.contributor.authorTorres, Diana
dc.contributor.authorRüdiger, Thomas
dc.contributor.authorRudolph, Anja
dc.contributor.authorFlesch-Janys, Dieter
dc.contributor.authorNickels, Stefan
dc.contributor.authorWeltens, Caroline
dc.contributor.authorFloris, Giuseppe
dc.contributor.authorMoisse, Matthieu
dc.contributor.authorDennis, Joe
dc.contributor.authorWang, Qin
dc.contributor.authorDunning, Alison M.
dc.contributor.authorShah, Mitul
dc.contributor.authorBrown, Judith
dc.contributor.authorSimard, Jacques
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorNeuhausen, Susan L.
dc.contributor.authorHopper, John L.
dc.contributor.authorBogdanova, Natalia
dc.contributor.authorDörk, Thilo
dc.contributor.authorZheng, Wei
dc.contributor.authorRadice, Paolo
dc.contributor.authorJakubowska, Anna
dc.contributor.authorLubinski, Jan
dc.contributor.authorDevillee, Peter
dc.contributor.authorBrauch, Hiltrud
dc.contributor.authorHooning, Maartje
dc.contributor.authorGarcía-Closas, Montserrat
dc.contributor.authorSawyer, Elinor
dc.contributor.authorBurwinkel, Barbara
dc.contributor.authorMarmee, Frederick
dc.contributor.authorEccles, Diana M.
dc.contributor.authorGiles, Graham G.
dc.contributor.authorPeto, Julian
dc.contributor.authorSchmidt, Marjanka
dc.contributor.authorBroeks, Annegien
dc.contributor.authorHamann, Ute
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorLambrechts, Diether
dc.contributor.authorPharoah, Paul D.P.
dc.contributor.authorEaston, Douglas
dc.contributor.authorPankratz, V. Shane
dc.contributor.authorSlager, Susan
dc.contributor.authorVachon, Celine M.
dc.contributor.authorCouch, Fergus J.
dc.date.accessioned2018-09-20T16:22:03Z
dc.date.available2018-09-20T16:22:03Z
dc.date.issued2014-06-13
dc.identifier.citationPurrington, Kristen S. Slettedahl, Seth; Bolla, Manjeet K.; Michailidou, Kyriaki; Czene, Kamila; Nevanlinna, Heli; Bojesen, Stig E.; Andrulis, Irene L.; Cox, Angela; Hall, Per; Carpenter, Jane; Yannoukakos, Drakoulis; Haiman, Christopher A.; Fasching, Peter A.; Mannermaa, Arto; Winqvist, Robert; Brenner, Hermann; Lindblom, Annika; Chenevix-Trench, Georgia; Benitez, Javier; Swerdlow, Anthony; Kristensen, Vessela; Guénel, Pascal; Meindl, Alfons; Darabi, Hatef; Eriksson, Mikael; Fagerholm, Rainer; Aittomäki, Kristiina; Blomqvist, Carl; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Wang, Xianshu; Olswold, Curtis; Olson, Janet E.; Mulligan, Anna Marie; Knight, Julia A.; Tchatchou, Sandrine; Reed, Malcolm W.R.; Cross, Simon S.; Liu, Jianjun; Li, Jingmei; Humphreys, Keith; Clarke, Christine; Scott, Rodney; Fostira, Florentia; Fountzilas, George; Konstantopoulou, Irene; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Ekici, Arif B.; Hartmann, Arndt; Beckmann, Matthias W.; Hartikainen, Jaana M.; Kosma, Veli-Matti; Kataja, Vesa; Jukkola-Vuorinen, Arja; Pylkäs, Katri; Kauppila, Saila; Dieffenbach, Aida Karina; Stegmaier, Christa; Arndt, Volker; Margolin, Sara; Balleine, Rosemary; Arias Perez, Jose Ignacio; Pilar Zamora, M.; Menéndez, Primitiva; Ashworth, Alan; Jones, Michael; Orr, Nick; Arveux, Patrick; Kerbrat, Pierre; Truong, Thérèse; Bugert, Peter; Toland, Amanda E.; Ambrosone, Christine B.; Labrèche, France; Goldberg, Mark S.; Dumont, Martine; Ziogas, Argyrios; Lee, Eunjung; Dite, Gillian S.; Apicella, Carmel; Southey, Melissa C.; Long, Jirong; Shrubsole, Martha; Deming-Halverson, Sandra; Ficarazzi, Filomena; Barile, Monica; Peterlongo, Paolo; Durda, Katarzyna; Jaworska-Bieniek, Katarzyna; Tollenaar, Robert A.E.M.; Seynaeve, Caroline; Brüning, Thomas; Ko, Yon-Dschun; Van Deurzen, Carolien H.M.; Martens, John W.M.; Kriege, Mieke; Figueroa, Jonine D.; Chanock, Stephen J.; Lissowska, Jolanta; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Schneeweiss, Andreas; Tapper, William J.; Gerty, Susan M.; Durcan, Lorraine; Mclean, Catriona; Milne, Roger L.; Baglietto, Laura; dos Santos Silva, Isabel; Fletcher, Olivia; Johnson, Nichola; Van'T Veer, Laura J.; Cornelissen, Sten; Försti, Asta; Torres, Diana; Rüdiger, Thomas; Rudolph, Anja; Flesch-Janys, Dieter; Nickels, Stefan; Weltens, Caroline; Floris, Giuseppe; Moisse, Matthieu; Dennis, Joe; Wang, Qin; Dunning, Alison M.; Shah, Mitul; Brown, Judith; Simard, Jacques; Anton-Culver, Hoda; Neuhausen, Susan L.; Hopper, John L.; Bogdanova, Natalia; Dörk, Thilo; Zheng, Wei; Radice, Paolo; Jakubowska, Anna; Lubinski, Jan; Devillee, Peter; Brauch, Hiltrud; Hooning, Maartje; García-Closas, Montserrat; Sawyer, Elinor; Burwinkel, Barbara; Marmee, Frederick; Eccles, Diana M.; Giles, Graham G.; Peto, Julian; Schmidt, Marjanka; Broeks, Annegien; Hamann, Ute; Chang-Claude, Jenny; Lambrechts, Diether; Pharoah, Paul D.P.; Easton, Douglas; Pankratz, V. Shane; Slager, Susan; Vachon, Celine M.; Couch, Fergus J. (2014). Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade. Human Molecular Genetics 23 (22), 6034-6046
dc.identifier.issn0964-6906,1460-2083
dc.identifier.urihttp://hdl.handle.net/10379/13539
dc.description.abstractMitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the Breast Cancer Association Consortium (BCAC) iCOGS study (n = 39 067 cases; n = 42 106 controls). SNPs in TACC2 [rs17550038: odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.16-1.33, P = 4.2 x 10(-10)) and EIF3H (rs799890: OR = 1.07, 95% CI 1.04-1.11, P = 8.7 x 10(-6)) were significantly associated with risk of low-grade breast cancer. The TACC2 signal was retained (rs17550038: OR = 1.15, 95% CI 1.07-1.23, P = 7.9 x 10(-5)) after adjustment for breast cancer risk SNPs in the nearby FGFR2 gene, suggesting that TACC2 is a novel, independent genome-wide significant genetic risk locus for low-grade breast cancer. While no SNPs were individually associated with high-grade disease, a pathway-level gene set analysis showed that variation across the 194 mitotic genes was associated with high-grade breast cancer risk (P = 2.1 x 10(-3)). These observations will provide insight into the contribution of mitotic defects to histological grade and the etiology of breast cancer.
dc.publisherOxford University Press (OUP)
dc.relation.ispartofHuman Molecular Genetics
dc.subjectgenome-wide association
dc.subjectcancer susceptibility loci
dc.subjectprostate-cancer
dc.subjectcell-division
dc.subjectlung-cancer
dc.subjectrisk loci
dc.subjectpolymorphism
dc.subjecttacc2
dc.subjectamplification
dc.subjectprogression
dc.titleGenetic variation in mitotic regulatory pathway genes is associated with breast tumor grade
dc.typeArticle
dc.identifier.doi10.1093/hmg/ddu300
dc.local.publishedsourcehttps://academic.oup.com/hmg/article-pdf/23/22/6034/17260728/ddu300.pdf
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