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The structural and functional role of myelin fast-migrating cerebrosides: pathological importance in multiple sclerosis

dc.contributor.authorPodbielska, Maria
dc.contributor.authorLevery, Steven B
dc.contributor.authorHogan, Edward L
dc.date.accessioned2018-09-20T16:21:47Z
dc.date.available2018-09-20T16:21:47Z
dc.date.issued2011-04-01
dc.identifier.citationPodbielska, Maria; Levery, Steven B; Hogan, Edward L (2011). The structural and functional role of myelin fast-migrating cerebrosides: pathological importance in multiple sclerosis. Clinical Lipidology 6 (2), 159-179
dc.identifier.issn1758-4299
dc.identifier.urihttp://hdl.handle.net/10379/13499
dc.description.abstractA family of neutral glycosphingolipids containing a 3-O-acetyl-sphingosine galactosylceramide (3-SAG) has been characterized. Seven new derivatives of galactosylceramide (GalCer), designated as fast-migrating cerebrosides (FMCs) by TLC retention factor, have been identified. The simplest compounds - FMC-1 and FMC-2 of this series have been characterized as the 3-SAG containing nonhydroxy and hydroxy fatty acyl, respectively. The next two -FMC-3 and FMC-4 - add 6-O-acetyl-galactose and the most complex glycosphingolipids, FMC-5, -6 and -7, are 2,3,4,6-tetra-O-acetyl-3-SAG. These hydrophobic myelin lipid biomarkers coappear with GalCer during myelinogenesis and disappear along with GalCer in de- or dys-myelinating disorders. Myelin lipid antigens, including FMCs, are keys to myelin biology, opening the possibility of new and novel immune modulatory tools for treatment of autoimmune diseases including multiple sclerosis.
dc.publisherFuture Medicine Ltd
dc.relation.ispartofClinical Lipidology
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectanergy
dc.subjectfast-migrating cerebrosides
dc.subjectglycosphingolipids
dc.subjectmultiple sclerosis
dc.subjectmyelin
dc.subjectnkt cells
dc.subjectexperimental autoimmune encephalomyelitis
dc.subjectkiller t-cells
dc.subjectguillain-barre-syndrome
dc.subjectcentral-nervous-system
dc.subjectappearing white-matter
dc.subjectexperimental allergic encephalomyelitis
dc.subjectcirculating antiganglioside antibodies
dc.subjecto-antigenic polysaccharide
dc.subjectlymphoid chemokines ccl19
dc.subjectinvariant nkt cells
dc.titleThe structural and functional role of myelin fast-migrating cerebrosides: pathological importance in multiple sclerosis
dc.typeArticle
dc.identifier.doi10.2217/clp.11.8
dc.local.publishedsourcehttp://europepmc.org/articles/pmc3373471?pdf=render
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland