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dc.contributor.authorPakos‐Zebrucka, Karolina
dc.contributor.authorKoryga, Izabela
dc.contributor.authorMnich, Katarzyna
dc.contributor.authorLjujic, Mila
dc.contributor.authorSamali, Afshin
dc.contributor.authorGorman, Adrienne M.
dc.identifier.citationPakos‐Zebrucka, Karolina; Koryga, Izabela; Mnich, Katarzyna; Ljujic, Mila; Samali, Afshin; Gorman, Adrienne M (2016). The integrated stress response. EMBO reports 17 (10), 1374-1395
dc.description.abstractIn response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2 alpha) by one of four members of the eIF2 alpha kinase family, which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. The gene expression program activated by the ISR optimizes the cellular response to stress and is dependent on the cellular context, as well as on the nature and intensity of the stress stimuli. Although the ISR is primarily a pro-survival, homeostatic program, exposure to severe stress can drive signaling toward cell death. Here, we review current understanding of the ISR signaling and how it regulates cell fate under diverse types of stress.
dc.relation.ispartofEMBO reports
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectactivating transcription factor 4
dc.subjecteif2 alpha kinase
dc.subjecteukaryotic translation initiation factor 2 alpha
dc.subjectintegrated stress response
dc.subjectendoplasmic-reticulum stress
dc.subjectunfolded-protein response
dc.subjectactivating transcription factor-4
dc.subjectinitiation-factor 2
dc.subjectfactor 2-alpha kinase
dc.subjectasparagine synthetase gene
dc.subjectheme-regulated inhibitor
dc.subjectinduced cell-death
dc.subjectfactor 4 atf4
dc.titleThe integrated stress response

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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland