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dc.contributor.authorO'Reilly, M. W.
dc.contributor.authorAvalos, G.
dc.contributor.authorDennedy, M. C.
dc.contributor.authorO'Sullivan, E. P.
dc.contributor.authorDunne, F.
dc.date.accessioned2018-09-20T16:20:29Z
dc.date.available2018-09-20T16:20:29Z
dc.date.issued2011-09-21
dc.identifier.citationO'Reilly, M. W. Avalos, G.; Dennedy, M. C.; O'Sullivan, E. P.; Dunne, F. (2011). Atlantic dip: high prevalence of abnormal glucose tolerance post partum is reduced by breast-feeding in women with prior gestational diabetes mellitus. European Journal of Endocrinology 165 (6), 953-959
dc.identifier.issn0804-4643,1479-683X
dc.identifier.urihttp://hdl.handle.net/10379/13311
dc.description.abstractObjective: Gestational diabetes (GDM) is associated with adverse fetal and maternal outcomes, and identifies women at risk of future type 2 diabetes mellitus (T2DM). Breast-feeding may improve post partum maternal glucose tolerance. Our objective was to identify the prevalence of post partum dysglycemia after GDM, to delineate associated factors and to examine the effect of lactation on post partum glucose tolerance. Design: We compared post partum 75 g oral glucose tolerance test (OGTT) results from 300 women with GDM and 220 controls with normal gestational glucose tolerance (NGT) in five regional centers. Breast-feeding data was collected at time of OGTT. Methods: Post partum OGTT results were classified as normal (fasting plasma glucose (FPG) <5.6 mmol/l, 2 h <7.8 mmol/l) and abnormal (impaired fasting glucose (IFG), FPG 5.6-6.9 mmol/l; impaired glucose tolerance (IGT), 2 h glucose 7.8-11 mmol/l; IFG+IGT; T2DM, FPG >= 7 mmol/l +/- 2 h glucose >= 11.1 mmol/l). Binary logistic regression was used to identify factors predictive of persistent hyperglycemia. Results: Five hundred and twenty women were tested; six (2.7%) with NGT in pregnancy had post partum dysglycemia compared with 57 (19%) with GDM in index pregnancy (P<0.001). Non-European ethnicity (odds ratio (OR) 3.40; 95% confidence interval (CI) 1.45-8.02, P=0.005), family history of T2DM (OR 2.14; 95% CI 1.06-4.32, P=0.034), and gestational insulin use (OR 2.62; 95% CI 1.17-5.87, P=0.019) were associated with persistent dysglycemia. The prevalence of persistent hyperglycemia was significantly lower in women who breast-fed vs bottle-fed post partum (8.2 vs 18.4%, P<0.001). Conclusions: Non-European ethnicity, gestational insulin use, family history of T2DM, and elevated body mass index were associated with persistent dysglycemia after GDM. Breast-feeding may confer beneficial metabolic effects after GDM and should be encouraged.
dc.publisherBioScientifica
dc.relation.ispartofEuropean Journal of Endocrinology
dc.subjectpregnancy
dc.subjectlactation
dc.subjectintolerance
dc.subjectpredictors
dc.subjectmetabolism
dc.subjectduration
dc.subjectoutcomes
dc.subjectdisease
dc.subjecthealth
dc.subjectrisk
dc.titleAtlantic dip: high prevalence of abnormal glucose tolerance post partum is reduced by breast-feeding in women with prior gestational diabetes mellitus
dc.typeArticle
dc.identifier.doi10.1530/eje-11-0663
dc.local.publishedsourcehttp://www.eje-online.org/content/165/6/953.full.pdf
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