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dc.contributor.authorMilne, Roger L.
dc.contributor.authorBurwinkel, Barbara
dc.contributor.authorMichailidou, Kyriaki
dc.contributor.authorArias-Perez, Jose-Ignacio
dc.contributor.authorZamora, M. Pilar
dc.contributor.authorMenéndez-Rodríguez, Primitiva
dc.contributor.authorHardisson, David
dc.contributor.authorMendiola, Marta
dc.contributor.authorGonzález-Neira, Anna
dc.contributor.authorPita, Guillermo
dc.contributor.authorAlonso, M. Rosario
dc.contributor.authorDennis, Joe
dc.contributor.authorWang, Qin
dc.contributor.authorBolla, Manjeet K.
dc.contributor.authorSwerdlow, Anthony
dc.contributor.authorAshworth, Alan
dc.contributor.authorOrr, Nick
dc.contributor.authorSchoemaker, Minouk
dc.contributor.authorKo, Yon-Dschun
dc.contributor.authorBrauch, Hiltrud
dc.contributor.authorHamann, Ute
dc.contributor.authorAndrulis, Irene L.
dc.contributor.authorKnight, Julia A.
dc.contributor.authorGlendon, Gord
dc.contributor.authorTchatchou, Sandrine
dc.contributor.authorMatsuo, Keitaro
dc.contributor.authorIto, Hidemi
dc.contributor.authorIwata, Hiroji
dc.contributor.authorTajima, Kazuo
dc.contributor.authorLi, Jingmei
dc.contributor.authorBrand, Judith S.
dc.contributor.authorBrenner, Hermann
dc.contributor.authorDieffenbach, Aida Karina
dc.contributor.authorArndt, Volker
dc.contributor.authorStegmaier, Christa
dc.contributor.authorLambrechts, Diether
dc.contributor.authorPeuteman, Gilian
dc.contributor.authorChristiaens, Marie-Rose
dc.contributor.authorSmeets, Ann
dc.contributor.authorJakubowska, Anna
dc.contributor.authorLubinski, Jan
dc.contributor.authorJaworska-Bieniek, Katarzyna
dc.contributor.authorDurda, Katazyna
dc.contributor.authorHartman, Mikael
dc.contributor.authorHui, Miao
dc.contributor.authorYen Lim, Wei
dc.contributor.authorWan Chan, Ching
dc.contributor.authorMarme, Federick
dc.contributor.authorYang, Rongxi
dc.contributor.authorBugert, Peter
dc.contributor.authorLindblom, Annika
dc.contributor.authorMargolin, Sara
dc.contributor.authorGarcía-Closas, Montserrat
dc.contributor.authorChanock, Stephen J.
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorFigueroa, Jonine D.
dc.contributor.authorBojesen, Stig E.
dc.contributor.authorNordestgaard, Børge G.
dc.contributor.authorFlyger, Henrik
dc.contributor.authorHooning, Maartje J.
dc.contributor.authorKriege, Mieke
dc.contributor.authorvan den Ouweland, Ans M.W.
dc.contributor.authorKoppert, Linetta B.
dc.contributor.authorFletcher, Olivia
dc.contributor.authorJohnson, Nichola
dc.contributor.authordos-Santos-Silva, Isabel
dc.contributor.authorPeto, Julian
dc.contributor.authorZheng, Wei
dc.contributor.authorDeming-Halverson, Sandra
dc.contributor.authorShrubsole, Martha J.
dc.contributor.authorLong, Jirong
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorRudolph, Anja
dc.contributor.authorSeibold, Petra
dc.contributor.authorFlesch-Janys, Dieter
dc.contributor.authorWinqvist, Robert
dc.contributor.authorPylkäs, Katri
dc.contributor.authorJukkola-Vuorinen, Arja
dc.contributor.authorGrip, Mervi
dc.contributor.authorCox, Angela
dc.contributor.authorCross, Simon S.
dc.contributor.authorReed, Malcolm W.R.
dc.contributor.authorSchmidt, Marjanka K.
dc.contributor.authorBroeks, Annegien
dc.contributor.authorCornelissen, Sten
dc.contributor.authorBraaf, Linde
dc.contributor.authorKang, Daehee
dc.contributor.authorChoi, Ji-Yeob
dc.contributor.authorPark, Sue K.
dc.contributor.authorNoh, Dong-Young
dc.contributor.authorSimard, Jacques
dc.contributor.authorDumont, Martine
dc.contributor.authorGoldberg, Mark S.
dc.contributor.authorLabrèche, France
dc.contributor.authorFasching, Peter A.
dc.contributor.authorHein, Alexander
dc.contributor.authorEkici, Arif B.
dc.contributor.authorBeckmann, Matthias W.
dc.contributor.authorRadice, Paolo
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorAzzollini, Jacopo
dc.contributor.authorBarile, Monica
dc.contributor.authorSawyer, Elinor
dc.contributor.authorTomlinson, Ian
dc.contributor.authorKerin, Michael
dc.contributor.authorMiller, Nicola
dc.contributor.authorHopper, John L.
dc.contributor.authorSchmidt, Daniel F.
dc.contributor.authorMakalic, Enes
dc.contributor.authorSouthey, Melissa C.
dc.contributor.authorHwang Teo, Soo
dc.contributor.authorHar Yip, Cheng
dc.contributor.authorSivanandan, Kavitta
dc.contributor.authorTay, Wan-Ting
dc.contributor.authorShen, Chen-Yang
dc.contributor.authorHsiung, Chia-Ni
dc.contributor.authorYu, Jyh-Cherng
dc.contributor.authorHou, Ming-Feng
dc.contributor.authorGuénel, Pascal
dc.contributor.authorTruong, Therese
dc.contributor.authorSanchez, Marie
dc.contributor.authorMulot, Claire
dc.contributor.authorBlot, William
dc.contributor.authorCai, Qiuyin
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorMuranen, Taru A.
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorWu, Anna H.
dc.contributor.authorTseng, Chiu-Chen
dc.contributor.authorVan Den Berg, David
dc.contributor.authorStram, Daniel O.
dc.contributor.authorBogdanova, Natalia
dc.contributor.authorDörk, Thilo
dc.contributor.authorMuir, Kenneth
dc.contributor.authorLophatananon, Artitaya
dc.contributor.authorStewart-Brown, Sarah
dc.contributor.authorSiriwanarangsan, Pornthep
dc.contributor.authorMannermaa, Arto
dc.contributor.authorKataja, Vesa
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorHartikainen, Jaana M.
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorLu, Wei
dc.contributor.authorGao, Yu-Tang
dc.contributor.authorZhang, Ben
dc.contributor.authorCouch, Fergus J.
dc.contributor.authorToland, Amanda E.
dc.contributor.authorYannoukakos, Drakoulis
dc.contributor.authorSangrajrang, Suleeporn
dc.contributor.authorMcKay, James
dc.contributor.authorWang, Xianshu
dc.contributor.authorOlson, Janet E.
dc.contributor.authorVachon, Celine
dc.contributor.authorPurrington, Kristen
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorBaglietto, Laura
dc.contributor.authorHaiman, Christopher A.
dc.contributor.authorHenderson, Brian E.
dc.contributor.authorSchumacher, Fredrick
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorDevilee, Peter
dc.contributor.authorTollenaar, Robert A.E.M.
dc.contributor.authorSeynaeve, Caroline
dc.contributor.authorCzene, Kamila
dc.contributor.authorEriksson, Mikael
dc.contributor.authorHumphreys, Keith
dc.contributor.authorDarabi, Hatef
dc.contributor.authorAhmed, Shahana
dc.contributor.authorShah, Mitul
dc.contributor.authorPharoah, Paul D.P.
dc.contributor.authorHall, Per
dc.contributor.authorGiles, Graham G.
dc.contributor.authorBenítez, Javier
dc.contributor.authorDunning, Alison M.
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorEaston, Douglas F.
dc.contributor.authorBerchuck, Andrew
dc.contributor.authorEeles, Rosalind A.
dc.contributor.authorOlama, Ali Amin Al
dc.contributor.authorKote-Jarai, Zsofia
dc.contributor.authorBenlloch, Sara
dc.contributor.authorAntoniou, Antonis
dc.contributor.authorMcGuffog, Lesley
dc.contributor.authorOffit, Ken
dc.contributor.authorLee, Andrew
dc.contributor.authorDicks, Ed
dc.contributor.authorLuccarini, Craig
dc.contributor.authorTessier, Daniel C.
dc.contributor.authorBacot, Francois
dc.contributor.authorVincent, Daniel
dc.contributor.authorLaBoissière, Sylvie
dc.contributor.authorRobidoux, Frederic
dc.contributor.authorNielsen, Sune F.
dc.contributor.authorCunningham, Julie M.
dc.contributor.authorWindebank, Sharon A.
dc.contributor.authorHilker, Christopher A.
dc.contributor.authorMeyer, Jeffrey
dc.contributor.authorAngelakos, Maggie
dc.contributor.authorMaskiell, Judi
dc.contributor.authorSchoot, Ellen van der
dc.contributor.authorRutgers, Emiel
dc.contributor.authorVerhoef, Senno
dc.contributor.authorHogervorst, Frans
dc.contributor.authorBoonyawongviroj, Prat
dc.contributor.authorSiriwanarungsan, Pornthep
dc.contributor.authorSchrauder, Michael
dc.contributor.authorRübner, Matthias
dc.contributor.authorOeser, Sonja
dc.contributor.authorLandrith, Silke
dc.contributor.authorWilliams, Eileen
dc.contributor.authorRyder-Mills, Elaine
dc.contributor.authorSargus, Kara
dc.contributor.authorMcInerney, Niall
dc.contributor.authorColleran, Gabrielle
dc.contributor.authorRowan, Andrew
dc.contributor.authorJones, Angela
dc.contributor.authorSohn, Christof
dc.contributor.authorSchneeweiß, Andeas
dc.contributor.authorBugert, Peter
dc.contributor.authorÁlvarez, Núria
dc.contributor.authorLacey, James
dc.contributor.authorWang, Sophia
dc.contributor.authorMa, Huiyan
dc.contributor.authorLu, Yani
dc.contributor.authorDeapen, Dennis
dc.contributor.authorPinder, Rich
dc.contributor.authorLee, Eunjung
dc.contributor.authorSchumacher, Fred
dc.contributor.authorHorn-Ross, Pam
dc.contributor.authorReynolds, Peggy
dc.contributor.authorNelson, David
dc.contributor.authorZiegler, Hartwig
dc.contributor.authorWolf, Sonja
dc.contributor.authorHermann, Volker
dc.contributor.authorLo, Wing-Yee
dc.contributor.authorJustenhoven, Christina
dc.contributor.authorBaisch, Christian
dc.contributor.authorFischer, Hans-Peter
dc.contributor.authorBrüning, Thomas
dc.contributor.authorPesch, Beate
dc.contributor.authorRabstein, Sylvia
dc.contributor.authorLotz, Anne
dc.contributor.authorHarth, Volker
dc.contributor.authorHeikkinen, Tuomas
dc.contributor.authorErkkilä, Irja
dc.contributor.authorAaltonen, Kirsimari
dc.contributor.authorSmitten, Karl von
dc.contributor.authorAntonenkova, Natalia
dc.contributor.authorHillemanns, Peter
dc.contributor.authorChristiansen, Hans
dc.contributor.authorMyöhänen, Eija
dc.contributor.authorKemiläinen, Helena
dc.contributor.authorThorne, Heather
dc.contributor.authorNiedermayr, Eveline
dc.contributor.authorBowtell, D
dc.contributor.authorChenevix-Trench, G
dc.contributor.authordeFazio, A
dc.contributor.authorGertig, D
dc.contributor.authorGreen, A
dc.contributor.authorWebb, P
dc.contributor.authorGreen, A.
dc.contributor.authorParsons, P.
dc.contributor.authorHayward, N.
dc.contributor.authorWebb, P.
dc.contributor.authorWhiteman, D.
dc.contributor.authorFung, Annie
dc.contributor.authorYashiki, June
dc.contributor.authorPeuteman, Gilian
dc.contributor.authorSmeets, Dominiek
dc.contributor.authorBrussel, Thomas Van
dc.contributor.authorCorthouts, Kathleen
dc.contributor.authorObi, Nadia
dc.contributor.authorHeinz, Judith
dc.contributor.authorBehrens, Sabine
dc.contributor.authorEilber, Ursula
dc.contributor.authorCelik, Muhabbet
dc.contributor.authorOlchers, Til
dc.contributor.authorManoukian, Siranoush
dc.contributor.authorPeissel, Bernard
dc.contributor.authorScuvera, Giulietta
dc.contributor.authorZaffaroni, Daniela
dc.contributor.authorBonanni, Bernardo
dc.contributor.authorFeroce, Irene
dc.contributor.authorManiscalco, Angela
dc.contributor.authorRossi, Alessandra
dc.contributor.authorBernard, Loris
dc.contributor.authorTranchant, Martine
dc.contributor.authorValois, Marie-France
dc.contributor.authorTurgeon, Annie
dc.contributor.authorHeguy, Lea
dc.contributor.authorSze Yee, Phuah
dc.contributor.authorKang, Peter
dc.contributor.authorNee, Kang In
dc.contributor.authorMariapun, Shivaani
dc.contributor.authorSook-Yee, Yoon
dc.contributor.authorLee, Daphne
dc.contributor.authorChing, Teh Yew
dc.contributor.authorTaib, Nur Aishah Mohd
dc.contributor.authorOtsukka, Meeri
dc.contributor.authorMononen, Kari
dc.contributor.authorSelander, Teresa
dc.contributor.authorWeerasooriya, Nayana
dc.contributor.authorstaff, OFBCR
dc.contributor.authorKrol-Warmerdam, E.
dc.contributor.authorMolenaar, J.
dc.contributor.authorBlom, J.
dc.contributor.authorBrinton, Louise
dc.contributor.authorSzeszenia-Dabrowska, Neonila
dc.contributor.authorPeplonska, Beata
dc.contributor.authorZatonski, Witold
dc.contributor.authorChao, Pei
dc.contributor.authorStagner, Michael
dc.contributor.authorBos, Petra
dc.contributor.authorBlom, Jannet
dc.contributor.authorCrepin, Ellen
dc.contributor.authorNieuwlaat, Anja
dc.contributor.authorHeemskerk, Annette
dc.contributor.authorHigham, Sue
dc.contributor.authorCross, Simon
dc.contributor.authorCramp, Helen
dc.contributor.authorConnley, Dan
dc.contributor.authorBalasubramanian, Sabapathy
dc.contributor.authorBrock, Ian
dc.contributor.authorLuccarini, Craig
dc.contributor.authorConroy, Don
dc.contributor.authorBaynes, Caroline
dc.contributor.authorChua, Kimberley
dc.date.accessioned2018-09-20T16:17:51Z
dc.date.available2018-09-20T16:17:51Z
dc.date.issued2014-06-18
dc.identifier.citationMilne, Roger L. Burwinkel, Barbara; Michailidou, Kyriaki; Arias-Perez, Jose-Ignacio; Zamora, M. Pilar; Menéndez-Rodríguez, Primitiva; Hardisson, David; Mendiola, Marta; González-Neira, Anna; Pita, Guillermo; Alonso, M. Rosario; Dennis, Joe; Wang, Qin; Bolla, Manjeet K.; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Schoemaker, Minouk; Ko, Yon-Dschun; Brauch, Hiltrud; Hamann, Ute; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Tchatchou, Sandrine; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Tajima, Kazuo; Li, Jingmei; Brand, Judith S.; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Stegmaier, Christa; Lambrechts, Diether; Peuteman, Gilian; Christiaens, Marie-Rose; Smeets, Ann; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katazyna; Hartman, Mikael; Hui, Miao; Yen Lim, Wei; Wan Chan, Ching; Marme, Federick; Yang, Rongxi; Bugert, Peter; Lindblom, Annika; Margolin, Sara; García-Closas, Montserrat; Chanock, Stephen J.; Lissowska, Jolanta; Figueroa, Jonine D.; Bojesen, Stig E.; Nordestgaard, Børge G.; Flyger, Henrik; Hooning, Maartje J.; Kriege, Mieke; van den Ouweland, Ans M.W.; Koppert, Linetta B.; Fletcher, Olivia; Johnson, Nichola; dos-Santos-Silva, Isabel; Peto, Julian; Zheng, Wei; Deming-Halverson, Sandra; Shrubsole, Martha J.; Long, Jirong; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Cox, Angela; Cross, Simon S.; Reed, Malcolm W.R.; Schmidt, Marjanka K.; Broeks, Annegien; Cornelissen, Sten; Braaf, Linde; Kang, Daehee; Choi, Ji-Yeob; Park, Sue K.; Noh, Dong-Young; Simard, Jacques; Dumont, Martine; Goldberg, Mark S.; Labrèche, France; Fasching, Peter A.; Hein, Alexander; Ekici, Arif B.; Beckmann, Matthias W.; Radice, Paolo; Peterlongo, Paolo; Azzollini, Jacopo; Barile, Monica; Sawyer, Elinor; Tomlinson, Ian; Kerin, Michael; Miller, Nicola; Hopper, John L.; Schmidt, Daniel F.; Makalic, Enes; Southey, Melissa C.; Hwang Teo, Soo; Har Yip, Cheng; Sivanandan, Kavitta; Tay, Wan-Ting; Shen, Chen-Yang; Hsiung, Chia-Ni; Yu, Jyh-Cherng; Hou, Ming-Feng; Guénel, Pascal; Truong, Therese; Sanchez, Marie; Mulot, Claire; Blot, William; Cai, Qiuyin; Nevanlinna, Heli; Muranen, Taru A.; Aittomäki, Kristiina; Blomqvist, Carl; Wu, Anna H.; Tseng, Chiu-Chen; Van Den Berg, David; Stram, Daniel O.; Bogdanova, Natalia; Dörk, Thilo; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Shu, Xiao-Ou; Lu, Wei; Gao, Yu-Tang; Zhang, Ben; Couch, Fergus J.; Toland, Amanda E.; Yannoukakos, Drakoulis; Sangrajrang, Suleeporn; McKay, James; Wang, Xianshu; Olson, Janet E.; Vachon, Celine; Purrington, Kristen; Severi, Gianluca; Baglietto, Laura; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Devilee, Peter; Tollenaar, Robert A.E.M.; Seynaeve, Caroline; Czene, Kamila; Eriksson, Mikael; Humphreys, Keith; Darabi, Hatef; Ahmed, Shahana; Shah, Mitul; Pharoah, Paul D.P.; Hall, Per; Giles, Graham G.; Benítez, Javier; Dunning, Alison M.; Chenevix-Trench, Georgia; Easton, Douglas F.; Berchuck, Andrew; Eeles, Rosalind A.; Olama, Ali Amin Al; Kote-Jarai, Zsofia; Benlloch, Sara; Antoniou, Antonis; McGuffog, Lesley; Offit, Ken; Lee, Andrew; Dicks, Ed; Luccarini, Craig; Tessier, Daniel C.; Bacot, Francois; Vincent, Daniel; LaBoissière, Sylvie; Robidoux, Frederic; Nielsen, Sune F.; Cunningham, Julie M.; Windebank, Sharon A.; Hilker, Christopher A.; Meyer, Jeffrey; Angelakos, Maggie; Maskiell, Judi; Schoot, Ellen van der; Rutgers, Emiel; Verhoef, Senno; Hogervorst, Frans; Boonyawongviroj, Prat; Siriwanarungsan, Pornthep; Schrauder, Michael; Rübner, Matthias; Oeser, Sonja; Landrith, Silke; Williams, Eileen; Ryder-Mills, Elaine; Sargus, Kara; McInerney, Niall; Colleran, Gabrielle; Rowan, Andrew; Jones, Angela; Sohn, Christof; Schneeweiß, Andeas; Bugert, Peter; Álvarez, Núria; Lacey, James; Wang, Sophia; Ma, Huiyan; Lu, Yani; Deapen, Dennis; Pinder, Rich; Lee, Eunjung; Schumacher, Fred; Horn-Ross, Pam; Reynolds, Peggy; Nelson, David; Ziegler, Hartwig; Wolf, Sonja; Hermann, Volker; Lo, Wing-Yee; Justenhoven, Christina; Baisch, Christian; Fischer, Hans-Peter; Brüning, Thomas; Pesch, Beate; Rabstein, Sylvia; Lotz, Anne; Harth, Volker; Heikkinen, Tuomas; Erkkilä, Irja; Aaltonen, Kirsimari; Smitten, Karl von; Antonenkova, Natalia; Hillemanns, Peter; Christiansen, Hans; Myöhänen, Eija; Kemiläinen, Helena; Thorne, Heather; Niedermayr, Eveline; Bowtell, D; Chenevix-Trench, G; deFazio, A; Gertig, D; Green, A; Webb, P; Green, A.; Parsons, P.; Hayward, N.; Webb, P.; Whiteman, D.; Fung, Annie; Yashiki, June; Peuteman, Gilian; Smeets, Dominiek; Brussel, Thomas Van; Corthouts, Kathleen; Obi, Nadia; Heinz, Judith; Behrens, Sabine; Eilber, Ursula; Celik, Muhabbet; Olchers, Til; Manoukian, Siranoush; Peissel, Bernard; Scuvera, Giulietta; Zaffaroni, Daniela; Bonanni, Bernardo; Feroce, Irene; Maniscalco, Angela; Rossi, Alessandra; Bernard, Loris; Tranchant, Martine; Valois, Marie-France; Turgeon, Annie; Heguy, Lea; Sze Yee, Phuah; Kang, Peter; Nee, Kang In; Mariapun, Shivaani; Sook-Yee, Yoon; Lee, Daphne; Ching, Teh Yew; Taib, Nur Aishah Mohd; Otsukka, Meeri; Mononen, Kari; Selander, Teresa; Weerasooriya, Nayana; staff, OFBCR; Krol-Warmerdam, E.; Molenaar, J.; Blom, J.; Brinton, Louise; Szeszenia-Dabrowska, Neonila; Peplonska, Beata; Zatonski, Witold; Chao, Pei; Stagner, Michael; Bos, Petra; Blom, Jannet; Crepin, Ellen; Nieuwlaat, Anja; Heemskerk, Annette; Higham, Sue; Cross, Simon; Cramp, Helen; Connley, Dan; Balasubramanian, Sabapathy; Brock, Ian; Luccarini, Craig; Conroy, Don; Baynes, Caroline; Chua, Kimberley (2014). Common non-synonymous snps associated with breast cancer susceptibility: findings from the breast cancer association consortium. Human Molecular Genetics 23 (22), 6096-6111
dc.identifier.issn0964-6906,1460-2083
dc.identifier.urihttp://hdl.handle.net/10379/12900
dc.description.abstractCandidate variant association studies have been largely unsuccessful in identifying common breast cancer susceptibility variants, although most studies have been underpowered to detect associations of a realistic magnitude. We assessed 41 common non-synonymous single-nucleotide polymorphisms (nsSNPs) for which evidence of association with breast cancer risk had been previously reported. Case-control data were combined from 38 studies of white European women (46 450 cases and 42 600 controls) and analyzed using unconditional logistic regression. Strong evidence of association was observed for three nsSNPs: ATXN7-K264R at 3p21 [rs1053338, per allele OR = 1.07, 95% confidence interval (CI) = 1.04-1.10, P = 2.9 x 10 26], AKAP9-M463I at 7q21 (rs6964587, OR = 1.05, 95% CI = 1.03-1.07, P = 1.7 x 10(-6)) and NEK10-L513S at 3p24 (rs10510592, OR = 1.10, 95% CI = 1.07-1.12, P = 5.1 x 10(-17)). The first two associations reached genome-wide statistical significance in a combined analysis of available data, including independent data from nine genome-wide association studies (GWASs): for ATXN7-K264R, OR = 1.07 (95% CI = 1.05-1.10, P = 1.0 x 10(-8)); for AKAP9-M463I, OR = 1.05 (95% CI = 1.04-1.07, P = 2.0 x 10(-10)). Further analysis of other common variants in these two regions suggested that intronic SNPs nearby are more strongly associated with disease risk. We have thus identified a novel susceptibility locus at 3p21, and confirmed previous suggestive evidence that rs6964587 at 7q21 is associated with risk. The third locus, rs10510592, is located in an established breast cancer susceptibility region; the association was substantially attenuated after adjustment for the known GWAS hit. Thus, each of the associated nsSNPs is likely to be a marker for another, non-coding, variant causally related to breast cancer risk. Further fine-mapping and functional studies are required to identify the underlying risk-modifying variants and the genes through which they act.
dc.publisherOxford University Press (OUP)
dc.relation.ispartofHuman Molecular Genetics
dc.subjectgenome-wide association
dc.subjectconfer susceptibility
dc.subjectidentifies 2
dc.subjectrisk
dc.subjectloci
dc.subjectvariants
dc.subjectmetaanalysis
dc.subjectalleles
dc.subject5p12
dc.titleCommon non-synonymous snps associated with breast cancer susceptibility: findings from the breast cancer association consortium
dc.typeArticle
dc.identifier.doi10.1093/hmg/ddu311
dc.local.publishedsourcehttps://academic.oup.com/hmg/article-pdf/23/22/6096/17261146/ddu311.pdf
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