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dc.contributor.authorMichailidou, Kyriaki
dc.contributor.authorHall, Per
dc.contributor.authorGonzalez-Neira, Anna
dc.contributor.authorGhoussaini, Maya
dc.contributor.authorDennis, Joe
dc.contributor.authorMilne, Roger L
dc.contributor.authorSchmidt, Marjanka K
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorBojesen, Stig E
dc.contributor.authorBolla, Manjeet K
dc.contributor.authorWang, Qin
dc.contributor.authorDicks, Ed
dc.contributor.authorLee, Andrew
dc.contributor.authorTurnbull, Clare
dc.contributor.authorRahman, Nazneen
dc.contributor.authorFletcher, Olivia
dc.contributor.authorPeto, Julian
dc.contributor.authorGibson, Lorna
dc.contributor.authordos Santos Silva, Isabel
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorMuranen, Taru A
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorCzene, Kamila
dc.contributor.authorIrwanto, Astrid
dc.contributor.authorLiu, Jianjun
dc.contributor.authorWaisfisz, Quinten
dc.contributor.authorMeijers-Heijboer, Hanne
dc.contributor.authorAdank, Muriel
dc.contributor.authorvan der Luijt, Rob B
dc.contributor.authorHein, Rebecca
dc.contributor.authorDahmen, Norbert
dc.contributor.authorBeckman, Lars
dc.contributor.authorMeindl, Alfons
dc.contributor.authorSchmutzler, Rita K
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorLichtner, Peter
dc.contributor.authorHopper, John L
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorMakalic, Enes
dc.contributor.authorSchmidt, Daniel F
dc.contributor.authorUitterlinden, Andre G
dc.contributor.authorHofman, Albert
dc.contributor.authorHunter, David J
dc.contributor.authorChanock, Stephen J
dc.contributor.authorVincent, Daniel
dc.contributor.authorBacot, François
dc.contributor.authorTessier, Daniel C
dc.contributor.authorCanisius, Sander
dc.contributor.authorWessels, Lodewyk F A
dc.contributor.authorHaiman, Christopher A
dc.contributor.authorShah, Mitul
dc.contributor.authorLuben, Robert
dc.contributor.authorBrown, Judith
dc.contributor.authorLuccarini, Craig
dc.contributor.authorSchoof, Nils
dc.contributor.authorHumphreys, Keith
dc.contributor.authorLi, Jingmei
dc.contributor.authorNordestgaard, Børge G
dc.contributor.authorNielsen, Sune F
dc.contributor.authorFlyger, Henrik
dc.contributor.authorCouch, Fergus J
dc.contributor.authorWang, Xianshu
dc.contributor.authorVachon, Celine
dc.contributor.authorStevens, Kristen N
dc.contributor.authorLambrechts, Diether
dc.contributor.authorMoisse, Matthieu
dc.contributor.authorParidaens, Robert
dc.contributor.authorChristiaens, Marie-Rose
dc.contributor.authorRudolph, Anja
dc.contributor.authorNickels, Stefan
dc.contributor.authorFlesch-Janys, Dieter
dc.contributor.authorJohnson, Nichola
dc.contributor.authorAitken, Zoe
dc.contributor.authorAaltonen, Kirsimari
dc.contributor.authorHeikkinen, Tuomas
dc.contributor.authorBroeks, Annegien
dc.contributor.authorVeer, Laura J Van't
dc.contributor.authorvan der Schoot, C Ellen
dc.contributor.authorGuénel, Pascal
dc.contributor.authorTruong, Thérèse
dc.contributor.authorLaurent-Puig, Pierre
dc.contributor.authorMenegaux, Florence
dc.contributor.authorMarme, Frederik
dc.contributor.authorSchneeweiss, Andreas
dc.contributor.authorSohn, Christof
dc.contributor.authorBurwinkel, Barbara
dc.contributor.authorZamora, M Pilar
dc.contributor.authorPerez, Jose Ignacio Arias
dc.contributor.authorPita, Guillermo
dc.contributor.authorAlonso, M Rosario
dc.contributor.authorCox, Angela
dc.contributor.authorBrock, Ian W
dc.contributor.authorCross, Simon S
dc.contributor.authorReed, Malcolm W R
dc.contributor.authorSawyer, Elinor J
dc.contributor.authorTomlinson, Ian
dc.contributor.authorKerin, Michael J
dc.contributor.authorMiller, Nicola
dc.contributor.authorHenderson, Brian E
dc.contributor.authorSchumacher, Fredrick
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorKnight, Julia A
dc.contributor.authorGlendon, Gord
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorLindblom, Annika
dc.contributor.authorMargolin, Sara
dc.contributor.authorHooning, Maartje J
dc.contributor.authorHollestelle, Antoinette
dc.contributor.authorvan den Ouweland, Ans M W
dc.contributor.authorJager, Agnes
dc.contributor.authorBui, Quang M
dc.contributor.authorStone, Jennifer
dc.contributor.authorDite, Gillian S
dc.contributor.authorApicella, Carmel
dc.contributor.authorTsimiklis, Helen
dc.contributor.authorGiles, Graham G
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorBaglietto, Laura
dc.contributor.authorFasching, Peter A
dc.contributor.authorHaeberle, Lothar
dc.contributor.authorEkici, Arif B
dc.contributor.authorBeckmann, Matthias W
dc.contributor.authorBrenner, Hermann
dc.contributor.authorMüller, Heiko
dc.contributor.authorArndt, Volker
dc.contributor.authorStegmaier, Christa
dc.contributor.authorSwerdlow, Anthony
dc.contributor.authorAshworth, Alan
dc.contributor.authorOrr, Nick
dc.contributor.authorJones, Michael
dc.contributor.authorFigueroa, Jonine
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorBrinton, Louise
dc.contributor.authorGoldberg, Mark S
dc.contributor.authorLabrèche, France
dc.contributor.authorDumont, Martine
dc.contributor.authorWinqvist, Robert
dc.contributor.authorPylkäs, Katri
dc.contributor.authorJukkola-Vuorinen, Arja
dc.contributor.authorGrip, Mervi
dc.contributor.authorBrauch, Hiltrud
dc.contributor.authorHamann, Ute
dc.contributor.authorBrüning, Thomas
dc.contributor.authorRadice, Paolo
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorManoukian, Siranoush
dc.contributor.authorBonanni, Bernardo
dc.contributor.authorDevilee, Peter
dc.contributor.authorTollenaar, Rob A E M
dc.contributor.authorSeynaeve, Caroline
dc.contributor.authorvan Asperen, Christi J
dc.contributor.authorJakubowska, Anna
dc.contributor.authorLubinski, Jan
dc.contributor.authorJaworska, Katarzyna
dc.contributor.authorDurda, Katarzyna
dc.contributor.authorMannermaa, Arto
dc.contributor.authorKataja, Vesa
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorHartikainen, Jaana M
dc.contributor.authorBogdanova, Natalia V
dc.contributor.authorAntonenkova, Natalia N
dc.contributor.authorDörk, Thilo
dc.contributor.authorKristensen, Vessela N
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorSlager, Susan
dc.contributor.authorToland, Amanda E
dc.contributor.authorEdge, Stephen
dc.contributor.authorFostira, Florentia
dc.contributor.authorKang, Daehee
dc.contributor.authorYoo, Keun-Young
dc.contributor.authorNoh, Dong-Young
dc.contributor.authorMatsuo, Keitaro
dc.contributor.authorIto, Hidemi
dc.contributor.authorIwata, Hiroji
dc.contributor.authorSueta, Aiko
dc.contributor.authorWu, Anna H
dc.contributor.authorTseng, Chiu-Chen
dc.contributor.authorVan Den Berg, David
dc.contributor.authorStram, Daniel O
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorLu, Wei
dc.contributor.authorGao, Yu-Tang
dc.contributor.authorCai, Hui
dc.contributor.authorTeo, Soo Hwang
dc.contributor.authorYip, Cheng Har
dc.contributor.authorPhuah, Sze Yee
dc.contributor.authorCornes, Belinda K
dc.contributor.authorHartman, Mikael
dc.contributor.authorMiao, Hui
dc.contributor.authorLim, Wei Yen
dc.contributor.authorSng, Jen-Hwei
dc.contributor.authorMuir, Kenneth
dc.contributor.authorLophatananon, Artitaya
dc.contributor.authorStewart-Brown, Sarah
dc.contributor.authorSiriwanarangsan, Pornthep
dc.contributor.authorShen, Chen-Yang
dc.contributor.authorHsiung, Chia-Ni
dc.contributor.authorWu, Pei-Ei
dc.contributor.authorDing, Shian-Ling
dc.contributor.authorSangrajrang, Suleeporn
dc.contributor.authorGaborieau, Valerie
dc.contributor.authorBrennan, Paul
dc.contributor.authorMcKay, James
dc.contributor.authorBlot, William J
dc.contributor.authorSignorello, Lisa B
dc.contributor.authorCai, Qiuyin
dc.contributor.authorZheng, Wei
dc.contributor.authorDeming-Halverson, Sandra
dc.contributor.authorShrubsole, Martha
dc.contributor.authorLong, Jirong
dc.contributor.authorSimard, Jacques
dc.contributor.authorGarcia-Closas, Montse
dc.contributor.authorPharoah, Paul D P
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorDunning, Alison M
dc.contributor.authorBenitez, Javier
dc.contributor.authorEaston, Douglas F
dc.date.accessioned2018-09-20T16:17:44Z
dc.date.available2018-09-20T16:17:44Z
dc.date.issued2013-03-27
dc.identifier.citationMichailidou, Kyriaki; Hall, Per; Gonzalez-Neira, Anna; Ghoussaini, Maya; Dennis, Joe; Milne, Roger L; Schmidt, Marjanka K; Chang-Claude, Jenny; Bojesen, Stig E; Bolla, Manjeet K; Wang, Qin; Dicks, Ed; Lee, Andrew; Turnbull, Clare; Rahman, Nazneen; Fletcher, Olivia; Peto, Julian; Gibson, Lorna; dos Santos Silva, Isabel; Nevanlinna, Heli; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Czene, Kamila; Irwanto, Astrid; Liu, Jianjun; Waisfisz, Quinten; Meijers-Heijboer, Hanne; Adank, Muriel; van der Luijt, Rob B; Hein, Rebecca; Dahmen, Norbert; Beckman, Lars; Meindl, Alfons; Schmutzler, Rita K; Müller-Myhsok, Bertram; Lichtner, Peter; Hopper, John L; Southey, Melissa C; Makalic, Enes; Schmidt, Daniel F; Uitterlinden, Andre G; Hofman, Albert; Hunter, David J; Chanock, Stephen J; Vincent, Daniel; Bacot, François; Tessier, Daniel C; Canisius, Sander; Wessels, Lodewyk F A; Haiman, Christopher A; Shah, Mitul; Luben, Robert; Brown, Judith; Luccarini, Craig; Schoof, Nils; Humphreys, Keith; Li, Jingmei; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Couch, Fergus J; Wang, Xianshu; Vachon, Celine; Stevens, Kristen N; Lambrechts, Diether; Moisse, Matthieu; Paridaens, Robert; Christiaens, Marie-Rose; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Johnson, Nichola; Aitken, Zoe; Aaltonen, Kirsimari; Heikkinen, Tuomas; Broeks, Annegien; Veer, Laura J Van't; van der Schoot, C Ellen; Guénel, Pascal; Truong, Thérèse; Laurent-Puig, Pierre; Menegaux, Florence; Marme, Frederik; Schneeweiss, Andreas; Sohn, Christof; Burwinkel, Barbara; Zamora, M Pilar; Perez, Jose Ignacio Arias; Pita, Guillermo; Alonso, M Rosario; Cox, Angela; Brock, Ian W; Cross, Simon S; Reed, Malcolm W R; Sawyer, Elinor J; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Henderson, Brian E; Schumacher, Fredrick; Le Marchand, Loic; Andrulis, Irene L; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Lindblom, Annika; Margolin, Sara; Hooning, Maartje J; Hollestelle, Antoinette; van den Ouweland, Ans M W; Jager, Agnes; Bui, Quang M; Stone, Jennifer; Dite, Gillian S; Apicella, Carmel; Tsimiklis, Helen; Giles, Graham G; Severi, Gianluca; Baglietto, Laura; Fasching, Peter A; Haeberle, Lothar; Ekici, Arif B; Beckmann, Matthias W; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Stegmaier, Christa; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Jones, Michael; Figueroa, Jonine; Lissowska, Jolanta; Brinton, Louise; Goldberg, Mark S; Labrèche, France; Dumont, Martine; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Brauch, Hiltrud; Hamann, Ute; Brüning, Thomas; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Bonanni, Bernardo; Devilee, Peter; Tollenaar, Rob A E M; Seynaeve, Caroline; van Asperen, Christi J; Jakubowska, Anna; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Bogdanova, Natalia V; Antonenkova, Natalia N; Dörk, Thilo; Kristensen, Vessela N; Anton-Culver, Hoda; Slager, Susan; Toland, Amanda E; Edge, Stephen; Fostira, Florentia; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Sueta, Aiko; Wu, Anna H; Tseng, Chiu-Chen; Van Den Berg, David; Stram, Daniel O; Shu, Xiao-Ou; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Teo, Soo Hwang; Yip, Cheng Har; Phuah, Sze Yee; Cornes, Belinda K; Hartman, Mikael; Miao, Hui; Lim, Wei Yen; Sng, Jen-Hwei; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Shen, Chen-Yang; Hsiung, Chia-Ni; Wu, Pei-Ei; Ding, Shian-Ling; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Blot, William J; Signorello, Lisa B; Cai, Qiuyin; Zheng, Wei; Deming-Halverson, Sandra; Shrubsole, Martha; Long, Jirong; Simard, Jacques; Garcia-Closas, Montse; Pharoah, Paul D P; Chenevix-Trench, Georgia; Dunning, Alison M; Benitez, Javier; Easton, Douglas F (2013). Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nature Genetics 45 (4), 353-361
dc.identifier.issn1061-4036,1546-1718
dc.identifier.urihttp://hdl.handle.net/10379/12885
dc.description.abstractBreast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for similar to 9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 x 10(-8)). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.
dc.publisherSpringer Nature
dc.relation.ispartofNature Genetics
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectgenome-wide association
dc.subjecthormone-related protein
dc.subjectsusceptibility loci
dc.subjectcommon variants
dc.subjectconfer susceptibility
dc.subjectsignaling pathway
dc.subject14q24.1 rad51l1
dc.subjectgene
dc.subjectconsortium
dc.subjectexpression
dc.titleLarge-scale genotyping identifies 41 new loci associated with breast cancer risk
dc.typeArticle
dc.identifier.doi10.1038/ng.2563
dc.local.publishedsourcehttp://europepmc.org/articles/pmc3771688?pdf=render
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