Large-scale genotyping identifies 41 new loci associated with breast cancer risk
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2013-03-27Author
Michailidou, Kyriaki
Hall, Per
Gonzalez-Neira, Anna
Ghoussaini, Maya
Dennis, Joe
Milne, Roger L
Schmidt, Marjanka K
Chang-Claude, Jenny
Bojesen, Stig E
Bolla, Manjeet K
Wang, Qin
Dicks, Ed
Lee, Andrew
Turnbull, Clare
Rahman, Nazneen
Fletcher, Olivia
Peto, Julian
Gibson, Lorna
dos Santos Silva, Isabel
Nevanlinna, Heli
Muranen, Taru A
Aittomäki, Kristiina
Blomqvist, Carl
Czene, Kamila
Irwanto, Astrid
Liu, Jianjun
Waisfisz, Quinten
Meijers-Heijboer, Hanne
Adank, Muriel
van der Luijt, Rob B
Hein, Rebecca
Dahmen, Norbert
Beckman, Lars
Meindl, Alfons
Schmutzler, Rita K
Müller-Myhsok, Bertram
Lichtner, Peter
Hopper, John L
Southey, Melissa C
Makalic, Enes
Schmidt, Daniel F
Uitterlinden, Andre G
Hofman, Albert
Hunter, David J
Chanock, Stephen J
Vincent, Daniel
Bacot, François
Tessier, Daniel C
Canisius, Sander
Wessels, Lodewyk F A
Haiman, Christopher A
Shah, Mitul
Luben, Robert
Brown, Judith
Luccarini, Craig
Schoof, Nils
Humphreys, Keith
Li, Jingmei
Nordestgaard, Børge G
Nielsen, Sune F
Flyger, Henrik
Couch, Fergus J
Wang, Xianshu
Vachon, Celine
Stevens, Kristen N
Lambrechts, Diether
Moisse, Matthieu
Paridaens, Robert
Christiaens, Marie-Rose
Rudolph, Anja
Nickels, Stefan
Flesch-Janys, Dieter
Johnson, Nichola
Aitken, Zoe
Aaltonen, Kirsimari
Heikkinen, Tuomas
Broeks, Annegien
Veer, Laura J Van't
van der Schoot, C Ellen
Guénel, Pascal
Truong, Thérèse
Laurent-Puig, Pierre
Menegaux, Florence
Marme, Frederik
Schneeweiss, Andreas
Sohn, Christof
Burwinkel, Barbara
Zamora, M Pilar
Perez, Jose Ignacio Arias
Pita, Guillermo
Alonso, M Rosario
Cox, Angela
Brock, Ian W
Cross, Simon S
Reed, Malcolm W R
Sawyer, Elinor J
Tomlinson, Ian
Kerin, Michael J
Miller, Nicola
Henderson, Brian E
Schumacher, Fredrick
Le Marchand, Loic
Andrulis, Irene L
Knight, Julia A
Glendon, Gord
Mulligan, Anna Marie
Lindblom, Annika
Margolin, Sara
Hooning, Maartje J
Hollestelle, Antoinette
van den Ouweland, Ans M W
Jager, Agnes
Bui, Quang M
Stone, Jennifer
Dite, Gillian S
Apicella, Carmel
Tsimiklis, Helen
Giles, Graham G
Severi, Gianluca
Baglietto, Laura
Fasching, Peter A
Haeberle, Lothar
Ekici, Arif B
Beckmann, Matthias W
Brenner, Hermann
Müller, Heiko
Arndt, Volker
Stegmaier, Christa
Swerdlow, Anthony
Ashworth, Alan
Orr, Nick
Jones, Michael
Figueroa, Jonine
Lissowska, Jolanta
Brinton, Louise
Goldberg, Mark S
Labrèche, France
Dumont, Martine
Winqvist, Robert
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Grip, Mervi
Brauch, Hiltrud
Hamann, Ute
Brüning, Thomas
Radice, Paolo
Peterlongo, Paolo
Manoukian, Siranoush
Bonanni, Bernardo
Devilee, Peter
Tollenaar, Rob A E M
Seynaeve, Caroline
van Asperen, Christi J
Jakubowska, Anna
Lubinski, Jan
Jaworska, Katarzyna
Durda, Katarzyna
Mannermaa, Arto
Kataja, Vesa
Kosma, Veli-Matti
Hartikainen, Jaana M
Bogdanova, Natalia V
Antonenkova, Natalia N
Dörk, Thilo
Kristensen, Vessela N
Anton-Culver, Hoda
Slager, Susan
Toland, Amanda E
Edge, Stephen
Fostira, Florentia
Kang, Daehee
Yoo, Keun-Young
Noh, Dong-Young
Matsuo, Keitaro
Ito, Hidemi
Iwata, Hiroji
Sueta, Aiko
Wu, Anna H
Tseng, Chiu-Chen
Van Den Berg, David
Stram, Daniel O
Shu, Xiao-Ou
Lu, Wei
Gao, Yu-Tang
Cai, Hui
Teo, Soo Hwang
Yip, Cheng Har
Phuah, Sze Yee
Cornes, Belinda K
Hartman, Mikael
Miao, Hui
Lim, Wei Yen
Sng, Jen-Hwei
Muir, Kenneth
Lophatananon, Artitaya
Stewart-Brown, Sarah
Siriwanarangsan, Pornthep
Shen, Chen-Yang
Hsiung, Chia-Ni
Wu, Pei-Ei
Ding, Shian-Ling
Sangrajrang, Suleeporn
Gaborieau, Valerie
Brennan, Paul
McKay, James
Blot, William J
Signorello, Lisa B
Cai, Qiuyin
Zheng, Wei
Deming-Halverson, Sandra
Shrubsole, Martha
Long, Jirong
Simard, Jacques
Garcia-Closas, Montse
Pharoah, Paul D P
Chenevix-Trench, Georgia
Dunning, Alison M
Benitez, Javier
Easton, Douglas F
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Michailidou, Kyriaki; Hall, Per; Gonzalez-Neira, Anna; Ghoussaini, Maya; Dennis, Joe; Milne, Roger L; Schmidt, Marjanka K; Chang-Claude, Jenny; Bojesen, Stig E; Bolla, Manjeet K; Wang, Qin; Dicks, Ed; Lee, Andrew; Turnbull, Clare; Rahman, Nazneen; Fletcher, Olivia; Peto, Julian; Gibson, Lorna; dos Santos Silva, Isabel; Nevanlinna, Heli; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Czene, Kamila; Irwanto, Astrid; Liu, Jianjun; Waisfisz, Quinten; Meijers-Heijboer, Hanne; Adank, Muriel; van der Luijt, Rob B; Hein, Rebecca; Dahmen, Norbert; Beckman, Lars; Meindl, Alfons; Schmutzler, Rita K; Müller-Myhsok, Bertram; Lichtner, Peter; Hopper, John L; Southey, Melissa C; Makalic, Enes; Schmidt, Daniel F; Uitterlinden, Andre G; Hofman, Albert; Hunter, David J; Chanock, Stephen J; Vincent, Daniel; Bacot, François; Tessier, Daniel C; Canisius, Sander; Wessels, Lodewyk F A; Haiman, Christopher A; Shah, Mitul; Luben, Robert; Brown, Judith; Luccarini, Craig; Schoof, Nils; Humphreys, Keith; Li, Jingmei; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Couch, Fergus J; Wang, Xianshu; Vachon, Celine; Stevens, Kristen N; Lambrechts, Diether; Moisse, Matthieu; Paridaens, Robert; Christiaens, Marie-Rose; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Johnson, Nichola; Aitken, Zoe; Aaltonen, Kirsimari; Heikkinen, Tuomas; Broeks, Annegien; Veer, Laura J Van't; van der Schoot, C Ellen; Guénel, Pascal; Truong, Thérèse; Laurent-Puig, Pierre; Menegaux, Florence; Marme, Frederik; Schneeweiss, Andreas; Sohn, Christof; Burwinkel, Barbara; Zamora, M Pilar; Perez, Jose Ignacio Arias; Pita, Guillermo; Alonso, M Rosario; Cox, Angela; Brock, Ian W; Cross, Simon S; Reed, Malcolm W R; Sawyer, Elinor J; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Henderson, Brian E; Schumacher, Fredrick; Le Marchand, Loic; Andrulis, Irene L; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Lindblom, Annika; Margolin, Sara; Hooning, Maartje J; Hollestelle, Antoinette; van den Ouweland, Ans M W; Jager, Agnes; Bui, Quang M; Stone, Jennifer; Dite, Gillian S; Apicella, Carmel; Tsimiklis, Helen; Giles, Graham G; Severi, Gianluca; Baglietto, Laura; Fasching, Peter A; Haeberle, Lothar; Ekici, Arif B; Beckmann, Matthias W; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Stegmaier, Christa; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Jones, Michael; Figueroa, Jonine; Lissowska, Jolanta; Brinton, Louise; Goldberg, Mark S; Labrèche, France; Dumont, Martine; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Brauch, Hiltrud; Hamann, Ute; Brüning, Thomas; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Bonanni, Bernardo; Devilee, Peter; Tollenaar, Rob A E M; Seynaeve, Caroline; van Asperen, Christi J; Jakubowska, Anna; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Bogdanova, Natalia V; Antonenkova, Natalia N; Dörk, Thilo; Kristensen, Vessela N; Anton-Culver, Hoda; Slager, Susan; Toland, Amanda E; Edge, Stephen; Fostira, Florentia; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Sueta, Aiko; Wu, Anna H; Tseng, Chiu-Chen; Van Den Berg, David; Stram, Daniel O; Shu, Xiao-Ou; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Teo, Soo Hwang; Yip, Cheng Har; Phuah, Sze Yee; Cornes, Belinda K; Hartman, Mikael; Miao, Hui; Lim, Wei Yen; Sng, Jen-Hwei; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Shen, Chen-Yang; Hsiung, Chia-Ni; Wu, Pei-Ei; Ding, Shian-Ling; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Blot, William J; Signorello, Lisa B; Cai, Qiuyin; Zheng, Wei; Deming-Halverson, Sandra; Shrubsole, Martha; Long, Jirong; Simard, Jacques; Garcia-Closas, Montse; Pharoah, Paul D P; Chenevix-Trench, Georgia; Dunning, Alison M; Benitez, Javier; Easton, Douglas F (2013). Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nature Genetics 45 (4), 353-361
Published Version
Abstract
Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for similar to 9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 x 10(-8)). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.