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dc.contributor.authorMcMahon, Mari
dc.contributor.authorSamali, Afshin
dc.contributor.authorChevet, Eric
dc.date.accessioned2018-09-20T16:17:23Z
dc.date.available2018-09-20T16:17:23Z
dc.date.issued2017-09-01
dc.identifier.citationMcMahon, Mari; Samali, Afshin; Chevet, Eric (2017). Regulation of the unfolded protein response by noncoding rna. American Journal of Physiology-Cell Physiology 313 (3), C243-C254
dc.identifier.issn0363-6143,1522-1563
dc.identifier.urihttp://hdl.handle.net/10379/12829
dc.description.abstractCells are exposed to various intrinsic and extrinsic stresses in both physiological and pathological conditions. To adapt to those conditions, cells have evolved various mechanisms to cope with the disturbances in protein demand, largely through the unfolded protein response (UPR) in the endoplasmic reticulum (ER), but also through the integrated stress response (ISR). Both responses initiate downstream signaling to transcription factors that, in turn, trigger adaptive programs and/or in the case of prolonged stress, cell death mechanisms. Recently, noncoding RNAs, including microRNA and long noncoding RNA, have emerged as key players in the stress responses. These noncoding RNAs act as both regulators and effectors of the UPR and fine-tune the output of the stress signaling pathways. Although much is known about the UPR and the cross talk that exists between pathways, the contribution of small noncoding RNA has not been fully assessed. Herein we bring together and review the current known functions of noncoding RNA in regulating adaptive pathways in both physiological and pathophysiological conditions, illustrating how they operate within the known UPR functions and contribute to diverse cellular outcomes.
dc.publisherAmerican Physiological Society
dc.relation.ispartofAmerican Journal of Physiology-Cell Physiology
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectendoplasmic
dc.subjectnoncoding rna
dc.subjectproteostasis
dc.subjectstress
dc.subjectendoplasmic-reticulum stress
dc.subjecttranscription factor xbp1
dc.subjectmediated messenger-rna
dc.subjectbox-binding protein-1
dc.subjecter-stress
dc.subjectgene-expression
dc.subjectcell-survival
dc.subjectdown-regulation
dc.subjecthepatocellular-carcinoma
dc.subjectmicrorna biogenesis
dc.titleRegulation of the unfolded protein response by noncoding rna
dc.typeArticle
dc.identifier.doi10.1152/ajpcell.00293.2016
dc.local.publishedsourcehttps://hal-univ-rennes1.archives-ouvertes.fr/hal-01586174/file/McMahon-Regulation%20of%20the%20Unfolded%20Protein-Accepted.pdf
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland