Show simple item record

dc.contributor.authorMcGrath, E. R.
dc.contributor.authorKapral, M. K.
dc.contributor.authorFang, J.
dc.contributor.authorEikelboom, J. W.
dc.contributor.authorConghaile, A. o.
dc.contributor.authorCanavan, M.
dc.contributor.authorO'Donnell, M. J.
dc.contributor.author,
dc.date.accessioned2018-09-20T16:17:09Z
dc.date.available2018-09-20T16:17:09Z
dc.date.issued2012-05-22
dc.identifier.citationMcGrath, E. R. Kapral, M. K.; Fang, J.; Eikelboom, J. W.; Conghaile, A. o.; Canavan, M.; O'Donnell, M. J.; , (2012). Which risk factors are more associated with ischemic stroke than intracerebral hemorrhage in patients with atrial fibrillation?. Stroke 43 (8), 2048-U76
dc.identifier.issn0039-2499,1524-4628
dc.identifier.urihttp://hdl.handle.net/10379/12795
dc.description.abstractBackground and Purpose-The decision to prescribe oral anticoagulant therapy in patients with atrial fibrillation is based on an assessment of the competing risks of ischemic stroke and major bleeding, of which intracerebral hemorrhage (ICH) is the most important type. We sought to determine the comparative importance of risk factors for ischemic stroke and ICH in patients with acute stroke and atrial fibrillation with particular emphasis on risk factors common to both stroke types. Methods-Consecutive patients with acute ischemic stroke or ICH and atrial fibrillation included in the Registry of the Canadian Stroke Network constituted the cohort. Multivariable logistic regression analysis was used to determine the association between baseline risk factors and presentation with ICH versus ischemic stroke. Risk factors included: (1) those previously reported to be risk factors for both ischemic stroke and major bleeding (particularly ICH) ("shared" risk factors, including age, alcohol, hypertension, diabetes mellitus, renal impairment, prior stroke/transient ischemic attack and preadmission dementia); and (2) other risk factors associated with either stroke subtype alone. Results-A total of 3197 patients presented with atrial fibrillation and acute stroke, of which 12.2% presented with ICH. Of the "shared" risk factors, age (OR, 1.19; 95% CI, 1.06-1.34 per decade) and prior stroke/transient ischemic attack (OR, 1.45; 95% CI, 1.12-1.87) were more associated with ischemic stroke than ICH, whereas a history of hypertension (OR, 0.89; 95% CI, 0.68-1.17), diabetes mellitus (OR 1.23; 95% CI, 0.92-1.64), renal impairment (OR, 1.28; 95% CI, 0.95-1.71), and alcohol intake were not more strongly associated with either stroke subtype. Conclusion-Of the risk factors known to be associated with both ischemic stroke and ICH in patients with atrial fibrillation, we found that none had a stronger association with ICH. Older age was more strongly associated with ischemic stroke than ICH. (Stroke. 2012;43:2048-2054.)
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.ispartofStroke
dc.subjectatrial fibrillation
dc.subjectrisk factors
dc.subjectstroke
dc.subjectclinical classification schemes
dc.subjectoral anticoagulant-therapy
dc.subjectpredicting stroke
dc.subjectintracranial hemorrhage
dc.subjectgender-differences
dc.subjectnational registry
dc.subjectaspirin therapy
dc.subjectblood-pressure
dc.subjectbleeding risk
dc.subjectwarfarin
dc.titleWhich risk factors are more associated with ischemic stroke than intracerebral hemorrhage in patients with atrial fibrillation?
dc.typeArticle
dc.identifier.doi10.1161/strokeaha.112.654145
dc.local.publishedsourcehttps://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.112.654145
nui.item.downloads0


Files in this item

This item appears in the following Collection(s)

Show simple item record