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dc.contributor.authorMcGonagle, Dennis
dc.contributor.authorTan, Ai Lyn
dc.contributor.authorCarey, John
dc.contributor.authorBenjamin, Michael
dc.date.accessioned2018-09-20T16:17:07Z
dc.date.available2018-09-20T16:17:07Z
dc.date.issued2010-03-01
dc.identifier.citationMcGonagle, Dennis; Tan, Ai Lyn; Carey, John; Benjamin, Michael (2010). The anatomical basis for a novel classification of osteoarthritis and allied disorders. Journal of Anatomy 216 (3), 279-291
dc.identifier.issn0021-8782,1469-7580
dc.identifier.urihttp://hdl.handle.net/10379/12789
dc.description.abstractOsteoarthritis (OA) has historically been classified as 'primary' where no discernible cause was evident and 'secondary' where a triggering factor was apparent. Irrespective of the triggering events, late-stage OA is usually characterized by articular cartilage attrition and consequently the anatomical basis for disease has been viewed in terms of cartilage. However, the widespread application of magnetic resonance imaging in early OA has confirmed several different anatomical abnormalities within diseased joints. A key observation has been that several types of primary or idiopathic OA show ligament-related pathology at the time of clinical presentation, so these categories of disease are no longer idiopathic - at least from the anatomical perspective. There is also ample evidence for OA initiation in other structures including menisci and bones in addition to articular cartilage. Therefore, a new classification for OA is proposed, which is based on the anatomical sites of earliest discernible joint structural involvement. The major proposed subgroups within this classification are ligament-, cartilage-, bone-, meniscal- and synovial-related, in addition to disease that is mixed pattern or multifocal in origin. We show how such a structural classification for OA provides a useful reference framework for staging the magnitude of disease. For late-stage or end-stage/whole organ disease, the final common pathway of these different scenarios, joint replacement strategies are likely to remain the only viable option. However, for younger subjects in particular, near the time of clinical disease onset, this scheme has implications for therapy targeted to specific anatomical locations. Thus, in the same way that tumours can be classified and staged according to their tissue of origin and extent of involvement, OA can likewise be anatomically classified and staged. This has implications for therapeutic strategies including regenerative medicine therapy development. Key words bone; cartilage; classification; ligaments; osteoarthritis.
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Anatomy
dc.subjectbone
dc.subjectcartilage
dc.subjectclassification
dc.subjectligaments
dc.subjectosteoarthritis
dc.subjectsymptomatic knee osteoarthritis
dc.subjectmesenchymal stem-cells
dc.subjectbone-marrow edema
dc.subjectarticular-cartilage
dc.subjecthand osteoarthritis
dc.subjectsubchondral bone
dc.subjectglycosaminoglycan content
dc.subjectpsoriatic-arthritis
dc.subjectjoint destruction
dc.subjectimaging findings
dc.titleThe anatomical basis for a novel classification of osteoarthritis and allied disorders
dc.typeArticle
dc.identifier.doi10.1111/j.1469-7580.2009.01186.x
dc.local.publishedsourcehttp://onlinelibrary.wiley.com/doi/10.1111/j.1469-7580.2009.01186.x/pdf
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