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dc.contributor.authorMcGinley, Lisa M.
dc.contributor.authorMcMahon, Jill
dc.contributor.authorStocca, Alessia
dc.contributor.authorDuffy, Aoife
dc.contributor.authorFlynn, Aidan
dc.contributor.authorO'Toole, Daniel
dc.contributor.authorO'Brien, Timothy
dc.identifier.citationMcGinley, Lisa M. McMahon, Jill; Stocca, Alessia; Duffy, Aoife; Flynn, Aidan; O'Toole, Daniel; O'Brien, Timothy (2013). Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression. Human Gene Therapy 24 (10), 840-851
dc.description.abstractMesenchymal stem cell (MSC) therapy offers the potential to promote recovery after myocardial infarction (MI). However, therapeutic efficacy may be limited by poor survival and retention of transplanted cells. A combination of gene and cell therapy has the capacity to prevent donor cell death and augment the reparative and regenerative effects of cell transfer. The present study investigates the effect of exogenous heat shock protein 27 (Hsp27) expression in MSCs in an in vitro model of ischemia and in an in vivo rat MI model and aims to determine if this could enhance the therapeutic benefit associated with cell delivery. Hsp27 overexpression by lentivirus vector modification resulted in increased MSC survival in vitro and in vivo. Furthermore, decreased apoptosis in the infarcted tissue and improved cardiac function was observed in the Hsp27 group, enhancing the therapeutic effect of MSCs. Together, these data demonstrate that ex vivo genetic modificationspecifically Hsp27 overexpressionoffers the possibility of enhancing the efficacy of MSC therapy in MI.
dc.publisherMary Ann Liebert Inc
dc.relation.ispartofHuman Gene Therapy
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectacute myocardial-infarction
dc.subjectmarrow stromal cells
dc.subjectcardiac repair
dc.subjectprogenitor cells
dc.titleMesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression

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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland