Show simple item record

dc.contributor.authorMc Cormack, O
dc.contributor.authorChung, W Y
dc.contributor.authorFitzpatrick, P
dc.contributor.authorCooke, F
dc.contributor.authorFlynn, B
dc.contributor.authorHarrison, M
dc.contributor.authorFox, E
dc.contributor.authorGallagher, E
dc.contributor.authorGoldrick, A Mc
dc.contributor.authorDervan, P A
dc.contributor.authorMc Cann, A
dc.contributor.authorKerin, M J
dc.identifier.citationMc Cormack, O; Chung, W Y; Fitzpatrick, P; Cooke, F; Flynn, B; Harrison, M; Fox, E; Gallagher, E; Goldrick, A Mc; Dervan, P A; Mc Cann, A; Kerin, M J (2008). Growth arrest-specific gene 6 expression in human breast cancer. British Journal of Cancer 98 (6), 1141-1146
dc.description.abstractGrowth arrest- specific gene 6 ( Gas6), identified in 1995, acts as the ligand to the Axl/ Tyro3 family of tyrosine kinase receptors and exerts mitogenic activity when bound to these receptors. Overexpression of the Axl/ Tyro3 receptor family has been found in breast, ovarian and lung tumours. Gas6 is upregulated 23- fold by progesterone acting through the progesterone receptor B ( PRB). Recently, Gas6 has been shown to be a target for overexpression and amplification in breast cancer. Quantitative real- time PCR analysis was used to determine the levels of Gas6 mRNA expression in 49 primary breast carcinomas. Expression of PRB protein was evaluated immunohistochemically with a commercially available PRB antibody. The results showed a positive association between PRB protein and Gas6 mRNA levels ( P =0.04). Gas6 correlated positively with a number of favourable prognostic variables including lymph node negativity ( P =0.0002), younger age at diagnosis ( P =0.04), smaller size of tumours ( P =0.02), low Nottingham prognostic index scores ( P =0.03) and low nuclear morphology ( P =0.03). This study verifies for the first time the association between PRB and Gas6 in breast cancer tissue.
dc.publisherSpringer Nature
dc.relation.ispartofBritish Journal of Cancer
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectgrowth arrest-specific gene 6
dc.subjectaxl tyrosine kinase receptor
dc.subjectprogesterone receptor b
dc.subjectbreast cancer
dc.subjecttyrosine kinase receptor
dc.subjectarrest-specific gene-6
dc.subjectgas6 receptors
dc.subjectaxl receptor
dc.titleGrowth arrest-specific gene 6 expression in human breast cancer

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland