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dc.contributor.authorMatchett, Kyle
dc.contributor.authorLynam-Lennon, Niamh
dc.contributor.authorWatson, R.
dc.contributor.authorBrown, James
dc.date.accessioned2018-09-20T16:16:18Z
dc.date.available2018-09-20T16:16:18Z
dc.date.issued2017-10-25
dc.identifier.citationMatchett, Kyle; Lynam-Lennon, Niamh; Watson, R. Brown, James (2017). Advances in precision medicine: tailoring individualized therapies. Cancers 9 (11),
dc.identifier.issn2072-6694
dc.identifier.urihttp://hdl.handle.net/10379/12682
dc.description.abstractThe traditional bench-to-bedside pipeline involves using model systems and patient samples to provide insights into pathways deregulated in cancer. This discovery reveals new biomarkers and therapeutic targets, ultimately stratifying patients and informing cohort-based treatment options. Precision medicine (molecular profiling of individual tumors combined with established clinical-pathological parameters) reveals, in real-time, individual patient's diagnostic and prognostic risk profile, informing tailored and tumor-specific treatment plans. Here we discuss advances in precision medicine presented at the Irish Association for Cancer Research Annual Meeting, highlighting examples where personalized medicine approaches have led to precision discovery in individual tumors, informing customized treatment programs.
dc.publisherMDPI AG
dc.relation.ispartofCancers
dc.subjectireland cancer meeting
dc.subjectpersonalized
dc.subjectpdx
dc.subjectavatar
dc.subjectprecision medicine
dc.subjectprofiling
dc.subjectxenografts
dc.subjectpatient-derived xenografts
dc.subjectprostate-cancer
dc.subjectbreast-cancer
dc.subjecttumor xenografts
dc.subjectsolid tumors
dc.subjectneuroblastoma
dc.subjectevolution
dc.subjectresponses
dc.subjectchildren
dc.subjectmetastasis
dc.titleAdvances in precision medicine: tailoring individualized therapies
dc.typeArticle
dc.identifier.doi10.3390/cancers9110146
dc.local.publishedsourcehttp://www.mdpi.com/2072-6694/9/11/146/pdf
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