Show simple item record

dc.contributor.authorKharabi Masouleh, Behzad
dc.contributor.authorChevet, Eric
dc.contributor.authorPanse, Jens
dc.contributor.authorJost, Edgar
dc.contributor.authorO’Dwyer, Michael
dc.contributor.authorBruemmendorf, Tim H.
dc.contributor.authorSamali, Afshin
dc.identifier.citationKharabi Masouleh, Behzad; Chevet, Eric; Panse, Jens; Jost, Edgar; O’Dwyer, Michael; Bruemmendorf, Tim H. Samali, Afshin (2015). Drugging the unfolded protein response in acute leukemias. Journal of Hematology & Oncology 8 ,
dc.description.abstractThe unfolded protein response (UPR), an endoplasmic reticulum (ER) stress-induced signaling cascade, is mediated by three major stress sensors IRE-1 alpha, PERK, and ATF6 alpha. Studies described the UPR as a critical network in selection, adaptation, and survival of cancer cells. While previous reviews focused mainly on solid cancer cells, in this review, we summarize the recent findings focusing on acute leukemias. We take into account the impact of the underlying genetic alterations of acute leukemia cells, the leukemia stem cell pool, and provide an outline on the current genetic, clinical, and therapeutic findings. Furthermore, we shed light on the important oncogene-specific regulation of individual UPR signaling branches and the therapeutic relevance of this information to answer the question if the UPR could be an attractive novel target in acute leukemias.
dc.publisherSpringer Nature
dc.relation.ispartofJournal of Hematology & Oncology
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectacute myeloid leukemia
dc.subjectacute lymphoblastic leukemia
dc.subjectleukemia stem cells
dc.subjectunfolded protein response
dc.subjectsmall-molecule inhibitors
dc.subjectacute myeloid-leukemia
dc.subjectendoplasmic-reticulum stress
dc.subjectacute lymphoblastic-leukemia
dc.subjectacute promyelocytic leukemia
dc.subjectacute myelogenous leukemia
dc.subjectxbp1 messenger-rna
dc.subjectinduced cell-death
dc.subjectcancer stem-cells
dc.subjecter stress
dc.titleDrugging the unfolded protein response in acute leukemias

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland