Show simple item record

dc.contributor.authorMariotti, Letizia
dc.contributor.authorDevaney, Nicholas
dc.contributor.authorLombardo, Giuseppe
dc.contributor.authorLombardo, Marco
dc.identifier.citationMariotti, Letizia; Devaney, Nicholas; Lombardo, Giuseppe; Lombardo, Marco (2017). Analysis of cone mosaic reflectance properties in healthy eyes and in eyes with nonproliferative diabetic retinopathy over time. Investigative Opthalmology & Visual Science 58 (10), 4057-4067
dc.description.abstractPURPOSE. We investigate the reflectance properties of the cone mosaic in adaptive optics (AO) images of healthy subjects and subjects with nonproliferative diabetic retinopathy (NPDR) over time. METHODS. We acquired images of the parafoveal cone mosaic over 5 years in 12 healthy subjects and in six patients with mild NPDR. We analyzed the parameters of the cone intensity histogram distribution (mean, SD, and skewness), two metrics of the cone mosaic texture (sharpness and entropy), and two novel metrics (cone/intercone intensity and slope of the variogram). Each metric was calculated on the same four retinal locations (200 X 200 mu m areas, 2 degrees from the fovea along the four meridians) over dine for each subject. RESULTS. The histogram distributions of cone intensities were similar between the two study groups. However, the cone/intercone intensity, slope of the variograms and entropy showed a significant difference between healthy and NPDR subjects (P = 0.036, P = 0.002, P = 0.014, respectively). All parameters, except for mean cone intensity did not change with time in this study CONCLUSIONS. We observed significant differences in cone mosaic reflectance properties between healthy eyes and eyes with NPDR, in its spatial organization and in its intensity especially between directional and nondirectional backscattering. We introduced a novel method for the study of the spatial distribution of cone reflectance, the variogram, which was able to quantify differences of the spatial dependence of cone intensities over a short range between NPDR and healthy eyes.
dc.publisherAssociation for Research in Vision and Ophthalmology (ARVO)
dc.relation.ispartofInvestigative Opthalmology & Visual Science
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectcone reflectance
dc.subjectdiabetic retinopathy
dc.subjectadaptive optics
dc.subjectscanning laser ophthalmoscopy
dc.subjectparafoveal cones
dc.subjectretinal images
dc.titleAnalysis of cone mosaic reflectance properties in healthy eyes and in eyes with nonproliferative diabetic retinopathy over time

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland