dc.contributor.author | Magee, David A. | |
dc.contributor.author | Berry, Donagh P. | |
dc.contributor.author | Berkowicz, Erik W. | |
dc.contributor.author | Sikora, Klaudia M. | |
dc.contributor.author | Howard, Dawn J. | |
dc.contributor.author | Mullen, Michael P. | |
dc.contributor.author | Evans, Ross D. | |
dc.contributor.author | Spillane, Charles | |
dc.contributor.author | MacHugh, David E. | |
dc.date.accessioned | 2018-09-20T16:15:29Z | |
dc.date.available | 2018-09-20T16:15:29Z | |
dc.date.issued | 2010-09-03 | |
dc.identifier.citation | Magee, David A. Berry, Donagh P.; Berkowicz, Erik W.; Sikora, Klaudia M.; Howard, Dawn J.; Mullen, Michael P.; Evans, Ross D.; Spillane, Charles; MacHugh, David E. (2010). Single nucleotide polymorphisms within the bovine dlk1-dio3 imprinted domain are associated with economically important production traits in cattle. Journal of Heredity 102 (1), 94-101 | |
dc.identifier.issn | 1465-7333,0022-1503 | |
dc.identifier.uri | http://hdl.handle.net/10379/12576 | |
dc.description.abstract | Previous studies show that DNA sequence variation within the mammalian DLK1-DIO3 imprinted domain influences production traits in domestic livestock, most notably the ovine callipyge phenotype. We assessed genotype-phenotype associations between 7 single nucleotide polymorphisms (SNPs) within the orthologous bovine DLK1-DIO3 domain and performance traits in 848 progeny-tested Holstein-Friesian dairy sires. One SNP (MEG3_01) located proximal to the maternally expressed 3 (MEG3/Gtl2) gene was associated with milk yield, subcutaneous fat levels, and progeny carcass conformation (P < 0.01) and also tended to be associated with milk fat and protein yield (P < 0.10). A single SNP (CLPG_01) within the putative CLPG1 locus was associated with progeny carcass fat (P < 0.05), whereas a single SNP (PEG11_01) located proximal to the paternally expressed 11 (PEG11/Rtl) gene was associated with progeny carcass weight (P < 0.05). The MEG3_01 SNP together with an additional 2 SNPs (MEG8_01 and MEG8_02) located proximal to the putative maternally expressed 8 (MEG8/Rian) ortholog were associated (P < 0.05) with perinatal mortality. Finally, one SNP (MEG3_03) was associated (P < 0.05) with gestation length, whereas both the CLPG_01 and MEG8_01 SNPs also tended to be associated with calving interval (P < 0.10). Linkage disequilibrium analysis suggests that some phenotypic associations observed at these loci are independent. To our knowledge, this is one of the first studies demonstrating associations between the bovine DLK1-DIO3 domain and milk, carcass, fertility and, health traits in cattle. This imprinted domain may serve as a potential target for future genetic selection strategies. | |
dc.publisher | Oxford University Press (OUP) | |
dc.relation.ispartof | Journal of Heredity | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | association | |
dc.subject | bos | |
dc.subject | callipyge | |
dc.subject | dlk1-dio3 domain | |
dc.subject | genetic imprinting | |
dc.subject | single nucleotide polymorphism | |
dc.subject | ovine callipyge locus | |
dc.subject | carcass traits | |
dc.subject | polar overdominance | |
dc.subject | muscle hypertrophy | |
dc.subject | trans-interaction | |
dc.subject | igf2 | |
dc.subject | expression | |
dc.subject | phenotype | |
dc.subject | mutation | |
dc.subject | growth | |
dc.title | Single nucleotide polymorphisms within the bovine dlk1-dio3 imprinted domain are associated with economically important production traits in cattle | |
dc.type | Article | |
dc.identifier.doi | 10.1093/jhered/esq097 | |
dc.local.publishedsource | https://academic.oup.com/jhered/article-pdf/102/1/94/14115583/esq097.pdf | |
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