Characterizing protein modifications by reactive metabolites using magnetic bead bioreactors and lc-ms/ms
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2015-01-01Author
Li, Dandan
Fu, You-Jun
Rusling, James F.
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Li, Dandan; Fu, You-Jun; Rusling, James F. (2015). Characterizing protein modifications by reactive metabolites using magnetic bead bioreactors and lc-ms/ms. Chem. Commun. 51 (22), 4701-4703
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Abstract
We report here label-free metabolite-protein adduct detection and identification employing magnetic beads coated with metabolic enzymes as bioreactors to generate metabolites and possible metabolite-protein adducts for analysis by liquid chromatographytandem mass spectrometry.