Structure elucidation and in vitro toxicity of new azaspiracids isolated from the marine dinoflagellate azadinium poporum
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2015-10-30Author
Krock, Bernd
Tillmann, Urban
Potvin, Éric
Jeong, Hae
Drebing, Wolfgang
Kilcoyne, Jane
Al-Jorani, Ahmed
Twiner, Michael
Göthel, Qun
Köck, Matthias
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Krock, Bernd; Tillmann, Urban; Potvin, Éric; Jeong, Hae; Drebing, Wolfgang; Kilcoyne, Jane; Al-Jorani, Ahmed; Twiner, Michael; Göthel, Qun; Köck, Matthias (2015). Structure elucidation and in vitro toxicity of new azaspiracids isolated from the marine dinoflagellate azadinium poporum. Marine Drugs 13 (11), 6687-6702
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Abstract
Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structures were determined to be 3-hydroxy-8-methyl-39-demethyl-azaspiracid-1 (1) and 3-hydroxy-7,8-dihydro-39-demethyl-azaspiracid-1 (2) by H-1- and C-13-NMR. Using the Jurkat T lymphocyte cell toxicity assay, (1) and (2) were found to be 6- and 3-fold less toxic than AZA-1, respectively.