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dc.contributor.authorKirwan, Alan
dc.contributor.authorUtratna, Marta
dc.contributor.authorO’Dwyer, Michael E.
dc.contributor.authorJoshi, Lokesh
dc.contributor.authorKilcoyne, Michelle
dc.date.accessioned2018-09-20T16:13:19Z
dc.date.available2018-09-20T16:13:19Z
dc.date.issued2015-01-01
dc.identifier.citationKirwan, Alan; Utratna, Marta; O’Dwyer, Michael E. Joshi, Lokesh; Kilcoyne, Michelle (2015). Glycosylation-based serum biomarkers for cancer diagnostics and prognostics. BioMed Research International ,
dc.identifier.issn2314-6133,2314-6141
dc.identifier.urihttp://hdl.handle.net/10379/12283
dc.description.abstractCancer is the second most common cause of death in developed countries with approximately 14 million newly diagnosed individuals and over 6 million cancer-related deaths in 2012. Many cancers are discovered at a more advanced stage but better survival rates are correlated with earlier detection. Current clinically approved cancer biomarkers are most effective when applied to patients with widespread cancer. Single biomarkers with satisfactory sensitivity and specificity have not been identified for the most common cancers and some biomarkers are ineffective for the detection of early stage cancers. Thus, novel biomarkers with better diagnostic and prognostic performance are required. Aberrant protein glycosylation is well known hallmark of cancer and represents a promising source of potential biomarkers. Glycoproteins enter circulation from tissues or blood cells through active secretion or leakage and patient serum is an attractive option as a source for biomarkers from a clinical and diagnostic perspective. A plethora of technical approaches have been developed to address the challenges of glycosylation structure detection and determination. This review summarises currently utilised glycoprotein biomarkers and novel glycosylation-based biomarkers from the serum glycoproteome under investigation as cancer diagnostics and for monitoring and prognostics and includes details of recent high throughput and other emerging glycoanalytical techniques.
dc.publisherHindawi Limited
dc.relation.ispartofBioMed Research International
dc.subjectprostate-specific antigen
dc.subjectreactive alpha-fetoprotein
dc.subjecthepatocellular-carcinoma patients
dc.subjecthuman chorionic-gonadotropin
dc.subjectepithelial ovarian-cancer
dc.subjectepididymis protein 4
dc.subjectgestational trophoblastic disease
dc.subjectelectrospray mass-spectrometry
dc.subjectmultiple-myeloma patients
dc.subjectepidermal-growth-factor
dc.titleGlycosylation-based serum biomarkers for cancer diagnostics and prognostics
dc.typeArticle
dc.identifier.doi10.1155/2015/490531
dc.local.publishedsourcehttp://doi.org/10.1155/2015/490531
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