Now showing items 21-32 of 32

    • miR-379 Regulates Cyclin B1 Expression and Is Decreased in Breast Cancer 

      Khan, Sonja; Brougham, Cathy L.; Ryan, James; Sahrudin, Arisha; O'Neill, Gregory; Wall, Deirdre; Curran, Catherine; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (2013)
      MicroRNAs are small non-coding RNA molecules that control gene expression post-transcriptionally, and are known to be altered in many diseases including breast cancer. The aim of this study was to determine the relevance ...
    • Enlarging neck masses in the elderly - Histological and surgical considerations. 

      O'Sullivan MD, McAnena KS, Egan C, Waters PS, McCann PJ, Kerin MJ (2013)
      INTRODUCTION: Anaplastic carcinoma of the thyroid is a rare but aggressive malignancy which can present with a rapidly enlarging neck mass or compressive sequelae of cough, dyspnoea, dysphagia and hoarseness. Treatment of ...
    • Isolation of secreted microRNAs (miRNAs) from cell-conditioned media 

      Glynn, Claire L.; Khan, Sonja; Kerin, Michael J.; M. Dwyer, Roisin (2013)
      MicroRNAs (miRNAs) have been found to be stable in the circulation of cancer patients raising their potential as circulating biomarkers of disease. The specific source and role, however, of miRNAs in the circulation is ...
    • Clinical applications of gene expression in colorectal cancer. 

      Kerin, Michael J. (2013)
      Despite developments in diagnosis and treatment, 20% of colorectal cancer (CRC) patients present with metastatic disease and 30% of cases recur after curative surgery. Furthermore, the molecular factors involved in prognosis ...
    • Large-scale genotyping identifies 41 new loci associated with breast cancer risk. 

      Kerin, Michael J.; Miller, Nicola (Nature Publishing Group (Macmillan), 2013-03-27)
      Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We ...
    • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. 

      Kerin, Michael J.; Miller, Nicola (Nature Publishing Group (Macmillan), 2013-04)
      TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ~480 SNPs at the TERT locus in breast (n = 103,991), ...
    • Impact of mesenchymal stem cell secreted PAI-1 on colon cancer cell migration and proliferation 

      Hogan, Niamh M.; Joyce, Myles R.; Murphy, J. Mary; Barry, Frank P.; O’Brien, Timothy; Kerin, Michael J.; Dwyer, Róisín M. (Elsevier, 2013-05-16)
      Mesenchymal Stem Cells are known to engraft and integrate into the architecture of colorectal tumours, with little known regarding their fate following engraftment. This study aimed to investigate mediators of Mesenchymal ...
    • Career choices of today's medical students: where does surgery rank? 

      Kerin, Michael J. (Springer, 2013-11-15)
      The national junior doctor recruitment crisis prompts an appraisal of medical student attitudes to different career pathways. The purpose of this study was to perform a national review of surgical career intentions of Irish ...
    • A mixed-methods study of the causes and impact of poor teamwork between junior doctors and nurses 

      O'Connor, Paul; O'Dea, Angela; Lydon, Sinéad; Offiah, Gozie; Scott, Jennifer; Flannery, Antoinette; Lang, Bronagh; Hoban, Anthony; Armstrong, Catherine; Byrne, Dara (Oxford University Press (OUP), 2016-07-02)
      Objectives This study aimed to collect and analyse examples of poor teamwork between junior doctors and nurses; identify the teamwork failures contributing to poor team function; and ascertain if particular teamwork ...
    • Circulating MicroRNAs in cancer 

      O’Brien, Killian P.; Ramphul, Eimear; Howard, Linda; Gallagher, William M.; Malone, Carmel; Kerin, Michael J.; Dwyer, Róisín M. (Humana Press, 2016-11-09)
      It is believed that microRNAs have potential as circulating biomarkers of disease, however successful clinical implementation remains a challenge. This chapter highlights broad variations in approaches to microRNA analysis ...
    • Screening of exosomal microRNAs from colorectal cancer cells 

      Clancy, Cillian; Khan, Sonja; Glynn, Claire L.; Holian, Emma; Dockery, Peter; Lalor, Pierce; Brown, James A.L.; Joyce, Myles R.; Kerin, Michael J.; Dwyer, Róisín M. (IOS Press, 2017-01-03)
      BACKGROUND: Cells release extracellular membrane vesicles including microvesicles known as exosomes. Exosomes contain microRNAs (miRNAs) however the full range within colorectal cancer cell secreted exosomes is unknown.OBJECTIVE: ...
    • Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379 

      O’Brien, K. P.; Khan, S.; Gilligan, K. E.; Zafar, H.; Lalor, P.; Glynn, C.; O’Flatharta, C.; Ingoldsby, H.; Dockery, P.; De Bhulbh, A.; Schweber, J. R.; St John, K.; Leahy, M.; Murphy, J. M.; Gallagher, W. M.; O’Brien, T.; Kerin, Michael J.; Dwyer, Róisín M. (Springer Nature, 2018-01-25)
      Adult Mesenchymal Stem Cells (MSCs) have a well-established tumor-homing capacity, highlighting potential as tumor-targeted delivery vehicles. MSCs secrete extracellular vesicle (EV)-encapsulated microRNAs, which play a ...