Now showing items 3-22 of 31

    • Breast cancer research output, 1945-2008: a bibliometric and density-equalizing analysis 

      Glynn, Ronan W.; Kerin, Michael J. (BioMed Central, 2010-12)
      Introduction: Breast cancer is the most common form of cancer among women, with an estimated 194,280 new cases diagnosed in the United States in 2009 alone. The primary aim of this work was to provide an in-depth evaluation ...
    • Career choices of today's medical students: where does surgery rank? 

      Kerin, Michael J. (Springer, 2013-11-15)
      The national junior doctor recruitment crisis prompts an appraisal of medical student attitudes to different career pathways. The purpose of this study was to perform a national review of surgical career intentions of Irish ...
    • Circulating MicroRNAs in cancer 

      O’Brien, Killian P.; Ramphul, Eimear; Howard, Linda; Gallagher, William M.; Malone, Carmel; Kerin, Michael J.; Dwyer, Róisín M. (Humana Press, 2016-11-09)
      It is believed that microRNAs have potential as circulating biomarkers of disease, however successful clinical implementation remains a challenge. This chapter highlights broad variations in approaches to microRNA analysis ...
    • Clinical applications of gene expression in colorectal cancer. 

      Kerin, Michael J. (2013)
      Despite developments in diagnosis and treatment, 20% of colorectal cancer (CRC) patients present with metastatic disease and 30% of cases recur after curative surgery. Furthermore, the molecular factors involved in prognosis ...
    • Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379 

      O’Brien, K. P.; Khan, S.; Gilligan, K. E.; Zafar, H.; Lalor, P.; Glynn, C.; O’Flatharta, C.; Ingoldsby, H.; Dockery, P.; De Bhulbh, A.; Schweber, J. R.; St John, K.; Leahy, M.; Murphy, J. M.; Gallagher, W. M.; O’Brien, T.; Kerin, Michael J.; Dwyer, Róisín M. (Springer Nature, 2018-01-25)
      Adult Mesenchymal Stem Cells (MSCs) have a well-established tumor-homing capacity, highlighting potential as tumor-targeted delivery vehicles. MSCs secrete extracellular vesicle (EV)-encapsulated microRNAs, which play a ...
    • Endoscopic resection of nasopharyngeal angiofibroma: The role of radio-frequency coblation 

      Ali, Rohana; Keogh, Ivan; Lang, John (PagePress, 2011-08-29)
      Nasopharyngeal angiofibromas are histologically benign but locally aggressive vascular tumors that can result in major morbidity and mortality. They exclusively affect adolescent male and are rare in patients older than ...
    • Enlarging neck masses in the elderly - Histological and surgical considerations. 

      O'Sullivan MD, McAnena KS, Egan C, Waters PS, McCann PJ, Kerin MJ (2013)
      INTRODUCTION: Anaplastic carcinoma of the thyroid is a rare but aggressive malignancy which can present with a rapidly enlarging neck mass or compressive sequelae of cough, dyspnoea, dysphagia and hoarseness. Treatment of ...
    • Impact of mesenchymal stem cell secreted PAI-1 on colon cancer cell migration and proliferation 

      Hogan, Niamh M.; Joyce, Myles R.; Murphy, J. Mary; Barry, Frank P.; O’Brien, Timothy; Kerin, Michael J.; Dwyer, Róisín M. (Elsevier, 2013-05-16)
      Mesenchymal Stem Cells are known to engraft and integrate into the architecture of colorectal tumours, with little known regarding their fate following engraftment. This study aimed to investigate mediators of Mesenchymal ...
    • Incidental findings on MRI scans of patients presenting with audiovestibular symptoms 

      Papanikolaou, Vasileios; Keogh, Ivan J. (Biomed Central, 2010)
      Background:The evaluation of patients presenting with audiovestibular symptoms usually includes MRI of the internal auditory meatus, the cerebellopontine angle and the brain. A significant percentage of these scans will ...
    • Influence of stromal–epithelial interactions on breast cancer in vitro and in vivo 

      Potter, Shirley M.; Dwyer, Róisín M.; Hartmann, Marion C.; Khan, Sonja; Boyle, Marie P.; Curran, Catherine E.; Kerin, Michael J. (Springer, 2011-02-23)
      Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvironment, as mediators of tumor cell migration, proliferation, and angiogenesis. Expression of CCL2 and its principal receptor ...
    • Isolation of secreted microRNAs (miRNAs) from cell-conditioned media 

      Glynn, Claire L.; Khan, Sonja; Kerin, Michael J.; M. Dwyer, Roisin (2013)
      MicroRNAs (miRNAs) have been found to be stable in the circulation of cancer patients raising their potential as circulating biomarkers of disease. The specific source and role, however, of miRNAs in the circulation is ...
    • The KRAS-Variant Is Associated with Risk of Developing Double Primary Breast and Ovarian Cancer 

      Kerin, Michael J.; McVeigh, Terri; Dorairaj, Jemima J.; Heneghan, Helen M.; Miller, Nicola (2012)
      Purpose: A germline microRNA binding site-disrupting variant, the KRAS-variant (rs61764370), is associated with an increased risk of developing several cancers. Because this variant is most strongly associated with ovarian ...
    • Large-scale genotyping identifies 41 new loci associated with breast cancer risk. 

      Kerin, Michael J.; Miller, Nicola (Nature Publishing Group (Macmillan), 2013-03-27)
      Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We ...
    • Mesenchymal stem cell-mediated delivery of the sodium iodide symporter supports radionuclide imaging and treatment of breast cancer 

      Dwyer, Róisín M.; Ryan, James; Havelin, Ronan J.; Morris, John C.; Miller, Brian W.; Liu, Zhonglin; Flavin, Richard; O'Flatharta, Cathal; Foley, Mark J.; Barrett, Harrison H; Murphy, J. Mary; Barry, Frank P; O'Brien, Timothy; Kerin, Michael J. (AlphaMed Press, 2011-05-23)
      Mesenchymal Stem Cells (MSCs) migrate specifically to tumors in vivo, and coupled with their capacity to bypass immune surveillance, are attractive vehicles for tumor-targeted delivery of therapeutic agents. This study ...
    • Mesenchymal Stem Cells (MSCs) and cancer: tumour specific delivery vehicles or therapeutic targets? 

      Dwyer, Róisín M.; Kerin, Michael J. (Mary Ann Liebert, 2010-09-30)
      Mesenchymal stem cells (MSCs) are a subset of nonhematopoietic multipotent cells found primarily within the bone marrow stroma. The ability of MSCs to specifically home to sites of tumors and their metastases, while escaping ...
    • Mesenchymal stem cells in the colorectal tumor microenvironment: Recent progress and implications 

      Hogan, Niamh M.; Dwyer, Róisín M.; Joyce, Myles R.; Kerin, Michael J. (Wiley, 2012-01-30)
      Mesenchymal stem cells (MSCs) are nonhematopoietic multipotent adult stem cells. They have been shown to have a natural tropism for many tumors types, including colorectal, and are capable of escaping host immune surveillance. ...
    • MicroRNA expression in colorectal cancer. 

      Hogan, Niamh M.; Joyce, Myles R. (IOS Press, 2012-12-17)
      Colorectal cancer is a common disease entity with a multi-factorial aetiology which remains poorly understood. It is estimated that in 2008, colorectal cancerwas responsible for 8% of all cancer deaths, making it the fourth ...
    • MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer 

      Chang, Kah Hoong; Mestdagh, Pieter; Vandesompele, Jo; Kerin, Michael J.; Miller, Nicola (Biomed Central, 2010)
      Background Advances in high-throughput technologies and bioinformatics have transformed gene expression profiling methodologies. The results of microarray experiments are often validated using reverse transcription ...
    • miR-379 Regulates Cyclin B1 Expression and Is Decreased in Breast Cancer 

      Khan, Sonja; Brougham, Cathy L.; Ryan, James; Sahrudin, Arisha; O'Neill, Gregory; Wall, Deirdre; Curran, Catherine; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (2013)
      MicroRNAs are small non-coding RNA molecules that control gene expression post-transcriptionally, and are known to be altered in many diseases including breast cancer. The aim of this study was to determine the relevance ...
    • Modern management of pyogenic hepatic abscess: a case series and review of the literature 

      Heneghan, Helen M.; Healy, Nuala A. (BioMed Central, 2011-03)
      Background Pyogenic hepatic abscesses are relatively rare, though untreated are uniformly fatal. A recent paradigm shift in the management of liver abscesses, facilitated by advances in diagnostic and interventional ...