Show simple item record

dc.contributor.authorKazemzadeh, Laleh
dc.contributor.authorCvijovic, Marija
dc.contributor.authorPetranovic, Dina
dc.date.accessioned2018-09-20T16:12:35Z
dc.date.available2018-09-20T16:12:35Z
dc.date.issued2012-01-01
dc.identifier.citationKazemzadeh, Laleh; Cvijovic, Marija; Petranovic, Dina (2012). Boolean model of yeast apoptosis as a tool to study yeast and human apoptotic regulations. Frontiers in Physiology 3 ,
dc.identifier.issn1664-042X
dc.identifier.urihttp://hdl.handle.net/10379/12166
dc.description.abstractProgrammed cell death (PCD) is an essential cellular mechanism that is evolutionary conserved, mediated through various pathways and acts by integrating different stimuli. Many diseases such as neurodegenerative diseases and cancers are found to be caused by, or associated with, regulations in the cell death pathways. Yeast Saccharomyces cerevisiae, is a unicellular eukaryotic organism that shares with human cells components and pathways of the PCD and is therefore used as a model organism. Boolean modeling is becoming promising approach to capture qualitative behavior and describe essential properties of such complex networks. Here we present large literature-based and to our knowledge first Boolean model that combines pathways leading to apoptosis (a type of PCD) in yeast. Analysis of the yeast model confirmed experimental findings of anti-apoptotic role of Bir1 p and pro-apoptotic role of Stm1 p and revealed activation of the stress protein kinase Hog proposing the maximal level of activation upon heat stress. In addition we extended the yeast model and created an in silico humanized yeast in which human pro- and anti-apoptotic regulators BcI-2 family and Valosin-contain protein (VCP) are included in the model.VVe showed that accumulation of Bax in silico humanized yeast shows apoptotic markers and that VCP is essential target of Akt Signaling. The presented Boolean model provides comprehensive description of yeast apoptosis network behavior. Extended model of humanized yeast gives new insights of how complex human disease like neurodegeneration can initially be tested.
dc.publisherFrontiers Media SA
dc.relation.ispartofFrontiers in Physiology
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectapoptosis
dc.subjectboolean modeling
dc.subjectstml
dc.subjectbin
dc.subjecthogl,vcp
dc.subjectbci-2 family
dc.titleBoolean model of yeast apoptosis as a tool to study yeast and human apoptotic regulations
dc.typeArticle
dc.identifier.doi10.3389/fphys.2012.00446
dc.local.publishedsourcehttps://www.frontiersin.org/articles/10.3389/fphys.2012.00446/pdf
nui.item.downloads0


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland