dc.contributor.author | Inrig, Jula K. | |
dc.contributor.author | Patel, Uptal D. | |
dc.contributor.author | Toto, Robert D. | |
dc.contributor.author | Reddan, Donal N. | |
dc.contributor.author | Himmelfarb, Jonathan | |
dc.contributor.author | Lindsay, Robert M. | |
dc.contributor.author | Stivelman, John | |
dc.contributor.author | Winchester, James F. | |
dc.contributor.author | Szczech, Lynda A. | |
dc.date.accessioned | 2018-09-20T16:11:43Z | |
dc.date.available | 2018-09-20T16:11:43Z | |
dc.date.issued | 2009-11-01 | |
dc.identifier.citation | Inrig, Jula K. Patel, Uptal D.; Toto, Robert D.; Reddan, Donal N.; Himmelfarb, Jonathan; Lindsay, Robert M.; Stivelman, John; Winchester, James F.; Szczech, Lynda A. (2009). Decreased pulse pressure during hemodialysis is associated with improved 6-month outcomes. Kidney International 76 (10), 1098-1107 | |
dc.identifier.issn | 0085-2538 | |
dc.identifier.uri | http://hdl.handle.net/10379/12042 | |
dc.description.abstract | Pulse pressure is a well established marker of vascular stiffness and is associated with increased mortality in hemodialysis patients. Here we sought to determine if a decrease in pulse pressure during hemodialysis was associated with improved outcomes using data from 438 hemodialysis patients enrolled in the 6-month Crit-Line Intradialytic Monitoring Benefit Study. The relationship between changes in pulse pressure during dialysis (2-week average) and the primary end point of non-access-related hospitalization and death were adjusted for demographics, comorbidities, medications, and laboratory variables. In the analyses that included both pre- and post-dialysis pulse pressure, higher pre-dialysis and lower post-dialysis pulse pressure were associated with a decreased hazard of the primary end point. Further, every 10 mm Hg decrease in pulse pressure during dialysis was associated with a 20% lower hazard of the primary end point. In separate models that included pulse pressure and the change in pulse pressure during dialysis, neither pre- nor post-dialysis pulse pressure were associated with the primary end point, but each 10 mm Hg decrease in pulse pressure during dialysis was associated with about a 20% lower hazard of the primary end point. Our study found that in prevalent dialysis subjects, a decrease in pulse pressure during dialysis was associated with improved outcomes. Further study is needed to identify how to control pulse pressure to improve outcomes. Kidney International (2009) 76, 1098-1107; doi: 10.1038/ki.2009.340; published online 2 September 2009 | |
dc.publisher | Elsevier BV | |
dc.relation.ispartof | Kidney International | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | end-stage renal disease | |
dc.subject | hemodialysis | |
dc.subject | intradialytic blood pressure | |
dc.subject | morbidity and mortality | |
dc.subject | outcomes | |
dc.subject | pulse pressure | |
dc.subject | left-ventricular hypertrophy | |
dc.subject | stage renal-disease | |
dc.subject | randomized controlled-trial | |
dc.subject | placebo-controlled trial | |
dc.subject | blood-pressure | |
dc.subject | cardiovascular events | |
dc.subject | maintenance hemodialysis | |
dc.subject | dilated cardiomyopathy | |
dc.subject | nocturnal hemodialysis | |
dc.subject | dialysis patients | |
dc.title | Decreased pulse pressure during hemodialysis is associated with improved 6-month outcomes | |
dc.type | Article | |
dc.identifier.doi | 10.1038/ki.2009.340 | |
dc.local.publishedsource | https://doi.org/10.1038/ki.2009.340 | |
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