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dc.contributor.authorGuo, Qi
dc.contributor.authorSchmidt, Marjanka K.
dc.contributor.authorKraft, Peter
dc.contributor.authorCanisius, Sander
dc.contributor.authorChen, Constance
dc.contributor.authorKhan, Sofia
dc.contributor.authorTyrer, Jonathan
dc.contributor.authorBolla, Manjeet K.
dc.contributor.authorWang, Qin
dc.contributor.authorDennis, Joe
dc.contributor.authorMichailidou, Kyriaki
dc.contributor.authorLush, Michael
dc.contributor.authorKar, Siddhartha
dc.contributor.authorBeesley, Jonathan
dc.contributor.authorDunning, Alison M.
dc.contributor.authorShah, Mitul
dc.contributor.authorCzene, Kamila
dc.contributor.authorDarabi, Hatef
dc.contributor.authorEriksson, Mikael
dc.contributor.authorLambrechts, Diether
dc.contributor.authorWeltens, Caroline
dc.contributor.authorLeunen, Karin
dc.contributor.authorBojesen, Stig E.
dc.contributor.authorNordestgaard, Børge G.
dc.contributor.authorNielsen, Sune F.
dc.contributor.authorFlyger, Henrik
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorRudolph, Anja
dc.contributor.authorSeibold, Petra
dc.contributor.authorFlesch-Janys, Dieter
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorFagerholm, Rainer
dc.contributor.authorMuranen, Taru A.
dc.contributor.authorCouch, Fergus J.
dc.contributor.authorOlson, Janet E.
dc.contributor.authorVachon, Celine
dc.contributor.authorAndrulis, Irene L.
dc.contributor.authorKnight, Julia A.
dc.contributor.authorGlendon, Gord
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorBroeks, Annegien
dc.contributor.authorHogervorst, Frans B.
dc.contributor.authorHaiman, Christopher A.
dc.contributor.authorHenderson, Brian E.
dc.contributor.authorSchumacher, Fredrick
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorHopper, John L.
dc.contributor.authorTsimiklis, Helen
dc.contributor.authorApicella, Carmel
dc.contributor.authorSouthey, Melissa C.
dc.contributor.authorCox, Angela
dc.contributor.authorCross, Simon S.
dc.contributor.authorReed, Malcolm W. R.
dc.contributor.authorGiles, Graham G.
dc.contributor.authorMilne, Roger L.
dc.contributor.authorMcLean, Catriona
dc.contributor.authorWinqvist, Robert
dc.contributor.authorPylkäs, Katri
dc.contributor.authorJukkola-Vuorinen, Arja
dc.contributor.authorGrip, Mervi
dc.contributor.authorHooning, Maartje J.
dc.contributor.authorHollestelle, Antoinette
dc.contributor.authorMartens, John W. M.
dc.contributor.authorvan den Ouweland, Ans M. W.
dc.contributor.authorMarme, Federik
dc.contributor.authorSchneeweiss, Andreas
dc.contributor.authorYang, Rongxi
dc.contributor.authorBurwinkel, Barbara
dc.contributor.authorFigueroa, Jonine
dc.contributor.authorChanock, Stephen J.
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorSawyer, Elinor J.
dc.contributor.authorTomlinson, Ian
dc.contributor.authorKerin, Michael J.
dc.contributor.authorMiller, Nicola
dc.contributor.authorBrenner, Hermann
dc.contributor.authorDieffenbach, Aida Karina
dc.contributor.authorArndt, Volker
dc.contributor.authorHolleczek, Bernd
dc.contributor.authorMannermaa, Arto
dc.contributor.authorKataja, Vesa
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorHartikainen, Jaana M.
dc.contributor.authorLi, Jingmei
dc.contributor.authorBrand, Judith S.
dc.contributor.authorHumphreys, Keith
dc.contributor.authorDevilee, Peter
dc.contributor.authorTollenaar, Rob A. E. M.
dc.contributor.authorSeynaeve, Caroline
dc.contributor.authorRadice, Paolo
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorBonanni, Bernardo
dc.contributor.authorMariani, Paolo
dc.contributor.authorFasching, Peter A.
dc.contributor.authorBeckmann, Matthias W.
dc.contributor.authorHein, Alexander
dc.contributor.authorEkici, Arif B.
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorBalleine, Rosemary
dc.contributor.authorPhillips, Kelly-Anne
dc.contributor.authorBenitez, Javier
dc.contributor.authorZamora, M. Pilar
dc.contributor.authorArias Perez, Jose Ignacio
dc.contributor.authorMenéndez, Primitiva
dc.contributor.authorJakubowska, Anna
dc.contributor.authorLubinski, Jan
dc.contributor.authorJaworska-Bieniek, Katarzyna
dc.contributor.authorDurda, Katarzyna
dc.contributor.authorHamann, Ute
dc.contributor.authorKabisch, Maria
dc.contributor.authorUlmer, Hans Ulrich
dc.contributor.authorRüdiger, Thomas
dc.contributor.authorMargolin, Sara
dc.contributor.authorKristensen, Vessela
dc.contributor.authorNord, Silje
dc.contributor.authorEvans, D. Gareth
dc.contributor.authorAbraham, Jean E.
dc.contributor.authorEarl, Helena M.
dc.contributor.authorHiller, Louise
dc.contributor.authorDunn, Janet A.
dc.contributor.authorBowden, Sarah
dc.contributor.authorBerg, Christine
dc.contributor.authorCampa, Daniele
dc.contributor.authorDiver, W. Ryan
dc.contributor.authorGapstur, Susan M.
dc.contributor.authorGaudet, Mia M.
dc.contributor.authorHankinson, Susan E.
dc.contributor.authorHoover, Robert N.
dc.contributor.authorHüsing, Anika
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorMachiela, Mitchell J.
dc.contributor.authorWillett, Walter
dc.contributor.authorBarrdahl, Myrto
dc.contributor.authorCanzian, Federico
dc.contributor.authorChin, Suet-Feung
dc.contributor.authorCaldas, Carlos
dc.contributor.authorHunter, David J.
dc.contributor.authorLindstrom, Sara
dc.contributor.authorGarcía-Closas, Montserrat
dc.contributor.authorHall, Per
dc.contributor.authorEaston, Douglas F.
dc.contributor.authorEccles, Diana M.
dc.contributor.authorRahman, Nazneen
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorPharoah, Paul D. P.
dc.date.accessioned2018-09-20T16:09:55Z
dc.date.available2018-09-20T16:09:55Z
dc.date.issued2015-04-18
dc.identifier.citationGuo, Qi; Schmidt, Marjanka K. Kraft, Peter; Canisius, Sander; Chen, Constance; Khan, Sofia; Tyrer, Jonathan; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Lush, Michael; Kar, Siddhartha; Beesley, Jonathan; Dunning, Alison M.; Shah, Mitul; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Lambrechts, Diether; Weltens, Caroline; Leunen, Karin; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Blomqvist, Carl; Aittomäki, Kristiina; Fagerholm, Rainer; Muranen, Taru A.; Couch, Fergus J.; Olson, Janet E.; Vachon, Celine; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Mulligan, Anna Marie; Broeks, Annegien; Hogervorst, Frans B.; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Hopper, John L.; Tsimiklis, Helen; Apicella, Carmel; Southey, Melissa C.; Cox, Angela; Cross, Simon S.; Reed, Malcolm W. R.; Giles, Graham G.; Milne, Roger L.; McLean, Catriona; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Hooning, Maartje J.; Hollestelle, Antoinette; Martens, John W. M.; van den Ouweland, Ans M. W.; Marme, Federik; Schneeweiss, Andreas; Yang, Rongxi; Burwinkel, Barbara; Figueroa, Jonine; Chanock, Stephen J.; Lissowska, Jolanta; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Holleczek, Bernd; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Li, Jingmei; Brand, Judith S.; Humphreys, Keith; Devilee, Peter; Tollenaar, Rob A. E. M.; Seynaeve, Caroline; Radice, Paolo; Peterlongo, Paolo; Bonanni, Bernardo; Mariani, Paolo; Fasching, Peter A.; Beckmann, Matthias W.; Hein, Alexander; Ekici, Arif B.; Chenevix-Trench, Georgia; Balleine, Rosemary; Phillips, Kelly-Anne; Benitez, Javier; Zamora, M. Pilar; Arias Perez, Jose Ignacio; Menéndez, Primitiva; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Hamann, Ute; Kabisch, Maria; Ulmer, Hans Ulrich; Rüdiger, Thomas; Margolin, Sara; Kristensen, Vessela; Nord, Silje; Evans, D. Gareth; Abraham, Jean E.; Earl, Helena M.; Hiller, Louise; Dunn, Janet A.; Bowden, Sarah; Berg, Christine; Campa, Daniele; Diver, W. Ryan; Gapstur, Susan M.; Gaudet, Mia M.; Hankinson, Susan E.; Hoover, Robert N.; Hüsing, Anika; Kaaks, Rudolf; Machiela, Mitchell J.; Willett, Walter; Barrdahl, Myrto; Canzian, Federico; Chin, Suet-Feung; Caldas, Carlos; Hunter, David J.; Lindstrom, Sara; García-Closas, Montserrat; Hall, Per; Easton, Douglas F.; Eccles, Diana M.; Rahman, Nazneen; Nevanlinna, Heli; Pharoah, Paul D. P. (2015). Identification of novel genetic markers of breast cancer survival. JNCI: Journal of the National Cancer Institute 107 (5),
dc.identifier.issn1460-2105,0027-8874
dc.identifier.urihttp://hdl.handle.net/10379/11766
dc.description.abstractBackground: Survival after a diagnosis of breast cancer varies considerably between patients, and some of this variation may be because of germline genetic variation. We aimed to identify genetic markers associated with breast cancer-specific survival. Methods: We conducted a large meta-analysis of studies in populations of European ancestry, including 37 954 patients with 2900 deaths from breast cancer. Each study had been genotyped for between 200 000 and 900 000 single nucleotide polymorphisms (SNPs) across the genome; genotypes for nine million common variants were imputed using a common reference panel from the 1000 Genomes Project. We also carried out subtype-specific analyses based on 6881 estrogen receptor (ER)-negative patients (920 events) and 23 059 ER-positive patients (1333 events). All statistical tests were two-sided. Results: We identified one new locus (rs2059614 at 11q24.2) associated with survival in ER-negative breast cancer cases (hazard ratio [HR] = 1.95, 95% confidence interval [CI] = 1.55 to 2.47, P = 1.91 x 10(-8)). Genotyping a subset of 2113 case patients, of which 300 were ER negative, provided supporting evidence for the quality of the imputation. The association in this set of case patients was stronger for the observed genotypes than for the imputed genotypes. A second locus (rs148760487 at 2q24.2) was associated at genome-wide statistical significance in initial analyses; the association was similar in ER-positive and ER-negative case patients. Here the results of genotyping suggested that the finding was less robust. Conclusions: This is currently the largest study investigating genetic variation associated with breast cancer survival. Our results have potential clinical implications, as they confirm that germline genotype can provide prognostic information in addition to standard tumor prognostic factors.
dc.publisherOxford University Press (OUP)
dc.relation.ispartofJNCI: Journal of the National Cancer Institute
dc.subjectgenome-wide association
dc.subjectsingle-nucleotide polymorphisms
dc.subjectgenotype imputation
dc.subjectprognosis
dc.subjectrisk
dc.subjectloci
dc.subjectcyclophosphamide
dc.subjectmetaanalysis
dc.subjectprogression
dc.subjectepirubicin
dc.titleIdentification of novel genetic markers of breast cancer survival
dc.typeArticle
dc.identifier.doi10.1093/jnci/djv081
dc.local.publishedsourcehttps://academic.oup.com/jnci/article-pdf/107/5/djv081/17314912/djv081.pdf
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