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dc.contributor.authorGillespie, Paddy
dc.contributor.authorClyne, Barbara
dc.contributor.authorRaymakers, Adam
dc.contributor.authorFahey, Tom
dc.contributor.authorHughes, Carmel M.
dc.contributor.authorSmith, Susan M.
dc.date.accessioned2018-09-20T16:09:11Z
dc.date.available2018-09-20T16:09:11Z
dc.date.issued2017-10-11
dc.identifier.citationGillespie, Paddy; Clyne, Barbara; Raymakers, Adam; Fahey, Tom; Hughes, Carmel M. Smith, Susan M. (2017). Reducing potentially inappropriate prescribing for older people in primary care: cost-effectiveness of the opti-script intervention. International Journal of Technology Assessment in Health Care 33 (4), 494-503
dc.identifier.issn0266-4623,1471-6348
dc.identifier.urihttp://hdl.handle.net/10379/11644
dc.description.abstractObjectives: This study examines the cost-effectiveness of the OPTI-SCRIPT intervention on potentially inappropriate prescribing in primary care. Methods: Economic evaluation, using incremental cost-effectiveness and cost utility analyses, conducted alongside a cluster randomized controlled trial of twenty-one general practices and 196 patients, to compare a multifaceted intervention with usual practice in primary care in Ireland. Potentially inappropriate prescriptions (PIPs) were determined by a pharmacist. Incremental costs, PIPs, and quality-adjusted life-years (QALYs) at 12-month follow-up were estimated using multilevel regression. Uncertainty was explored using cost-effectiveness acceptability curves. Results: The intervention was associated with a nonsignificant mean cost increase of Euro407 (95 percent CIs, -357-1170), a significant mean reduction in PIPs of 0.379 (95 percent CI, 0.092-0.666), and a nonsignificant mean increase in QALYs of 0.013 (95 percent CIs, -0.016-0.042). The incremental cost per PIP avoided was Euro1,269 (95 percent CI, -1400-6302) and the incremental cost per QALY gained was Euro30,535 (95 percent CI, -334,846-289,498). The probability of the intervention being cost-effective was 0.602 at a threshold value of Euro45,000 per QALY gained and was at least 0.845 at threshold values of Euro2,500 per PIP avoided and higher. Conclusions: While the OPTI-SCRIPT intervention was effective in reducing potentially inappropriate prescribing in primary care in Ireland, our findings highlight the uncertainty with respect to its cost-effectiveness. Further studies are required to explore the health and economic implications of interventions targeting potentially inappropriate prescribing.
dc.publisherCambridge University Press (CUP)
dc.relation.ispartofInternational Journal of Technology Assessment in Health Care
dc.subjectcost-effectiveness
dc.subjectrandomized controlled trial
dc.subjectpotentially inappropriate prescribing
dc.subjectprimary care
dc.subjectrandomized controlled-trial
dc.subjectmultifaceted intervention
dc.subjectprospective cohort
dc.subjectoutcomes
dc.titleReducing potentially inappropriate prescribing for older people in primary care: cost-effectiveness of the opti-script intervention
dc.typeArticle
dc.identifier.doi10.1017/s0266462317000782
dc.local.publishedsourcehttps://pure.qub.ac.uk/portal/files/148198769/OPTI_SCRIPT_Manuscript_May_18_.pdf
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