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Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform
(Royal Society of Chemistry, 2018-08-14)
The increasing realization of the involvement of lectin-glycan recognition in (patho)physiological processes inspires envisioning therapeutic intervention by high-avidity/specificity blocking reagents. Synthetic glycoclusters ...
Anomer preferences for glucuronic and galacturonic acid and derivatives and influence of electron-withdrawing substituents
(American Chemical Society, 2018-07-04)
Equilibrium anomeric ratios are reported for pyranoses (hemiacetals) of glucuronic and galacturonic acid and their derivatives. These are compared to related gluco- and galactopyranoses and to deoxyfluorogluco- and ...
Influence of protein (human galectin-3) design on aspects of lectin activity
(Springer, 2020-04-25)
The concept of biomedical significance of the functional pairing between tissue lectins and their glycoconjugate counterreceptors has reached the mainstream of research on the flow of biological information. A major challenge ...
Probing sulfatide-tissue lectin recognition with functionalized glycodendrimersomes
(Cell Press, 2021-01-22)
The small 3-O-sulfated galactose head group of sulfatides, an abundant glycosphingolipid class, poses the (sphinx-like) riddle on involvement of glycan bridging by tissue lectins (sugar code). First, synthesis of head group ...