Browsing School of Chemistry (Scholarly Articles) by Author "Kaltner, Herbert"

Now showing items 1-5 of 5

    • Influence of protein (human galectin-3) design on aspects of lectin activity 

      Caballero, Gabriel Garcia; Beckwith, Donella; Shilova, Nadezhda, V.; Gabba, Adele; Kutzner, Tanja J.; Ludwig, Anna-Kristin; Manning, Joachim C.; Kaltner, Herbert; Sinowatz, Fred; Cudic, Mare; Bovin, Nicolai, V.; Murphy, Paul V.; Gabius, Hans-Joachim (Springer, 2020-04-25)
      The concept of biomedical significance of the functional pairing between tissue lectins and their glycoconjugate counterreceptors has reached the mainstream of research on the flow of biological information. A major challenge ...

    • Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context 

      André, Sabine; Kaltner, Herbert; Kayser, Klaus; Murphy, Paul V.; Gabius, Hans-Joachim (Springer, 2015-11-09)
      Recognition of glycans by lectins leads to cell adhesion and growth regulation. The specificity and selectivity of this process are determined by carbohydrate structure (sequence and shape) and topology of its presentation. ...

    • Probing sulfatide-tissue lectin recognition with functionalized glycodendrimersomes 

      Murphy, Paul V.; Romero, Antonio; Xiao, Qi; Ludwig, Anna-Kristin; Jogula, Srinivas; Shilova, Nadezhda V.; Singh, Tanuja; Gabba, Adele; Javed, Bilal; Zhang, Dapeng; Medrano, Francisco J.; Kaltner, Herbert; Kopitz, Jürgen; Bovin, Nicolai V.; Wu, Albert M.; Klein, Michael L.; Percec, Virgil; Gabius, Hans-Joachim (Cell Press, 2021-01-22)
      The small 3-O-sulfated galactose head group of sulfatides, an abundant glycosphingolipid class, poses the (sphinx-like) riddle on involvement of glycan bridging by tissue lectins (sugar code). First, synthesis of head group ...

    • Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform 

      Kaltner, Herbert; Manning, Joachim C.; García Caballero, Gabriel; Di Salvo, Claudia; Gabba, Adele; Romero-Hernández, Laura L.; Knospe, Clemens; Wu, Dan; Daly, Harrison C.; O'Shea, Donal F.; Gabius, Hans-Joachim; Murphy, Paul V. (Royal Society of Chemistry, 2018-08-14)
      The increasing realization of the involvement of lectin-glycan recognition in (patho)physiological processes inspires envisioning therapeutic intervention by high-avidity/specificity blocking reagents. Synthetic glycoclusters ...

    • Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design 

      Roy, René; Cao, Yihong; Kaltner, Herbert; Kottari, Naresh; Shiao, Tze Chieh; Belkhadem, Karima; André, Sabine; Manning, Joachim C.; Murphy, Paul V.; Gabius, Hans-Joachim (Springer, 2016-06-24)
      A hallmark of endogenous lectins is their ability to select a few distinct glycoconjugates as counterreceptors for functional pairing from the natural abundance of cellular glycoproteins and glycolipids. As a consequence, ...