Browsing School of Chemistry (Scholarly Articles) by Title
Now showing items 229-248 of 347
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Multi-attribute quality screening of immunoglobulin G using polarized Excitation Emission Matrix spectroscopy
(Elsevier, 2019-12-10)Immunoglobulin G (IgG) is often used as a starting material for the production of functionalised antibodies, like Antibody Drug Conjugates (ADCs), PEGlyated-conjugates, or radioimmunoconjugates. The gross structural quality ... -
Multiplexed electrochemical cancer diagnostics with automated microfluidics
(Wiley, 2018-11-27)Microfluidic platforms can lead to miniaturisation, increased throughput and reduced reagent consumption, particularly when the processes are automated. Here, a programmable microcontroller is used for automation of a ... -
Multivalent carbohydrate-lectin interactions: the way synthetic chemistry enables insights into nanometric recognition
(MDPI Open Access, 2016-05-13)Glycan recognition by sugar receptors (lectins) is intimately involved in many aspects of cell physiology. However, the factors explaining the exquisite selectivity of their functional pairing are not yet fully understood. ... -
N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines
(Elsevier, 2018-12-04)1,5-Dideoxy-1,5-imino-l-fucitol (1-deoxyfuconojirimycin, DFJ) is an iminosugar that inhibits fucosidases. Herein, N-alkyl DFJs have been synthesised and tested against the ¿-fucosidases of T. maritima (bacterial origin) ... -
The natural bile acid surfactant sodium taurocholate (NaTC) as a coformer in coamorphous systems: Enhanced physical stability and dissolution behavior of coamorphous drug-NaTc systems
(Elsevier, 2018-10-28)The amorphization of 18 different drugs on milling with one mole equivalent sodium taurocholate (NaTC) was investigated. In all cases the X-ray powder pattern showed an amorphous halo after milling at room temperature or ... -
A new era for homolytic aromatic substitution: replacing Bu3SnH with efficient light-induced chain reactions
(Royal Society of Chemistry, 2016-04-01)Herein is a pertinent review of recent photochemical homolytic aromatic substitution (HAS) literature. Issues with using the reductant Bu3SnH in an oxidative process where the net loss of a hydrogen atom occurs is discussed. ... -
New experimental insights into acetylene oxidation through novel ignition delay times, laminar burning velocities and chemical kinetic modelling
(Elsevier, 2018-08-03)The oxidation of acetylene is central to the oxidation of virtually all hydrocarbon fuels. It is also important for commercial industry, due to its wide range of applications such as flame photometry, atomic absorption, ... -
Numerical study on the minimum ignition energy of a methane-air mixture
(Elsevier, 2020-09-28)In this paper, a semi-detailed mechanism is used to calculate the minimum ignition energy (MIE) of methane-air mixtures, with all calculations conducted using ANSYS Fluent software. Ignition behaviors between success and ... -
Old dog, new tricks: 2,2'-biphenol as a bridging and book-end ligand in discrete and extended Co(II) architectures
(RSC, 2012-02-01)We report the first Co(ii) based discrete and extended network materials comprising the 2,2[prime or minute]-biphenol ligand. We first present the synthesis and magnetic characterisation of the Co(ii) dinuclear complexes ... -
On the use of 31P NMR for the quantification of hydrosoluble phosphorus-containing compounds in coral host tissues and cultured zooxanthellae
(Nature Publishing Group, 2016-02-23)31P Nuclear Magnetic Resonance (NMR) was assessed to investigate the phosphorus-containing compounds present in the tissues of the scleractinian coral Stylophora pistillata as well as of cultured zooxanthellae (CZ). Results ... -
One-pot hydrogen peroxide and hydrohalic acid induced ring closure and selective aromatic halogenation to give new ring-fused benzimidazoles
(American Chemical Society, 2015-05-19)A new series of selectively dichlorinated and dibrominated five- to eight-membered-ring [1,2-a]-fused benzimidazoles and [1,4]oxazino[4,3-a]benzimidazoles are synthesized in mostly high yields of >80% using the reaction ... -
Optimization of a hydrogen combustion mechanism using both direct and indirect measurements
(Elsevier ScienceDirect, 2014-07-05)The Keromnes et al. (2013) mechanism for hydrogen combustion has been optimized using a large set of indirect experimental data, consisting of ignition measurements in shock tubes (566 datapoints in 43 datasets) and rapid ... -
Optimized reaction mechanism rate rules for ignition of normal alkanes
(Elsevier, 2016-08-10)The increasing demand for cleaner combustion and reduced greenhouse gas emissions motivates research on the combustion of hydrocarbon fuels and their surrogates. Accurate detailed chemical kinetic models are an important ... -
The oxidation of 2-butene: A high pressure ignition delay, kinetic modeling study and reactivity comparison with isobutene and 1-butene
(Elsevier, 2016-06-16)Butenes are intermediates ubiquitously formed by decomposition and oxidation of larger hydrocarbons (e.g. alkanes) or alcohols present in conventional or reformulated fuels. In this study, a series of novel igni-tion delay ... -
Oxidation of ethylene-air mixtures at elevated pressures, part 1: experimental results
(American Institute of Aeronautics and Astronautics, 2014-03-26)Shock-tube experiments have been performed to determine ignition delay times of undiluted ethylene air mixtures for temperatures from 1003 to 1401 K, at equivalence ratios from 0.3 to 2.0, and at pressures from 1.1 to 24.9 ... -
Oxidation of ethylene-air mixtures at elevated pressures, part 2: chemical kinetics
(American Institute of Aeronautics and Astronautics, 2014-03-27)A chemical kinetics submechanism for small molecular weight hydrocarbons was modified by adjusting rate constants to produce better agreement with recent ethylene ignition delay time data compared with an earlier version ... -
Oxidative stress induced by Pt(IV) pro-drugs based on the cisplatin scaffold and indole carboxylic acids in axial position
(Nature Publishing Group, 2016-06-11)The use of Pt(IV) complexes as pro-drugs that are activated by intracellular reduction is a widely investigated approach to overcome the limitations of Pt(II) anticancer agents. A series of ten mono- and bis-carboxylated ... -
Performance Monitoring of a Mammalian Cell Based Bioprocess using Raman spectroscopy.
(2013)Being able to predict the final product yield at all stages in long-running, industrial, mammalian cell culture processes is vital for both operational efficiency, process consistency, and the implementation of Quality by ... -
Phosphate diester cleavage, DNA interaction and cytotoxic Activity of a bimetallic bis(1,4,7-triazacyclononane) zinc complex
(Wiley, 2014-06-24)The dinuclear zinc complex [Zn-2{bcmp(-H)}(mu-Cl)](ClO4)(2)center dot H2O {bcmp = 2,6-bis(1,4,7-triazacyclonon-1-ylmethyl)-4-methylphenol} has been synthesized and structurally characterized. The DNA binding affinity was ... -
A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage
(Oxford University Press, 2018-09-17)Free radical generation is an inevitable consequence of aerobic existence and is implicated in a wide variety of pathological conditions including cancer, cardiovascular disease, ageing and neurodegenerative disorder. Free ...