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dc.contributor.authorFeehily, C.
dc.contributor.authorKaratzas, K.A.G.
dc.identifier.citationFeehily, C. Karatzas, K.A.G. (2012). Role of glutamate metabolism in bacterial responses towards acid and other stresses. Journal of Applied Microbiology 114 (1), 11-24
dc.description.abstractGlutamate plays a central role in a wide range of metabolic processes in bacterial cells. This review focuses on the involvement of glutamate in bacterial stress responses. In particular, it reviews the role of glutamate metabolism in response against acid stress and other stresses. The glutamate decarboxylase (GAD) system has been implicated in acid tolerance in several bacterial genera. This system facilitates intracellular pH homoeostasis by consuming protons in a decarboxylation reaction that produces ?-aminobutyrate (GABA) from glutamate. An antiporter system is usually present to couple the uptake of glutamate to the efflux of GABA. Recent insights into the functioning of this system will be discussed. Finally, the intracellular fate of GABA will also be discussed. Many bacteria are capable of metabolizing GABA to succinate via the GABA shunt pathway. The role and regulation of this pathway will be addressed in the review.
dc.relation.ispartofJournal of Applied Microbiology
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectacid resistance
dc.subjectglutamate decarboxylase
dc.subjectglutamate metabolism
dc.subjectlisteria monocytogenes
dc.subjectescherichia-coli k-12
dc.subjectsuccinic semialdehyde dehydrogenase
dc.subjectlisteria-monocytogenes strains
dc.subjectsemi-aldehyde dehydrogenases
dc.subjectcomplete genome sequence
dc.subjectdependent acid
dc.subjectdecarboxylase system
dc.titleRole of glutamate metabolism in bacterial responses towards acid and other stresses

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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland