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dc.contributor.authorEgan, Aoife M.
dc.contributor.author,
dc.contributor.authorVellinga, Akke
dc.contributor.authorHarreiter, Jürgen
dc.contributor.authorSimmons, David
dc.contributor.authorDesoye, Gernot
dc.contributor.authorCorcoy, Rosa
dc.contributor.authorAdelantado, Juan M.
dc.contributor.authorDevlieger, Roland
dc.contributor.authorVan Assche, Andre
dc.contributor.authorGaljaard, Sander
dc.contributor.authorDamm, Peter
dc.contributor.authorMathiesen, Elisabeth R.
dc.contributor.authorJensen, Dorte M.
dc.contributor.authorAndersen, Liselotte
dc.contributor.authorLapolla, Annuziata
dc.contributor.authorDalfrà, Maria G.
dc.contributor.authorBertolotto, Alessandra
dc.contributor.authorMantaj, Urszula
dc.contributor.authorWender-Ozegowska, Ewa
dc.contributor.authorZawiejska, Agnieszka
dc.contributor.authorHill, David
dc.contributor.authorJelsma, Judith G. M.
dc.contributor.authorSnoek, Frank J.
dc.contributor.authorWorda, Christof
dc.contributor.authorBancher-Todesca, Dagmar
dc.contributor.authorvan Poppel, Mireille N. M.
dc.contributor.authorKautzky-Willer, Alexandra
dc.contributor.authorDunne, Fidelma P.
dc.date.accessioned2018-09-20T16:07:03Z
dc.date.available2018-09-20T16:07:03Z
dc.date.issued2017-07-12
dc.identifier.citationEgan, Aoife M. , ; Vellinga, Akke; Harreiter, Jürgen; Simmons, David; Desoye, Gernot; Corcoy, Rosa; Adelantado, Juan M.; Devlieger, Roland; Van Assche, Andre; Galjaard, Sander; Damm, Peter; Mathiesen, Elisabeth R.; Jensen, Dorte M.; Andersen, Liselotte; Lapolla, Annuziata; Dalfrà, Maria G.; Bertolotto, Alessandra; Mantaj, Urszula; Wender-Ozegowska, Ewa; Zawiejska, Agnieszka; Hill, David; Jelsma, Judith G. M.; Snoek, Frank J.; Worda, Christof; Bancher-Todesca, Dagmar; van Poppel, Mireille N. M.; Kautzky-Willer, Alexandra; Dunne, Fidelma P. (2017). Epidemiology of gestational diabetes mellitus according to iadpsg/who 2013 criteria among obese pregnant women in europe. Diabetologia 60 (10), 1913-1921
dc.identifier.issn0012-186X,1432-0428
dc.identifier.urihttp://hdl.handle.net/10379/11326
dc.description.abstractAims/hypothesis Accurate prevalence estimates for gestational diabetes mellitus (GDM) among pregnant women in Europe are lacking owing to the use of a multitude of diagnostic criteria and screening strategies in both high-risk women and the general pregnant population. Our aims were to report important risk factors for GDM development and calculate the prevalence of GDMin a cohort of women withBMI >= 29 kg/m(2) across 11 centres in Europe using the International Association of the Diabetes and Pregnancy Study Groups (IADPSG)/WHO 2013 diagnostic criteria. Methods Pregnant women (n = 1023, 86.3% European ethnicity) with a BMI = 29.0 kg/m(2) enrolled into the Vitamin D and Lifestyle Intervention for GDM Prevention (DALI) pilot, lifestyle and vitamin D studies of this pan-European multicentre trial, attended for an OGTT during pregnancy. Demographic, anthropometric and metabolic data were collected at enrolment and throughout pregnancy. GDM was diagnosed using IADPSG/WHO 2013 criteria. GDM treatment followed local policies. Results The number of women recruited per country ranged from 80 to 217, and the dropout rate was 7.1%. Overall, 39% of women developed GDM during pregnancy, with no significant differences in prevalence across countries. The prevalence of GDM was high (24%; 242/1023) in early pregnancy. Despite interventions used in the DALI study, a further 14% (94/672) had developed GDM when tested at mid gestation (24-28 weeks) and 13% (59/476) of the remaining cohort at late gestation (35-37 weeks). Demographics and lifestyle factors were similar at baseline between women with GDM and those who maintained normal glucose tolerance. Previous GDM (16.5% vs 7.9%, p = 0.002), congenital malformations (6.4% vs 3.3%, p = 0.045) and a baby with macrosomia (31.4% vs 17.9%, p = 0.001) were reported more frequently in those who developed GDM. Significant anthropometric and metabolic differences were already present in early pregnancy between women who developed GDM and those who did not. Conclusions/interpretation The prevalence of GDM diagnosed by the IADPSG/WHO 2013 GDM criteria in European pregnant women with a BMI >= 29.0 kg/m(2) is substantial, and poses a significant health burden to these pregnancies and to the future health of the mother and her offspring. Uniform criteria for GDM diagnosis, supported by robust evidence for the benefits of treatment, are urgently needed to guide modern GDM screening and treatment strategies.
dc.publisherSpringer Nature
dc.relation.ispartofDiabetologia
dc.subjectclinical diabetes
dc.subjectclinical science and care
dc.subjectepidemiology
dc.subjecthealthcare delivery
dc.subjectpregnancy
dc.subjectweight regulation and obesity
dc.subjectdali life-style
dc.subjectinternational association
dc.subjectinsulin sensitivity
dc.subjectglucose-tolerance
dc.subjecthyperglycemia
dc.subjectdiagnosis
dc.subjectclassification
dc.subjectcircumference
dc.subjectmulticenter
dc.subjectgynecology
dc.titleEpidemiology of gestational diabetes mellitus according to iadpsg/who 2013 criteria among obese pregnant women in europe
dc.typeArticle
dc.identifier.doi10.1007/s00125-017-4353-9
dc.local.publishedsourcehttps://link.springer.com/content/pdf/10.1007%2Fs00125-017-4353-9.pdf
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