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dc.contributor.authorDoyle, Karen M.
dc.contributor.authorKennedy, Donna
dc.contributor.authorGorman, Adrienne M.
dc.contributor.authorGupta, Sanjeev
dc.contributor.authorHealy, Sandra J. M.
dc.contributor.authorSamali, Afshin
dc.date.accessioned2018-09-20T16:06:30Z
dc.date.available2018-09-20T16:06:30Z
dc.date.issued2011-09-26
dc.identifier.citationDoyle, Karen M. Kennedy, Donna; Gorman, Adrienne M.; Gupta, Sanjeev; Healy, Sandra J. M.; Samali, Afshin (2011). Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. Journal of Cellular and Molecular Medicine 15 (10), 2025-2039
dc.identifier.issn1582-1838
dc.identifier.urihttp://hdl.handle.net/10379/11250
dc.description.abstractThe stimuli for neuronal cell death in neurodegenerative disorders are multi-factorial and may include genetic predisposition, environmental factors, cellular stressors such as oxidative stress and free radical production, bioenergy failure, glutamate-induced excitotoxicity, neuroinflammation, disruption of Ca2+-regulating systems, mitochondrial dysfunction and misfolded protein accumulation. Cellular stress disrupts functioning of the endoplasmic reticulum (ER), a critical organelle for protein quality control, leading to induction of the unfolded protein response (UPR). ER stress may contribute to neurodegeneration in a range of neurodegenerative disorders. This review summarizes the molecular events occurring during ER stress and the unfolded protein response and it specifically evaluates the evidence suggesting the ER stress response plays a role in neurodegenerative disorders.
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Cellular and Molecular Medicine
dc.subjectneurodegeneration
dc.subjecter stress
dc.subjectupr
dc.subjectapoptosis
dc.subjectautophagy
dc.subjectalzheimer's disease
dc.subjectparkinson's disease
dc.subjectamyotrophic lateral sclerosis
dc.subjectprions disease
dc.subjectamyotrophic-lateral-sclerosis
dc.subjectubiquitin-proteasome system
dc.subjectmotor-neuron disease
dc.subjectinduced cell-death
dc.subjectalzheimers-disease
dc.subjecter stress
dc.subjectparkinsons-disease
dc.subjectprion protein
dc.subjectoxidative stress
dc.subjectalpha-synuclein
dc.titleUnfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders
dc.typeArticle
dc.identifier.doi10.1111/j.1582-4934.2011.01374.x
dc.local.publishedsourcehttp://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2011.01374.x/pdf
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