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dc.contributor.authorDelgado, Luis M.
dc.contributor.authorBayon, Yves
dc.contributor.authorPandit, Abhay
dc.contributor.authorZeugolis, Dimitrios I.
dc.identifier.citationDelgado, Luis M. Bayon, Yves; Pandit, Abhay; Zeugolis, Dimitrios I. (2015). To cross-link or not to cross-link? cross-linking associated foreign body response of collagen-based devices. Tissue Engineering Part B: Reviews 21 (3), 298-313
dc.description.abstractCollagen-based devices, in various physical conformations, are extensively used for tissue engineering and regenerative medicine applications. Given that the natural cross-linking pathway of collagen does not occur in vitro, chemical, physical, and biological cross-linking methods have been assessed over the years to control mechanical stability, degradation rate, and immunogenicity of the device upon implantation. Although in vitro data demonstrate that mechanical properties and degradation rate can be accurately controlled as a function of the cross-linking method utilized, preclinical and clinical data indicate that cross-linking methods employed may have adverse effects on host response, especially when potent cross-linking methods are employed. Experimental data suggest that more suitable cross-linking methods should be developed to achieve a balance between stability and functional remodeling.
dc.publisherMary Ann Liebert Inc
dc.relation.ispartofTissue Engineering Part B: Reviews
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectdermal sheep collagen
dc.subjecttissue engineering scaffolds
dc.subjectguided bone regeneration
dc.subjectabdominal-wall defect
dc.subjectventral hernia repair
dc.subjectrotator cuff tears
dc.subjectin-vivo evaluation
dc.subjectmacrophage phenotype
dc.titleTo cross-link or not to cross-link? cross-linking associated foreign body response of collagen-based devices

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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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