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dc.contributor.authorDeegan, B. M.
dc.contributor.authorDevine, E. R.
dc.contributor.authorGeraghty, M. C.
dc.contributor.authorJones, E.
dc.contributor.authorOLaighin, G.
dc.contributor.authorSerrador, J. M.
dc.date.accessioned2018-09-20T16:05:33Z
dc.date.available2018-09-20T16:05:33Z
dc.date.issued2010-08-05
dc.identifier.citationDeegan, B. M. Devine, E. R.; Geraghty, M. C.; Jones, E.; OLaighin, G.; Serrador, J. M. (2010). The relationship between cardiac output and dynamic cerebral autoregulation in humans. Journal of Applied Physiology 109 (5), 1424-1431
dc.identifier.issn8750-7587,1522-1601
dc.identifier.urihttp://hdl.handle.net/10379/11118
dc.description.abstractCerebral autoregulation adjusts cerebrovascular resistance in the face of changing perfusion pressures to maintain relatively constant flow. Results from several studies suggest that cardiac output may also play a role. We tested the hypothesis that cerebral blood flow would autoregulate independent of changes in cardiac output. Transient systemic hypotension was induced by thigh-cuff deflation in 19 healthy volunteers (7 women) in both supine and seated positions. Mean arterial pressure (Finapres), cerebral blood flow (transcranial Doppler) in the anterior (ACA) and middle cerebral artery (MCA), beat-by-beat cardiac output (echocardiography), and end-tidal PCO(2) were measured. Autoregulation was assessed using the autoregulatory index (ARI) defined by Tiecks et al. (Tiecks FP, Lam AM, Aaslid R, Newell DW. Stroke 26: 1014-1019, 1995). Cerebral autoregulation was better in the supine position in both the ACA [supine ARI: 5.0 +/- 0.21 (mean +/- SE), seated ARI: 3.9 +/- 0.4, P = 0.01] and MCA (supine ARI: 5.0 +/- 0.2, seated ARI: 3.8 +/- 0.3, P = 0.004). In contrast, cardiac output responses were not different between positions and did not correlate with cerebral blood flow ARIs. In addition, women had better autoregulation in the ACA (P = 0.046), but not the MCA, despite having the same cardiac output response. These data demonstrate cardiac output does not appear to affect the dynamic cerebral autoregulatory response to sudden hypotension in healthy controls, regardless of posture. These results also highlight the importance of considering sex when studying cerebral autoregulation.
dc.publisherAmerican Physiological Society
dc.relation.ispartofJournal of Applied Physiology
dc.subjectcerebral blood flow
dc.subjectechocardiography
dc.subjecttranscranial doppler
dc.subjectartery blood velocity
dc.subjectleft-ventricular volumes
dc.subjectflow velocity
dc.subjectgender-differences
dc.subjectorthostatic stress
dc.subjectauto-regulation
dc.subjectexercise
dc.subjectpressure
dc.subjectperfusion
dc.subjectechocardiography
dc.titleThe relationship between cardiac output and dynamic cerebral autoregulation in humans
dc.typeArticle
dc.identifier.doi10.1152/japplphysiol.01262.2009
dc.local.publishedsourcehttp://jap.physiology.org/content/jap/109/5/1424.full.pdf
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