Show simple item record

dc.contributor.authorDaly, Eileen
dc.contributor.authorEcker, Christine
dc.contributor.authorHallahan, Brian
dc.contributor.authorDeeley, Quinton
dc.contributor.authorCraig, Michael
dc.contributor.authorMurphy, Clodagh
dc.contributor.authorJohnston, Patrick
dc.contributor.authorSpain, Debbie
dc.contributor.authorGillan, Nicola
dc.contributor.authorGudbrandsen, Maria
dc.contributor.authorBrammer, Michael
dc.contributor.authorGiampietro, Vincent
dc.contributor.authorLamar, Melissa
dc.contributor.authorPage, Lisa
dc.contributor.authorToal, Fiona
dc.contributor.authorSchmitz, Nicole
dc.contributor.authorCleare, Anthony
dc.contributor.authorRobertson, Dene
dc.contributor.authorRubia, Katya
dc.contributor.authorMurphy, Declan G. M.
dc.date.accessioned2018-09-20T16:04:54Z
dc.date.available2018-09-20T16:04:54Z
dc.date.issued2014-07-27
dc.identifier.citationDaly, Eileen; Ecker, Christine; Hallahan, Brian; Deeley, Quinton; Craig, Michael; Murphy, Clodagh; Johnston, Patrick; Spain, Debbie; Gillan, Nicola; Gudbrandsen, Maria; Brammer, Michael; Giampietro, Vincent; Lamar, Melissa; Page, Lisa; Toal, Fiona; Schmitz, Nicole; Cleare, Anthony; Robertson, Dene; Rubia, Katya; Murphy, Declan G. M. (2014). Response inhibition and serotonin in autism: a functional mri study using acute tryptophan depletion. Brain 137 , 2600-2610
dc.identifier.issn1460-2156,0006-8950
dc.identifier.urihttp://hdl.handle.net/10379/11029
dc.description.abstractIt has been suggested that the restricted, stereotyped and repetitive behaviours typically found in autism are underpinned by deficits of inhibitory control. The biological basis of this is unknown but may include differences in the modulatory role of neurotransmitters, such as serotonin, which are implicated in the condition. However, this has never been tested directly. We therefore assessed the modifying role of serotonin on inhibitory brain function during a Go/No-Go task in 14 adults with autism and normal intelligence and 14 control subjects that did not differ in gender, age and intelligence. We undertook a double-blind, placebo-controlled, crossover trial of acute tryptophan depletion using functional magnetic resonance imaging. Following sham, adults with autism relative to controls had reduced activation in key inhibitory regions of inferior frontal cortex and thalamus, but increased activation of caudate and cerebellum. However, brain activation was modulated in opposite ways by depletion in each group. Within autistic individuals depletion upregulated fronto-thalamic activations and downregulated striato-cerebellar activations toward control sham levels, completely 'normalizing' the fronto-cerebellar dysfunctions. The opposite pattern occurred in controls. Moreover, the severity of autism was related to the degree of differential modulation by depletion within frontal, striatal and thalamic regions. Our findings demonstrate that individuals with autism have abnormal inhibitory networks, and that serotonin has a differential, opposite, effect on them in adults with and without autism. Together these factors may partially explain the severity of autistic behaviours and/or provide a novel (tractable) treatment target.
dc.publisherOxford University Press (OUP)
dc.relation.ispartofBrain
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectautistic spectrum disorder
dc.subjectimpulsivity and inhibition disorders
dc.subjectevent-related fmri
dc.subjectspectrum disorders
dc.subjectbehavioral-inhibition
dc.subjectrepetitive behaviors
dc.subjectneuronal responses
dc.subjecthealthy-volunteers
dc.subjectaspergers-syndrome
dc.subjectstop-signal
dc.subjecthuman-brain
dc.subjecthumans
dc.titleResponse inhibition and serotonin in autism: a functional mri study using acute tryptophan depletion
dc.typeArticle
dc.identifier.doi10.1093/brain/awu178
dc.local.publishedsourcehttps://academic.oup.com/brain/article-pdf/137/9/2600/13798228/awu178.pdf
nui.item.downloads0


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland