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dc.contributor.authorCostiniuk, Cecilia T.
dc.contributor.authorMehraj, Vikram
dc.contributor.authorRouty, Jean-Pierre
dc.contributor.authorde Castro, Christina
dc.contributor.authorWasef, Natale
dc.contributor.authorJenabian, Mohammad-Ali
dc.contributor.authorSalahuddin, Syim
dc.contributor.authorLebouché, Bertrand
dc.contributor.authorCox, Joseph
dc.contributor.authorSzabo, Jason
dc.contributor.authorKlein, Marina
dc.contributor.authorLands, Larry
dc.contributor.authorShapiro, Adam J.
dc.identifier.citationCostiniuk, Cecilia T. Mehraj, Vikram; Routy, Jean-Pierre; de Castro, Christina; Wasef, Natale; Jenabian, Mohammad-Ali; Salahuddin, Syim; Lebouché, Bertrand; Cox, Joseph; Szabo, Jason; Klein, Marina; Lands, Larry; Shapiro, Adam J. (2018). Nasal nitric oxide levels in hiv infection: a cross-sectional study. AIDS Research and Treatment ,
dc.description.abstractIntroduction. Low levels of nasal NO have been associated with increased propensity to rhinosinusitis and respiratory tract infections. Our objective was to describe nasalNOlevels in HIV-infected individuals versus healthy controls and determine possible risk factors for reduced nasal NO levels. Materials and Methods. HIV-infected individuals and healthy controls were recruited. Participants underwent nasal NO testing by standardized methods using a CLD88 chemiluminescence analyzer and completed the Sinonasal Outcome Test-20 (SNOT-20) on symptoms of rhinosinusitis. Results. Participants included 41 HIV-infected individuals with suppressed VL on antiretroviral therapy (ART group), 5HIV-infected individuals with detectable VL off ART (viremic group), and 12 healthy controls (HC group). Mean nasal NO level was 253 (+/- 77) nL/min in the ART group, 213 (+/- 48) nL/min in the viremic group, and 289 (+/- 68) nL/min in the HC group (p = 0.133; ANOVA). There was no correlation between nasal NO level and VL in viremic individuals (p = -0.200;p = 0.747). Differences were observed in mean total points on the SNOT-20 which were 19 (+/- 16)/100, 18 (+/- 26)/100, and 4 (+/- 4)/100 in the ART, viremic, and HC groups, respectively (p = 0.013; ANOVA). Conclusion. Healthy individuals, HIV patients on ART, and viremic individuals off ART display similar nasalNOlevels. However, rhinosinusitis symptoms remain prominent despite ART-treatment.
dc.publisherHindawi Limited
dc.relation.ispartofAIDS Research and Treatment
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectantiretroviral therapy
dc.subjectchronic rhinosinusitis
dc.subjectsinus surgery
dc.titleNasal nitric oxide levels in hiv infection: a cross-sectional study

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