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dc.contributor.authorConway, C.
dc.contributor.authorMcGarry, J. P.
dc.contributor.authorEdelman, E. R.
dc.contributor.authorMcHugh, P. E.
dc.date.accessioned2018-09-20T16:03:58Z
dc.date.available2018-09-20T16:03:58Z
dc.date.issued2017-05-09
dc.identifier.citationConway, C. McGarry, J. P.; Edelman, E. R.; McHugh, P. E. (2017). Numerical simulation of stent angioplasty with predilation: an investigation into lesion constitutive representation and calcification influence. Annals of Biomedical Engineering 45 (9), 2244-2252
dc.identifier.issn0090-6964,1573-9686
dc.identifier.urihttp://hdl.handle.net/10379/10888
dc.description.abstractIt is acceptable clinical practice to predilate a severely occluded vessel to allow better positioning of endovascular stents, and while the impact of this intervention has been examined for aggregate response in animals there has been no means to examine whether there are specific vessels that might benefit. Finite element methods offer the singular ability to explore the mechanical response of arteries with specific pathologic alterations in mechanics to stenting and predilation. We examined varying representations of atherosclerotic tissue including homogeneous and heterogeneous dispersion of calcified particles, and elastic, pseudo-elastic, and elastic-plastic constitutive representations of bulk atherosclerotic tissue. The constitutive representations of the bulk atherosclerotic tissue were derived from experimental test data and highlight the importance of accounting for testing mode of loading. The impact of arterial predilation is presented and, in particular, its effect on intimal predicted damage, atherosclerotic tissue von Mises and maximum principal stresses, and luminal deformation was dependent on the type of constitutive representation of diseased tissue, particularly in the presence of calcifications.
dc.publisherSpringer Nature
dc.relation.ispartofAnnals of Biomedical Engineering
dc.subjectstent
dc.subjectatherosclerosis
dc.subjectpredilation angioplasty
dc.subjectfinite element analysis
dc.subjectpseudo-elasticity
dc.subjectcalcification
dc.subjectatherosclerotic plaques
dc.subjectbiological-materials
dc.subjecttissue
dc.subjectarteries
dc.subjectmodel
dc.titleNumerical simulation of stent angioplasty with predilation: an investigation into lesion constitutive representation and calcification influence
dc.typeArticle
dc.identifier.doi10.1007/s10439-017-1851-3
dc.local.publishedsourcehttp://europepmc.org/articles/pmc5963267?pdf=render
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