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dc.contributor.authorChianese, Giuseppina
dc.contributor.authorScala, Fernando
dc.contributor.authorCalcinai, Barbara
dc.contributor.authorCerrano, Carlo
dc.contributor.authorDien, Henny
dc.contributor.authorKaiser, Marcel
dc.contributor.authorTasdemir, Deniz
dc.contributor.authorTaglialatela-Scafati, Orazio
dc.date.accessioned2018-09-20T16:03:14Z
dc.date.available2018-09-20T16:03:14Z
dc.date.issued2013-08-28
dc.identifier.citationChianese, Giuseppina; Scala, Fernando; Calcinai, Barbara; Cerrano, Carlo; Dien, Henny; Kaiser, Marcel; Tasdemir, Deniz; Taglialatela-Scafati, Orazio (2013). Natural and semisynthetic analogues of manadoperoxide b reveal new structural requirements for trypanocidal activity. Marine Drugs 11 (9), 3297-3308
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10379/10772
dc.description.abstractChemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), bearing some interesting relationships with the polyketide endoperoxides found in this sponge. Some semi-synthetic analogues of manadoperoxide B (6-8) were prepared and evaluated for antitrypanosomal activity and cytotoxicity. These studies revealed crucial structure-activity relationships that should be taken into account in the design of optimized and simplified endoperoxyketal trypanocidal agents.
dc.publisherMDPI AG
dc.relation.ispartofMarine Drugs
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectmanadoperoxide b
dc.subjectmarine antitrypanosomals
dc.subjectstructure-activity relationships
dc.subjectsponge plakortis-simplex
dc.subjectdrug-resistance
dc.subjectin-vitro
dc.subjectcycloperoxides
dc.subjectmetabolites
dc.subjectparasites
dc.titleNatural and semisynthetic analogues of manadoperoxide b reveal new structural requirements for trypanocidal activity
dc.typeArticle
dc.identifier.doi10.3390/md11093297
dc.local.publishedsourcehttp://www.mdpi.com/1660-3397/11/9/3297/pdf
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland