Show simple item record

dc.contributor.authorCastro, Pedro
dc.contributor.authorSerrador, Jorge Manuel
dc.contributor.authorRocha, Isabel
dc.contributor.authorSorond, Farzaneh
dc.contributor.authorAzevedo, Elsa
dc.date.accessioned2018-09-20T16:02:54Z
dc.date.available2018-09-20T16:02:54Z
dc.date.issued2017-03-24
dc.identifier.citationCastro, Pedro; Serrador, Jorge Manuel; Rocha, Isabel; Sorond, Farzaneh; Azevedo, Elsa (2017). Efficacy of cerebral autoregulation in early ischemic stroke predicts smaller infarcts and better outcome. Frontiers in Neurology 8 ,
dc.identifier.issn1664-2295
dc.identifier.urihttp://hdl.handle.net/10379/10722
dc.description.abstractBackground and purpose: Effective cerebral autoregulation (CA) may protect the vulnerable ischemic penumbra from blood pressure fluctuations and minimize neurological injury. We aimed to measure dynamic CA within 6 h of ischemic stroke (IS) symptoms onset and to evaluate the relationship between CA, stroke volume, and neurological outcome. Methods: We enrolled 30 patients with acute middle cerebral artery IS. Within 6 h of IS, we measured for 10 min arterial blood pressure (Finometer), cerebral blood flow velocity (transcranial Doppler), and end-tidal-CO2. Transfer function analysis (coherence, phase, and gain) assessed dynamic CA, and receiver-operating curves calculated relevant cut-off values. National Institute of Health Stroke Scale was measured at baseline. Computed tomography at 24 h evaluated infarct volume. Modified Rankin Scale (MRS) at 3 months evaluated the outcome. Results: The odds of being independent at 3 months (MRS 0-2) was 14-fold higher when 6 h CA was intact (Phase > 37 degrees) (adjusted OR = 14.0 (IC 95% 1.7-74.0), p = 0.013). Similarly, infarct volume was significantly smaller with intact CA [median (range) 1.1 (0.2-7.0) vs 13.1 (1.3-110.5) ml, p = 0.002]. conclusion: In this pilot study, early effective CA was associated with better neurological outcome in patients with IS. Dynamic CA may carry significant prognostic implications.
dc.publisherFrontiers Media SA
dc.relation.ispartofFrontiers in Neurology
dc.subjectcerebral autoregulation
dc.subjectblood pressure
dc.subjectstroke
dc.subjectischemic stroke
dc.subjecttranscranial doppler
dc.subjectblood-pressure
dc.subjectintracerebral hemorrhage
dc.subjectautoregulation
dc.subjecthemodynamics
dc.subjectassociation
dc.titleEfficacy of cerebral autoregulation in early ischemic stroke predicts smaller infarcts and better outcome
dc.typeArticle
dc.identifier.doi10.3389/fneur.2017.00113
dc.local.publishedsourcehttps://www.frontiersin.org/articles/10.3389/fneur.2017.00113/pdf
nui.item.downloads0


Files in this item

This item appears in the following Collection(s)

Show simple item record