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dc.contributor.authorCarson, Matthew A.
dc.contributor.authorNelson, John
dc.contributor.authorCancela, M. Leonor
dc.contributor.authorLaizé, Vincent
dc.contributor.authorGavaia, Paulo J.
dc.contributor.authorRae, Margaret
dc.contributor.authorHeesch, Svenja
dc.contributor.authorVerzin, Eugene
dc.contributor.authorMaggs, Christine
dc.contributor.authorGilmore, Brendan F.
dc.contributor.authorClarke, Susan A.
dc.date.accessioned2018-09-20T16:02:49Z
dc.date.available2018-09-20T16:02:49Z
dc.date.issued2018-05-16
dc.identifier.citationCarson, Matthew A. Nelson, John; Cancela, M. Leonor; Laizé, Vincent; Gavaia, Paulo J.; Rae, Margaret; Heesch, Svenja; Verzin, Eugene; Maggs, Christine; Gilmore, Brendan F.; Clarke, Susan A. (2018). Red algal extracts from plocamium lyngbyanum and ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae. Scientific Reports 8 ,
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10379/10708
dc.description.abstractThrough the current trend for bioprospecting, marine organisms-particularly algae-are becoming increasingly known for their osteogenic potential. Such organisms may provide novel treatment options for osteoporosis and other musculoskeletal conditions, helping to address their large healthcare burden and the limitations of current therapies. In this study, extracts from two red algae-Plocamium lyngbyanum and Ceramium secundatum-were tested in vitro and in vivo for their osteogenic potential. In vitro, the growth of human bone marrow stromal cells (hBMSCs) was significantly greater in the presence of the extracts, particularly with P. lyngbyanum treatment. Osteogenic differentiation was promoted more by C. secundatum (70 mu g/ml), though P. lyngbyanum had greater in vitro mineralisation potential. Both species caused a marked and dose-dependent increase in the opercular bone area of zebrafish larvae. Our findings therefore indicate the presence of bioactive components in P. lyngbyanum and C. secundatum extracts, which can promote both in vitro and in vivo osteogenic activity.
dc.publisherSpringer Nature
dc.relation.ispartofScientific Reports
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectpostmenopausal osteoporosis
dc.subjectfracture risk
dc.subjectdifferentiation
dc.subjectcells
dc.subjectvivo
dc.subjectwomen
dc.subjectmacroalgae
dc.subjectfucoidan
dc.subjectmen
dc.titleRed algal extracts from plocamium lyngbyanum and ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae
dc.typeArticle
dc.identifier.doi10.1038/s41598-018-26024-0
dc.local.publishedsourcehttps://doi.org/10.1038/s41598-018-26024-0
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland