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dc.contributor.authorCaneschi, Carolina
dc.contributor.authorMuniyappa, Mohan
dc.contributor.authorDuarte, Lucienir
dc.contributor.authorSilva, Grcia
dc.contributor.authorSantos, Orlando
dc.contributor.authorSpillane, Charles
dc.contributor.authorFilho, Sidney
dc.date.accessioned2018-09-20T16:02:35Z
dc.date.available2018-09-20T16:02:35Z
dc.date.issued2015-01-01
dc.identifier.citationCaneschi, Carolina; Muniyappa, Mohan; Duarte, Lucienir; Silva, Grcia; Santos, Orlando; Spillane, Charles; Filho, Sidney (2015). Effect of constituents from samaras of austroplenckia populnea (celastraceae) on human cancer cells . Journal of Intercultural Ethnopharmacology 4 (1), 6-11
dc.identifier.issn2146-8397
dc.identifier.urihttp://hdl.handle.net/10379/10675
dc.description.abstractBackground: Aiming the continuity of the studies of Austroplenckia populnea, Brazilian species of the Celastraceae family, in the present study, it was investigated the effect of crude extracts obtained with ethanol, ethyl acetate and chloroform and two purified constituents, proanthocyanidin A and 4'-O-methylepigallocatechin, both isolated from its samaras, on cancer cell proliferation assays. Materials and Methods: The human cancer cells lines MCF-7 (ductal breast carcinoma), A549 (lung cancer), HS578T (ductal breast carcinoma) and non-cancer HEK293 (embryonic kidney cells) were treated with different concentrations of extracts and constituents and the effect was observed through the acid phosphatase method. The chemical structures of the purified compounds were identified by the respective IR and H-1 and C-13 nuclear magnetic resonance spectral data. Results: While crude extracts from samaras of the folk medicine A. populnea can trigger cell proliferative effects in human cell lines, the purified compounds (proanthocyanidin A and 4'-O-methyl-epigallocatechin) isolated from the same extracts can have an opposite (anti-proliferative) effect. Conclusion: Based on the results, it was possible to suggest that extracts from samaras of A. populnea should be further investigated for possible cancer-promoting activities; and the active extracts can also represent a source of compounds that have anti-cancer properties.
dc.publisherScopeMed International Medical Journal Management and Indexing System
dc.relation.ispartofJournal of Intercultural Ethnopharmacology
dc.subjectaustroplenckia populnea
dc.subjectcancer cell proliferation
dc.subjectcelastraceae
dc.subjectsamaras
dc.subjectmaytenus-ilicifolia
dc.subjectmelanoma-cells
dc.subjectantioxidant
dc.subjectbark
dc.subjecttriterpenes
dc.subjectfractions
dc.subjectextracts
dc.subjectrats
dc.titleEffect of constituents from samaras of austroplenckia populnea (celastraceae) on human cancer cells
dc.typeArticle
dc.identifier.doi10.5455/jice.20141006105747
dc.local.publishedsourcehttps://doi.org/10.5455/jice.20141006105747
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