dc.contributor.author | Berman, Peter | |
dc.contributor.author | Collins, Malcolm | |
dc.contributor.author | Baumgarten, Ingrid | |
dc.contributor.author | Seoighe, Cathal | |
dc.contributor.author | Jennings, Courtney L. | |
dc.contributor.author | Joffe, Yael | |
dc.contributor.author | Lambert, Estelle V. | |
dc.contributor.author | Levitt, Naomi S. | |
dc.contributor.author | Faulenbach, Mirjam V. | |
dc.contributor.author | Kahn, Steven E. | |
dc.contributor.author | Goedecke, Julia H. | |
dc.date.accessioned | 2018-09-20T16:00:56Z | |
dc.date.available | 2018-09-20T16:00:56Z | |
dc.date.issued | 2009-02-26 | |
dc.identifier.citation | Berman, Peter; Collins, Malcolm; Baumgarten, Ingrid; Seoighe, Cathal; Jennings, Courtney L. Joffe, Yael; Lambert, Estelle V.; Levitt, Naomi S.; Faulenbach, Mirjam V.; Kahn, Steven E.; Goedecke, Julia H. (2009). Association between the 4 bp proinsulin gene insertion polymorphism (ivs-69) and body composition in black south african women. Obesity 17 (6), 1298-1300 | |
dc.identifier.issn | 1930-7381,1930-739X | |
dc.identifier.uri | http://hdl.handle.net/10379/10416 | |
dc.description.abstract | The objective of the study was to examine the association between a functional 4 bp proinsulin gene insertion polymorphism (IVS-69), fasting insulin concentrations, and body composition in black South African women. Body composition, body fat distribution, fasting glucose and insulin concentrations, and IVS-69 genotype were measured in 115 normal-weight (BMI < 25 kg/ m(2)) and 138 obese (BMI >= 30 kg/m(2)) premenopausal women. The frequency of the insertion allele was significantly higher in the class 2 obese (BMI >= 35kg/m(2)) compared with the normal-weight group (P = 0.029). Obese subjects with the insertion allele had greater fat mass (42.3 +/- 0.9 vs. 38.9 +/- 0.9 kg, P = 0.034) and fat-free soft tissue mass (47.4 +/- 0.6 vs. 45.1 +/- 0.6 kg, P = 0.014), and more abdominal subcutaneous adipose tissue (SAT, 595 +/- 17 vs. 531 +/- 17 cm(2), P = 0.025) but not visceral fat (P = 0.739), than obese homozygotes for the wild-type allele. Only SAT was greater in normal-weight subjects with the insertion allele (P = 0.048). There were no differences in fasting insulin or glucose levels between subjects with the insertion allele or homozygotes for the wild-type allele in the normal-weight or obese groups. In conclusion, the 4 bp proinsulin gene insertion allele is associated with extreme obesity, reflected by greater fat-free soft tissue mass and fat mass, particularly SAT, in obese black South African women. | |
dc.publisher | Wiley-Blackwell | |
dc.relation.ispartof | Obesity | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | splice-variant | |
dc.subject | obesity | |
dc.subject | translation | |
dc.title | Association between the 4 bp proinsulin gene insertion polymorphism (ivs-69) and body composition in black south african women | |
dc.type | Article | |
dc.identifier.doi | 10.1038/oby.2009.40 | |
dc.local.publishedsource | http://onlinelibrary.wiley.com/doi/10.1038/oby.2009.40/pdf | |
nui.item.downloads | 0 | |