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dc.contributor.authorBansode, Vijay
dc.contributor.authorDrebert, Zuzanna J.
dc.contributor.authorTravers, Simon A.A.
dc.contributor.authorBanda, Emmanuel
dc.contributor.authorMolesworth, Anna
dc.contributor.authorCrampin, Amelia
dc.contributor.authorNgwira, Bagrey
dc.contributor.authorFrench, Neil
dc.contributor.authorGlynn, Judith R.
dc.contributor.authorMcCormack, Grace P.
dc.identifier.citationBansode, Vijay; Drebert, Zuzanna J. Travers, Simon A.A.; Banda, Emmanuel; Molesworth, Anna; Crampin, Amelia; Ngwira, Bagrey; French, Neil; Glynn, Judith R.; McCormack, Grace P. (2011). Drug resistance mutations in drug-naive hiv type 1 subtype c-infected individuals from rural malawi. AIDS Research and Human Retroviruses 27 (4), 439-444
dc.description.abstractIn this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major and minor drug resistance mutations (DRMs). From a sample size of 40 reverse transcriptase (RT) consensus sequences from drug-naive individuals we found five showing NRTI and four showing NNRTI mutations with one individual showing both. From 29 protease consensus sequences, again from drug-naive individuals, we found evidence of minor DRMs in three. Additional major and minor DRMs were found in clonal sequences from a number of individuals that were not present in the original consensus sequences. This clearly illustrates the importance of sequencing multiple HIV-1 variants from individuals to fully assess drug resistance.
dc.publisherMary Ann Liebert Inc
dc.relation.ispartofAIDS Research and Human Retroviruses
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.titleDrug resistance mutations in drug-naive hiv type 1 subtype c-infected individuals from rural malawi

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