dc.contributor.author | Bansode, Vijay | |
dc.contributor.author | Drebert, Zuzanna J. | |
dc.contributor.author | Travers, Simon A.A. | |
dc.contributor.author | Banda, Emmanuel | |
dc.contributor.author | Molesworth, Anna | |
dc.contributor.author | Crampin, Amelia | |
dc.contributor.author | Ngwira, Bagrey | |
dc.contributor.author | French, Neil | |
dc.contributor.author | Glynn, Judith R. | |
dc.contributor.author | McCormack, Grace P. | |
dc.date.accessioned | 2018-09-20T16:00:27Z | |
dc.date.available | 2018-09-20T16:00:27Z | |
dc.date.issued | 2011-04-01 | |
dc.identifier.citation | Bansode, Vijay; Drebert, Zuzanna J. Travers, Simon A.A.; Banda, Emmanuel; Molesworth, Anna; Crampin, Amelia; Ngwira, Bagrey; French, Neil; Glynn, Judith R.; McCormack, Grace P. (2011). Drug resistance mutations in drug-naive hiv type 1 subtype c-infected individuals from rural malawi. AIDS Research and Human Retroviruses 27 (4), 439-444 | |
dc.identifier.issn | 0889-2229,1931-8405 | |
dc.identifier.uri | http://hdl.handle.net/10379/10343 | |
dc.description.abstract | In this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major and minor drug resistance mutations (DRMs). From a sample size of 40 reverse transcriptase (RT) consensus sequences from drug-naive individuals we found five showing NRTI and four showing NNRTI mutations with one individual showing both. From 29 protease consensus sequences, again from drug-naive individuals, we found evidence of minor DRMs in three. Additional major and minor DRMs were found in clonal sequences from a number of individuals that were not present in the original consensus sequences. This clearly illustrates the importance of sequencing multiple HIV-1 variants from individuals to fully assess drug resistance. | |
dc.publisher | Mary Ann Liebert Inc | |
dc.relation.ispartof | AIDS Research and Human Retroviruses | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | reverse-transcriptase | |
dc.subject | protease | |
dc.title | Drug resistance mutations in drug-naive hiv type 1 subtype c-infected individuals from rural malawi | |
dc.type | Article | |
dc.identifier.doi | 10.1089/aid.2010.0203 | |
dc.local.publishedsource | http://europepmc.org/articles/pmc3068870?pdf=render | |
nui.item.downloads | 0 | |