Drug resistance mutations in drug-naive hiv type 1 subtype c-infected individuals from rural malawi
Drebert, Zuzanna J.
Travers, Simon A.A.
Glynn, Judith R.
McCormack, Grace P.
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Bansode, Vijay; Drebert, Zuzanna J. Travers, Simon A.A.; Banda, Emmanuel; Molesworth, Anna; Crampin, Amelia; Ngwira, Bagrey; French, Neil; Glynn, Judith R.; McCormack, Grace P. (2011). Drug resistance mutations in drug-naive hiv type 1 subtype c-infected individuals from rural malawi. AIDS Research and Human Retroviruses 27 (4), 439-444
In this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major and minor drug resistance mutations (DRMs). From a sample size of 40 reverse transcriptase (RT) consensus sequences from drug-naive individuals we found five showing NRTI and four showing NNRTI mutations with one individual showing both. From 29 protease consensus sequences, again from drug-naive individuals, we found evidence of minor DRMs in three. Additional major and minor DRMs were found in clonal sequences from a number of individuals that were not present in the original consensus sequences. This clearly illustrates the importance of sequencing multiple HIV-1 variants from individuals to fully assess drug resistance.