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dc.contributor.authorBallester-Beltrán, José
dc.contributor.authorBiggs, Manus J. P.
dc.contributor.authorDalby, Matthew J.
dc.contributor.authorSalmerón-Sánchez, Manuel
dc.contributor.authorLeal-Egaña, Aldo
dc.identifier.citationBallester-Beltrán, José; Biggs, Manus J. P. Dalby, Matthew J.; Salmerón-Sánchez, Manuel; Leal-Egaña, Aldo (2015). Sensing the difference: the influence of anisotropic cues on cell behavior. Frontiers in Materials ,
dc.description.abstractFrom tissue morphogenesis to homeostasis, cells continuously experience and respond to physical, chemical, and biological cues commonly presented in gradients. In this article, we focus our discussion on the importance of nano/micro topographic cues on cell activity, and the role of anisotropic milieus play on cell behavior, mostly adhesion and migration. We present the need to study physiological gradients in vitro. To do this, we review different cell migration mechanisms and how adherent cells react to the presence of complex tissue-like environments and cell-surface stimulation in 2D and 3D (e.g., ventral/dorsal anisotropy).
dc.publisherFrontiers Media SA
dc.relation.ispartofFrontiers in Materials
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectsurface topography
dc.subjectanisotropic materials
dc.subjectcell-biomaterial interface
dc.subjectcell-matrix anchorage
dc.subjecttopographical cues
dc.titleSensing the difference: the influence of anisotropic cues on cell behavior

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