dc.contributor.author | Balasundaram, Ghayathri | |
dc.contributor.author | Ho, Chris Jun Hui | |
dc.contributor.author | Li, Kai | |
dc.contributor.author | Driessen, Wouter | |
dc.contributor.author | Dinish, U | |
dc.contributor.author | Wong, Chi Lok | |
dc.contributor.author | Ntziachristos, Vasilis | |
dc.contributor.author | Liu, Bin | |
dc.contributor.author | Olivo, Malini | |
dc.date.accessioned | 2018-09-20T16:00:22Z | |
dc.date.available | 2018-09-20T16:00:22Z | |
dc.date.issued | 2015-01-01 | |
dc.identifier.citation | Balasundaram, Ghayathri; Ho, Chris Jun Hui; Li, Kai; Driessen, Wouter; Dinish, U; Wong, Chi Lok; Ntziachristos, Vasilis; Liu, Bin; Olivo, Malini (2015). Molecular photoacoustic imaging of breast cancer using an actively targeted conjugated polymer. International Journal of Nanomedicine 10 , 387-397 | |
dc.identifier.issn | 1178-2013 | |
dc.identifier.uri | http://hdl.handle.net/10379/10330 | |
dc.description.abstract | Conjugated polymers (CPs) are upcoming optical contrast agents in view of their unique optical properties and versatile synthetic chemistry. Biofunctionalization of these polymer-based nanoparticles enables molecular imaging of biological processes. In this work, we propose the concept of using a biofunctionalized CP for noninvasive photoacoustic (PA) molecular imaging of breast cancer. In particular, after verifying the PA activity of a CP nanoparticle (CP dots) in phantoms and the targeting efficacy of a folate-functionalized version of the same (folate-CP dots) in vitro, we systemically administered the probe into a folate receptor-positive (FR+ve) MCF-7 breast cancer xenograft model to demonstrate the possible application of folate-CP dots for imaging FR+ve breast cancers in comparison to CP dots with no folate moieties. We observed a strong PA signal at the tumor site of folate-CP dots-administered mice as early as 1 hour after administration as a result of the active targeting of the folate-CP dots to the FR+ve tumor cells but a weak PA signal at the tumor site of CP-dots-administered mice as a result of the passive accumulation of the probe by enhanced permeability and retention effect. We also observed that folate-CP dots produced similar to 4-fold enhancement in the PA signal in the tumor, when compared to CP dots. These observations demonstrate the great potential of this active-targeting CP to be used as a contrast agent for molecular PA diagnostic imaging in various biomedical applications. | |
dc.publisher | Dove Medical Press Ltd. | |
dc.relation.ispartof | International Journal of Nanomedicine | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | photoacoustic tomography | |
dc.subject | conjugated polymers | |
dc.subject | molecular imaging | |
dc.subject | breast cancer | |
dc.subject | multispectral optoacoustic tomography | |
dc.subject | in-vivo | |
dc.subject | gold nanorods | |
dc.subject | living mice | |
dc.subject | contrast agents | |
dc.subject | nanoparticles | |
dc.subject | fluorescence | |
dc.subject | cells | |
dc.title | Molecular photoacoustic imaging of breast cancer using an actively targeted conjugated polymer | |
dc.type | Article | |
dc.identifier.doi | 10.2147/ijn.s73558 | |
dc.local.publishedsource | https://www.dovepress.com/getfile.php?fileID=23147 | |
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