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dc.contributor.authorAvanzi, Charlotte
dc.contributor.authordel-Pozo, Jorge
dc.contributor.authorBenjak, Andrej
dc.contributor.authorStevenson, Karen
dc.contributor.authorSimpson, Victor R.
dc.contributor.authorBusso, Philippe
dc.contributor.authorMcLuckie, Joyce
dc.contributor.authorLoiseau, Chloé
dc.contributor.authorLawton, Colin
dc.contributor.authorSchoening, Janne
dc.contributor.authorShaw, Darren J.
dc.contributor.authorPiton, Jérémie
dc.contributor.authorVera-Cabrera, Lucio
dc.contributor.authorVelarde-Felix, Jesùs S.
dc.contributor.authorMcDermott, Fergal
dc.contributor.authorGordon, Stephen V.
dc.contributor.authorCole, Stewart T.
dc.contributor.authorMeredith, Anna L.
dc.date.accessioned2018-09-20T16:00:14Z
dc.date.available2018-09-20T16:00:14Z
dc.date.issued2016-11-10
dc.identifier.citationAvanzi, Charlotte; del-Pozo, Jorge; Benjak, Andrej; Stevenson, Karen; Simpson, Victor R. Busso, Philippe; McLuckie, Joyce; Loiseau, Chloé; Lawton, Colin; Schoening, Janne; Shaw, Darren J.; Piton, Jérémie; Vera-Cabrera, Lucio; Velarde-Felix, Jesùs S.; McDermott, Fergal; Gordon, Stephen V.; Cole, Stewart T.; Meredith, Anna L. (2016). Red squirrels in the british isles are infected with leprosy bacilli. Science 354 (6313), 744-747
dc.identifier.issn0036-8075,1095-9203
dc.identifier.urihttp://hdl.handle.net/10379/10310
dc.description.abstractLeprosy, caused by infection with Mycobacterium leprae or the recently discovered Mycobacterium lepromatosis, was once endemic in humans in the British Isles. Red squirrels in Great Britain (Sciurus vulgaris) have increasingly been observed with leprosy-like lesions on the head and limbs. Using genomics, histopathology, and serology, we found M. lepromatosis in squirrels from England, Ireland, and Scotland, and M. leprae in squirrels from Brownsea Island, England. Infection was detected in overtly diseased and seemingly healthy animals. Phylogenetic comparisons of British and Irish M. lepromatosis with two Mexican strains from humans show that they diverged from a common ancestor around 27,000 years ago, whereas the M. leprae strain is closest to one that circulated in Medieval England. Red squirrels are thus a reservoir for leprosy in the British Isles.
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.relation.ispartofScience
dc.subjectmycobacterium-lepromatosis
dc.subjectzoonotic leprosy
dc.subjectunited-states
dc.subjectleprae
dc.subjectmedieval
dc.titleRed squirrels in the british isles are infected with leprosy bacilli
dc.typeArticle
dc.identifier.doi10.1126/science.aah3783
dc.local.publishedsourcehttps://infoscience.epfl.ch/record/222947/files/Avanzi.SM.pdf
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