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dc.contributor.authorAnsboro, S
dc.contributor.author,
dc.contributor.authorGreiser, U
dc.contributor.authorBarry, F
dc.contributor.authorMurphy, M
dc.date.accessioned2018-09-20T15:59:52Z
dc.date.available2018-09-20T15:59:52Z
dc.date.issued2012-04-21
dc.identifier.citationAnsboro, S; , ; Greiser, U; Barry, F; Murphy, M (2012). Strategies for improved targeting of therapeutic cells: implications for tissue repair. European Cells and Materials 23 , 310-319
dc.identifier.issn
dc.identifier.urihttp://hdl.handle.net/10379/10259
dc.description.abstractMultipotent mesenchymal stem cells (MSCs) have been suggested as a suitable cell source for cell-based treatments for diseases such as osteoarthritis due to their ability to differentiate towards chondrogenic and osteogenic lineages. MSCs can be obtained from a variety of tissue sources, are scalable for mass-production and immuno-privileged enabling their use for allogeneic cell therapy. However, recent pre-clinical studies and clinical trials point to the necessity of increasing engraftment and efficacy of MSCs. This review explores how cell surface modification of the cells can improve homing of MSCs and summarises the use of nanoparticles to enable gene delivery by stem cells as well as facilitate in vivo imaging. The use of advanced biomaterials and how they can be applied to reduce the overall dose of MSCs during therapeutic interventions while achieving optimal targeting efficiency of cells to the diseased sites are addressed. Particular attention is paid to methods that improve engraftment of MSCs to cartilage and research describing combinatorial approaches of particle-based cell therapies for improved regeneration of this tissue is reviewed. The use of such approaches will add to the array of potential regenerative therapeutics for treatment of osteoarthritis.
dc.publisherECM Research Journal
dc.relation.ispartofEuropean Cells and Materials
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectmesenchymal stem cells
dc.subjectchondrocytes
dc.subjectnanoparticles
dc.subjecttargeting approaches
dc.subjectcell surface markers
dc.subjectcartilage repair
dc.subjectosteoarthritis
dc.subjectregenerative medicine
dc.subjectmesenchymal stem-cells
dc.subjectinflammatory-bowel-disease
dc.subjecthuman bone-marrow
dc.subjectinfarcted myocardium
dc.subjectplga nanoparticles
dc.subjectsynovial-membrane
dc.subjectalpha-4 integrin
dc.subjectin-vivo
dc.subjectdelivery
dc.subjectcartilage
dc.titleStrategies for improved targeting of therapeutic cells: implications for tissue repair
dc.typeArticle
dc.identifier.doi10.22203/ecm.v023a24
dc.local.publishedsourcehttp://doi.org/10.22203/ecm.v023a24
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland