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dc.contributor.authorAhmed, Albin
dc.contributor.authorSebastiano, Simone
dc.contributor.authorSweeney, Torres
dc.contributor.authorHanrahan, James
dc.contributor.authorGlynn, Assumpta
dc.contributor.authorKeane, Orla
dc.contributor.authorMukhopadhya, Anindya
dc.contributor.authorThornton, Kevin
dc.contributor.authorGood, Barbara
dc.date.accessioned2018-09-20T15:59:15Z
dc.date.available2018-09-20T15:59:15Z
dc.date.issued2015-01-01
dc.identifier.citationAhmed, Albin; Sebastiano, Simone; Sweeney, Torres; Hanrahan, James; Glynn, Assumpta; Keane, Orla; Mukhopadhya, Anindya; Thornton, Kevin; Good, Barbara (2015). Breed differences in humoral and cellular responses of lambs to experimental infection with the gastrointestinal nematode teladorsagia circumcincta. Veterinary Research 46 ,
dc.identifier.issn1297-9716
dc.identifier.urihttp://hdl.handle.net/10379/10171
dc.description.abstractWhile Texel lambs have increased resistance to infection with the gastrointestinal nematode Teladorsagia circumcincta compared to Suffolk lambs, the underlying resistance mechanisms are still unknown. The aim of this study was to compare parasitological, humoral and cellular responses of Texel and Suffolk lambs over time following a single experimental infection with T. circumcincta. Gastrointestinal nematode free (but not naive) lambs received a single oral dose of 3 x 10(4) infective T. circumcincta larvae. The variables examined included worm burden, mucosal and serum IgA, abomasal mast cells and eosinophils, haematological parameters and plasma pepsinogen. Texel lambs had significantly lower worm burden on day 14 and lower plasma pepsinogen concentration from day 14 onwards than Suffolks and their response in mucosal IgA to infection occurred earlier. The results from the study suggest that an earlier local IgA response in the Texel contributes to the resistant characteristics of the breed, while the increased level of plasma pepsinogen in the Suffolk lambs implies greater abomasal tissue damage arising from the nematode infection.
dc.publisherSpringer Nature
dc.relation.ispartofVeterinary Research
dc.subjectfecal egg counts
dc.subjectostertagia-circumcincta
dc.subjecthaemonchus-contortus
dc.subjectinhibited development
dc.subjectsheep
dc.subjectresistance
dc.subjectruminants
dc.subjectplatelets
dc.subjectimmunity
dc.subjectparasites
dc.titleBreed differences in humoral and cellular responses of lambs to experimental infection with the gastrointestinal nematode teladorsagia circumcincta
dc.typeArticle
dc.identifier.doi10.1186/s13567-014-0137-0
dc.local.publishedsourcehttp://doi.org/10.1186/s13567-014-0137-0
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