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Novel genetic loci underlying human intracranial volume identified through genome-wide association

dc.contributor.authorAdams, Hieab H H
dc.contributor.authorHibar, Derrek P
dc.contributor.authorChouraki, Vincent
dc.contributor.authorStein, Jason L
dc.contributor.authorNyquist, Paul A
dc.contributor.authorRentería, Miguel E
dc.contributor.authorTrompet, Stella
dc.contributor.authorArias-Vasquez, Alejandro
dc.contributor.authorSeshadri, Sudha
dc.contributor.authorDesrivières, Sylvane
dc.contributor.authorBeecham, Ashley H
dc.contributor.authorJahanshad, Neda
dc.contributor.authorWittfeld, Katharina
dc.contributor.authorVan der Lee, Sven J
dc.contributor.authorAbramovic, Lucija
dc.contributor.authorAlhusaini, Saud
dc.contributor.authorAmin, Najaf
dc.contributor.authorAndersson, Micael
dc.contributor.authorArfanakis, Konstantinos
dc.contributor.authorAribisala, Benjamin S
dc.contributor.authorArmstrong, Nicola J
dc.contributor.authorAthanasiu, Lavinia
dc.contributor.authorAxelsson, Tomas
dc.contributor.authorBeiser, Alexa
dc.contributor.authorBernard, Manon
dc.contributor.authorBis, Joshua C
dc.contributor.authorBlanken, Laura M E
dc.contributor.authorBlanton, Susan H
dc.contributor.authorBohlken, Marc M
dc.contributor.authorBoks, Marco P
dc.contributor.authorBralten, Janita
dc.contributor.authorBrickman, Adam M
dc.contributor.authorCarmichael, Owen
dc.contributor.authorChakravarty, M Mallar
dc.contributor.authorChauhan, Ganesh
dc.contributor.authorChen, Qiang
dc.contributor.authorChing, Christopher R K
dc.contributor.authorCuellar-Partida, Gabriel
dc.contributor.authorBraber, Anouk Den
dc.contributor.authorDoan, Nhat Trung
dc.contributor.authorEhrlich, Stefan
dc.contributor.authorFilippi, Irina
dc.contributor.authorGe, Tian
dc.contributor.authorGiddaluru, Sudheer
dc.contributor.authorGoldman, Aaron L
dc.contributor.authorGottesman, Rebecca F
dc.contributor.authorGreven, Corina U
dc.contributor.authorGrimm, Oliver
dc.contributor.authorGriswold, Michael E
dc.contributor.authorGuadalupe, Tulio
dc.contributor.authorHass, Johanna
dc.contributor.authorHaukvik, Unn K
dc.contributor.authorHilal, Saima
dc.contributor.authorHofer, Edith
dc.contributor.authorHoehn, David
dc.contributor.authorHolmes, Avram J
dc.contributor.authorHoogman, Martine
dc.contributor.authorJanowitz, Deborah
dc.contributor.authorJia, Tianye
dc.contributor.authorKasperaviciute, Dalia
dc.contributor.authorKim, Sungeun
dc.contributor.authorKlein, Marieke
dc.contributor.authorKraemer, Bernd
dc.contributor.authorLee, Phil H
dc.contributor.authorLiao, Jiemin
dc.contributor.authorLiewald, David C M
dc.contributor.authorLopez, Lorna M
dc.contributor.authorLuciano, Michelle
dc.contributor.authorMacare, Christine
dc.contributor.authorMarquand, Andre
dc.contributor.authorMatarin, Mar
dc.contributor.authorMather, Karen A
dc.contributor.authorMattheisen, Manuel
dc.contributor.authorMazoyer, Bernard
dc.contributor.authorMcKay, David R
dc.contributor.authorMcWhirter, Rebekah
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorMirza-Schreiber, Nazanin
dc.contributor.authorMuetzel, Ryan L
dc.contributor.authorManiega, Susana Muñoz
dc.contributor.authorNho, Kwangsik
dc.contributor.authorNugent, Allison C
dc.contributor.authorLoohuis, Loes M Olde
dc.contributor.authorOosterlaan, Jaap
dc.contributor.authorPapmeyer, Martina
dc.contributor.authorPappa, Irene
dc.contributor.authorPirpamer, Lukas
dc.contributor.authorPudas, Sara
dc.contributor.authorPütz, Benno
dc.contributor.authorRajan, Kumar B
dc.contributor.authorRamasamy, Adaikalavan
dc.contributor.authorRichards, Jennifer S
dc.contributor.authorRisacher, Shannon L
dc.contributor.authorRoiz-Santiañez, Roberto
dc.contributor.authorRommelse, Nanda
dc.contributor.authorRose, Emma J
dc.contributor.authorRoyle, Natalie A
dc.contributor.authorRundek, Tatjana
dc.contributor.authorSämann, Philipp G
dc.contributor.authorSatizabal, Claudia L
dc.contributor.authorSchmaal, Lianne
dc.contributor.authorSchork, Andrew J
dc.contributor.authorShen, Li
dc.contributor.authorShin, Jean
dc.contributor.authorShumskaya, Elena
dc.contributor.authorSmith, Albert V
dc.contributor.authorSprooten, Emma
dc.contributor.authorStrike, Lachlan T
dc.contributor.authorTeumer, Alexander
dc.contributor.authorThomson, Russell
dc.contributor.authorTordesillas-Gutierrez, Diana
dc.contributor.authorToro, Roberto
dc.contributor.authorTrabzuni, Daniah
dc.contributor.authorVaidya, Dhananjay
dc.contributor.authorVan der Grond, Jeroen
dc.contributor.authorVan der Meer, Dennis
dc.contributor.authorVan Donkelaar, Marjolein M J
dc.contributor.authorVan Eijk, Kristel R
dc.contributor.authorVan Erp, Theo G M
dc.contributor.authorVan Rooij, Daan
dc.contributor.authorWalton, Esther
dc.contributor.authorWestlye, Lars T
dc.contributor.authorWhelan, Christopher D
dc.contributor.authorWindham, Beverly G
dc.contributor.authorWinkler, Anderson M
dc.contributor.authorWoldehawariat, Girma
dc.contributor.authorWolf, Christiane
dc.contributor.authorWolfers, Thomas
dc.contributor.authorXu, Bing
dc.contributor.authorYanek, Lisa R
dc.contributor.authorYang, Jingyun
dc.contributor.authorZijdenbos, Alex
dc.contributor.authorZwiers, Marcel P
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorAggarwal, Neelum T
dc.contributor.authorAlmasy, Laura
dc.contributor.authorAmes, David
dc.contributor.authorAmouyel, Philippe
dc.contributor.authorAndreassen, Ole A
dc.contributor.authorArepalli, Sampath
dc.contributor.authorAssareh, Amelia A
dc.contributor.authorBarral, Sandra
dc.contributor.authorBastin, Mark E
dc.contributor.authorBecker, Diane M
dc.contributor.authorBecker, James T
dc.contributor.authorBennett, David A
dc.contributor.authorBlangero, John
dc.contributor.authorvan Bokhoven, Hans
dc.contributor.authorBoomsma, Dorret I
dc.contributor.authorBrodaty, Henry
dc.contributor.authorBrouwer, Rachel M
dc.contributor.authorBrunner, Han G
dc.contributor.authorBuckner, Randy L
dc.contributor.authorBuitelaar, Jan K
dc.contributor.authorBulayeva, Kazima B
dc.contributor.authorCahn, Wiepke
dc.contributor.authorCalhoun, Vince D
dc.contributor.authorCannon, Dara M.
dc.contributor.authorCavalleri, Gianpiero L
dc.contributor.authorChen, Christopher
dc.contributor.authorCheng, Ching-Yu
dc.contributor.authorCichon, Sven
dc.contributor.authorCookson, Mark R
dc.contributor.authorCorvin, Aiden
dc.contributor.authorCrespo-Facorro, Benedicto
dc.contributor.authorCurran, Joanne E
dc.contributor.authorCzisch, Michael
dc.contributor.authorDale, Anders M
dc.contributor.authorDavies, Gareth E
dc.contributor.authorDe Geus, Eco J C
dc.contributor.authorDe Jager, Philip L
dc.contributor.authorde Zubicaray, Greig I
dc.contributor.authorDelanty, Norman
dc.contributor.authorDepondt, Chantal
dc.contributor.authorDeStefano, Anita L
dc.contributor.authorDillman, Allissa
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorDonohoe, Gary
dc.contributor.authorDrevets, Wayne C
dc.contributor.authorDuggirala, Ravi
dc.contributor.authorDyer, Thomas D
dc.contributor.authorErk, Susanne
dc.contributor.authorEspeseth, Thomas
dc.contributor.authorEvans, Denis A
dc.contributor.authorFedko, Iryna O
dc.contributor.authorFernández, Guillén
dc.contributor.authorFerrucci, Luigi
dc.contributor.authorFisher, Simon E
dc.contributor.authorFleischman, Debra A
dc.contributor.authorFord, Ian
dc.contributor.authorForoud, Tatiana M
dc.contributor.authorFox, Peter T
dc.contributor.authorFrancks, Clyde
dc.contributor.authorFukunaga, Masaki
dc.contributor.authorGibbs, J Raphael
dc.contributor.authorGlahn, David C
dc.contributor.authorGollub, Randy L
dc.contributor.authorGöring, Harald H H
dc.contributor.authorGrabe, Hans J
dc.contributor.authorGreen, Robert C
dc.contributor.authorGruber, Oliver
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorGuelfi, Sebastian
dc.contributor.authorHansell, Narelle K
dc.contributor.authorHardy, John
dc.contributor.authorHartman, Catharina A
dc.contributor.authorHashimoto, Ryota
dc.contributor.authorHegenscheid, Katrin
dc.contributor.authorHeinz, Andreas
dc.contributor.authorLe Hellard, Stephanie
dc.contributor.authorHernandez, Dena G
dc.contributor.authorHeslenfeld, Dirk J
dc.contributor.authorHo, Beng-Choon
dc.contributor.authorHoekstra, Pieter J
dc.contributor.authorHoffmann, Wolfgang
dc.contributor.authorHofman, Albert
dc.contributor.authorHolsboer, Florian
dc.contributor.authorHomuth, Georg
dc.contributor.authorHosten, Norbert
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorPol, Hilleke E Hulshoff
dc.contributor.authorIkeda, Masashi
dc.contributor.authorIkram, M Kamran
dc.contributor.authorJack, Clifford R
dc.contributor.authorJenkinson, Mark
dc.contributor.authorJohnson, Robert
dc.contributor.authorJönsson, Erik G
dc.contributor.authorJukema, J Wouter
dc.contributor.authorKahn, René S
dc.contributor.authorKanai, Ryota
dc.contributor.authorKloszewska, Iwona
dc.contributor.authorKnopman, David S
dc.contributor.authorKochunov, Peter
dc.contributor.authorKwok, John B
dc.contributor.authorLawrie, Stephen M
dc.contributor.authorLemaître, Hervé
dc.contributor.authorLiu, Xinmin
dc.contributor.authorLongo, Dan L
dc.contributor.authorLongstreth, W T
dc.contributor.authorLopez, Oscar L
dc.contributor.authorLovestone, Simon
dc.contributor.authorMartinez, Oliver
dc.contributor.authorMartinot, Jean-Luc
dc.contributor.authorMattay, Venkata S
dc.contributor.authorMcDonald, Colm
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorMcMahon, Katie L
dc.contributor.authorMcMahon, Francis J
dc.contributor.authorMecocci, Patrizia
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMeyer-Lindenberg, Andreas
dc.contributor.authorMohnke, Sebastian
dc.contributor.authorMontgomery, Grant W
dc.contributor.authorMorris, Derek W.
dc.contributor.authorMosley, Thomas H
dc.contributor.authorMühleisen, Thomas W
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorNalls, Michael A
dc.contributor.authorNauck, Matthias
dc.contributor.authorNichols, Thomas E
dc.contributor.authorNiessen, Wiro J
dc.contributor.authorNöthen, Markus M
dc.contributor.authorNyberg, Lars
dc.contributor.authorOhi, Kazutaka
dc.contributor.authorOlvera, Rene L
dc.contributor.authorOphoff, Roel A
dc.contributor.authorPandolfo, Massimo
dc.contributor.authorPaus, Tomas
dc.contributor.authorPausova, Zdenka
dc.contributor.authorPenninx, Brenda W J H
dc.contributor.authorPike, G Bruce
dc.contributor.authorPotkin, Steven G
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorReppermund, Simone
dc.contributor.authorRietschel, Marcella
dc.contributor.authorRoffman, Joshua L
dc.contributor.authorRomanczuk-Seiferth, Nina
dc.contributor.authorRotter, Jerome I
dc.contributor.authorRyten, Mina
dc.contributor.authorSacco, Ralph L
dc.contributor.authorSachdev, Perminder S
dc.contributor.authorSaykin, Andrew J
dc.contributor.authorSchmidt, Reinhold
dc.contributor.authorSchofield, Peter R
dc.contributor.authorSigurdsson, Sigurdur
dc.contributor.authorSimmons, Andy
dc.contributor.authorSingleton, Andrew
dc.contributor.authorSisodiya, Sanjay M
dc.contributor.authorSmith, Colin
dc.contributor.authorSmoller, Jordan W
dc.contributor.authorSoininen, Hilkka
dc.contributor.authorSrikanth, Velandai
dc.contributor.authorSteen, Vidar M
dc.contributor.authorStott, David J
dc.contributor.authorSussmann, Jessika E
dc.contributor.authorThalamuthu, Anbupalam
dc.contributor.authorTiemeier, Henning
dc.contributor.authorToga, Arthur W
dc.contributor.authorTraynor, Bryan J
dc.contributor.authorTroncoso, Juan
dc.contributor.authorTurner, Jessica A
dc.contributor.authorTzourio, Christophe
dc.contributor.authorUitterlinden, Andre G
dc.contributor.authorHernández, Maria C Valdés
dc.contributor.authorVan der Brug, Marcel
dc.contributor.authorVan der Lugt, Aad
dc.contributor.authorVan der Wee, Nic J A
dc.contributor.authorVan Duijn, Cornelia M
dc.contributor.authorVan Haren, Neeltje E M
dc.contributor.authorVan ′t Ent, Dennis
dc.contributor.authorVan Tol, Marie-Jose
dc.contributor.authorVardarajan, Badri N
dc.contributor.authorVeltman, Dick J
dc.contributor.authorVernooij, Meike W
dc.contributor.authorVölzke, Henry
dc.contributor.authorWalter, Henrik
dc.contributor.authorWardlaw, Joanna M
dc.contributor.authorWassink, Thomas H
dc.contributor.authorWeale, Michael E
dc.contributor.authorWeinberger, Daniel R
dc.contributor.authorWeiner, Michael W
dc.contributor.authorWen, Wei
dc.contributor.authorWestman, Eric
dc.contributor.authorWhite, Tonya
dc.contributor.authorWong, Tien Y
dc.contributor.authorWright, Clinton B
dc.contributor.authorZielke, H Ronald
dc.contributor.authorZonderman, Alan B
dc.contributor.authorDeary, Ian J
dc.contributor.authorDeCarli, Charles
dc.contributor.authorSchmidt, Helena
dc.contributor.authorMartin, Nicholas G
dc.contributor.authorDe Craen, Anton J M
dc.contributor.authorWright, Margaret J
dc.contributor.authorLauner, Lenore J
dc.contributor.authorSchumann, Gunter
dc.contributor.authorFornage, Myriam
dc.contributor.authorFranke, Barbara
dc.contributor.authorDebette, Stéphanie
dc.contributor.authorMedland, Sarah E
dc.contributor.authorIkram, M Arfan
dc.contributor.authorThompson, Paul M
dc.date.accessioned2018-09-20T15:58:58Z
dc.date.available2018-09-20T15:58:58Z
dc.date.issued2016-10-03
dc.identifier.citationAdams, Hieab H H; Hibar, Derrek P; Chouraki, Vincent; Stein, Jason L; Nyquist, Paul A; Rentería, Miguel E; Trompet, Stella; Arias-Vasquez, Alejandro; Seshadri, Sudha; Desrivières, Sylvane; Beecham, Ashley H; Jahanshad, Neda; Wittfeld, Katharina; Van der Lee, Sven J; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S; Armstrong, Nicola J; Athanasiu, Lavinia; Axelsson, Tomas; Beiser, Alexa; Bernard, Manon; Bis, Joshua C; Blanken, Laura M E; Blanton, Susan H; Bohlken, Marc M; Boks, Marco P; Bralten, Janita; Brickman, Adam M; Carmichael, Owen; Chakravarty, M Mallar; Chauhan, Ganesh; Chen, Qiang; Ching, Christopher R K; Cuellar-Partida, Gabriel; Braber, Anouk Den; Doan, Nhat Trung; Ehrlich, Stefan; Filippi, Irina; Ge, Tian; Giddaluru, Sudheer; Goldman, Aaron L; Gottesman, Rebecca F; Greven, Corina U; Grimm, Oliver; Griswold, Michael E; Guadalupe, Tulio; Hass, Johanna; Haukvik, Unn K; Hilal, Saima; Hofer, Edith; Hoehn, David; Holmes, Avram J; Hoogman, Martine; Janowitz, Deborah; Jia, Tianye; Kasperaviciute, Dalia; Kim, Sungeun; Klein, Marieke; Kraemer, Bernd; Lee, Phil H; Liao, Jiemin; Liewald, David C M; Lopez, Lorna M; Luciano, Michelle; Macare, Christine; Marquand, Andre; Matarin, Mar; Mather, Karen A; Mattheisen, Manuel; Mazoyer, Bernard; McKay, David R; McWhirter, Rebekah; Milaneschi, Yuri; Mirza-Schreiber, Nazanin; Muetzel, Ryan L; Maniega, Susana Muñoz; Nho, Kwangsik; Nugent, Allison C; Loohuis, Loes M Olde; Oosterlaan, Jaap; Papmeyer, Martina; Pappa, Irene; Pirpamer, Lukas; Pudas, Sara; Pütz, Benno; Rajan, Kumar B; Ramasamy, Adaikalavan; Richards, Jennifer S; Risacher, Shannon L; Roiz-Santiañez, Roberto; Rommelse, Nanda; Rose, Emma J; Royle, Natalie A; Rundek, Tatjana; Sämann, Philipp G; Satizabal, Claudia L; Schmaal, Lianne; Schork, Andrew J; Shen, Li; Shin, Jean; Shumskaya, Elena; Smith, Albert V; Sprooten, Emma; Strike, Lachlan T; Teumer, Alexander; Thomson, Russell; Tordesillas-Gutierrez, Diana; Toro, Roberto; Trabzuni, Daniah; Vaidya, Dhananjay; Van der Grond, Jeroen; Van der Meer, Dennis; Van Donkelaar, Marjolein M J; Van Eijk, Kristel R; Van Erp, Theo G M; Van Rooij, Daan; Walton, Esther; Westlye, Lars T; Whelan, Christopher D; Windham, Beverly G; Winkler, Anderson M; Woldehawariat, Girma; Wolf, Christiane; Wolfers, Thomas; Xu, Bing; Yanek, Lisa R; Yang, Jingyun; Zijdenbos, Alex; Zwiers, Marcel P; Agartz, Ingrid; Aggarwal, Neelum T; Almasy, Laura; Ames, David; Amouyel, Philippe; Andreassen, Ole A; Arepalli, Sampath; Assareh, Amelia A; Barral, Sandra; Bastin, Mark E; Becker, Diane M; Becker, James T; Bennett, David A; Blangero, John; van Bokhoven, Hans; Boomsma, Dorret I; Brodaty, Henry; Brouwer, Rachel M; Brunner, Han G; Buckner, Randy L; Buitelaar, Jan K; Bulayeva, Kazima B; Cahn, Wiepke; Calhoun, Vince D; Cannon, Dara M; Cavalleri, Gianpiero L; Chen, Christopher; Cheng, Ching-Yu; Cichon, Sven; Cookson, Mark R; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E; Czisch, Michael; Dale, Anders M; Davies, Gareth E; De Geus, Eco J C; De Jager, Philip L; de Zubicaray, Greig I; Delanty, Norman; Depondt, Chantal; DeStefano, Anita L; Dillman, Allissa; Djurovic, Srdjan; Donohoe, Gary; Drevets, Wayne C; Duggirala, Ravi; Dyer, Thomas D; Erk, Susanne; Espeseth, Thomas; Evans, Denis A; Fedko, Iryna O; Fernández, Guillén; Ferrucci, Luigi; Fisher, Simon E; Fleischman, Debra A; Ford, Ian; Foroud, Tatiana M; Fox, Peter T; Francks, Clyde; Fukunaga, Masaki; Gibbs, J Raphael; Glahn, David C; Gollub, Randy L; Göring, Harald H H; Grabe, Hans J; Green, Robert C; Gruber, Oliver; Gudnason, Vilmundur; Guelfi, Sebastian; Hansell, Narelle K; Hardy, John; Hartman, Catharina A; Hashimoto, Ryota; Hegenscheid, Katrin; Heinz, Andreas; Le Hellard, Stephanie; Hernandez, Dena G; Heslenfeld, Dirk J; Ho, Beng-Choon; Hoekstra, Pieter J; Hoffmann, Wolfgang; Hofman, Albert; Holsboer, Florian; Homuth, Georg; Hosten, Norbert; Hottenga, Jouke-Jan; Pol, Hilleke E Hulshoff; Ikeda, Masashi; Ikram, M Kamran; Jack, Clifford R; Jenkinson, Mark; Johnson, Robert; Jönsson, Erik G; Jukema, J Wouter; Kahn, René S; Kanai, Ryota; Kloszewska, Iwona; Knopman, David S; Kochunov, Peter; Kwok, John B; Lawrie, Stephen M; Lemaître, Hervé; Liu, Xinmin; Longo, Dan L; Longstreth, W T; Lopez, Oscar L; Lovestone, Simon; Martinez, Oliver; Martinot, Jean-Luc; Mattay, Venkata S; McDonald, Colm; McIntosh, Andrew M; McMahon, Katie L; McMahon, Francis J; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Mohnke, Sebastian; Montgomery, Grant W; Morris, Derek W; Mosley, Thomas H; Mühleisen, Thomas W; Müller-Myhsok, Bertram; Nalls, Michael A; Nauck, Matthias; Nichols, Thomas E; Niessen, Wiro J; Nöthen, Markus M; Nyberg, Lars; Ohi, Kazutaka; Olvera, Rene L; Ophoff, Roel A; Pandolfo, Massimo; Paus, Tomas; Pausova, Zdenka; Penninx, Brenda W J H; Pike, G Bruce; Potkin, Steven G; Psaty, Bruce M; Reppermund, Simone; Rietschel, Marcella; Roffman, Joshua L; Romanczuk-Seiferth, Nina; Rotter, Jerome I; Ryten, Mina; Sacco, Ralph L; Sachdev, Perminder S; Saykin, Andrew J; Schmidt, Reinhold; Schofield, Peter R; Sigurdsson, Sigurdur; Simmons, Andy; Singleton, Andrew; Sisodiya, Sanjay M; Smith, Colin; Smoller, Jordan W; Soininen, Hilkka; Srikanth, Velandai; Steen, Vidar M; Stott, David J; Sussmann, Jessika E; Thalamuthu, Anbupalam; Tiemeier, Henning; Toga, Arthur W; Traynor, Bryan J; Troncoso, Juan; Turner, Jessica A; Tzourio, Christophe; Uitterlinden, Andre G; Hernández, Maria C Valdés; Van der Brug, Marcel; Van der Lugt, Aad; Van der Wee, Nic J A; Van Duijn, Cornelia M; Van Haren, Neeltje E M; Van ′t Ent, Dennis; Van Tol, Marie-Jose; Vardarajan, Badri N; Veltman, Dick J; Vernooij, Meike W; Völzke, Henry; Walter, Henrik; Wardlaw, Joanna M; Wassink, Thomas H; Weale, Michael E; Weinberger, Daniel R; Weiner, Michael W; Wen, Wei; Westman, Eric; White, Tonya; Wong, Tien Y; Wright, Clinton B; Zielke, H Ronald; Zonderman, Alan B; Deary, Ian J; DeCarli, Charles; Schmidt, Helena; Martin, Nicholas G; De Craen, Anton J M; Wright, Margaret J; Launer, Lenore J; Schumann, Gunter; Fornage, Myriam; Franke, Barbara; Debette, Stéphanie; Medland, Sarah E; Ikram, M Arfan; Thompson, Paul M (2016). Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature Neuroscience 19 (12), 1569-1582
dc.identifier.issn1097-6256,1546-1726
dc.identifier.urihttp://hdl.handle.net/10379/10122
dc.description.abstractIntracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (rho(genetic) = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (N-combined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits.
dc.publisherSpringer Nature
dc.relation.ispartofNature Neuroscience
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectalzheimers-disease
dc.subjectcommon variants
dc.subject17q21.31 microdeletion
dc.subjectparkinsons-disease
dc.subjecthead circumference
dc.subjectbrain size
dc.subjectigf-i
dc.subjectmetaanalysis
dc.subjectconsortium
dc.subjectheight
dc.titleNovel genetic loci underlying human intracranial volume identified through genome-wide association
dc.typeArticle
dc.identifier.doi10.1038/nn.4398
dc.local.publishedsourcehttp://pubman.mpdl.mpg.de/pubman/item/escidoc:2346285/component/escidoc:2376810/Adams_etal_2016.pdf
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