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Leptin modifies the prosecretory and prokinetic effects of the inflammatory cytokine interleukin-6 on colonic function in sprague-dawley rats
(Wiley-Blackwell, 2016-11-11)
In addition to its role in regulating energy homeostasis, the adipokine leptin modifies gastrointestinal (GI) function. Indeed, leptin-resistant obese humans and leptin-deficient obese mice exhibit altered GI motility. In ...
Unique glycosignature for intervertebral disc and articular cartilage cells and tissues in immaturity and maturity
(Springer Nature, 2016-03-11)
In this study, on/off markers for intervertebral disc (IVD) and articular cartilage (AC) cells (chondrocytes) and distinct glycoprofiles of cell and tissue-types were identified from immaturity to maturity. Three and eleven ...
Biomaterial constructs for delivery of multiple therapeutic genes: a spatiotemporal evaluation of efficacy using molecular beacons
(Public Library of Science (PLoS), 2013-06-03)
Gene therapy is emerging as a potential therapeutic approach for cardiovascular pathogenesis. An appropriate therapy may require multiple genes to enhance therapeutic outcome by modulating inflammatory response and ...
Subclinical detection of diabetic cardiomyopathy with micrornas: challenges and perspectives
(Hindawi Limited, 2016-01-01)
The prevalence of cardiac diabetic diseases has been increased around the world, being the most common cause of death and disability among diabetic patients. In particular, diabetic cardiomyopathy is characterized with a ...
Gene-eluting stents: adenovirus-mediated delivery of enos to the blood vessel wall accelerates re-endothelialization and inhibits restenosis
(Elsevier BV, 2008-10-01)
Drug-eluting stents for coronary artery disease results in inhibition of smooth muscle cell (SMC) and endothelial cells which may increase the risk of stent thrombosis. In this study, we attempted to enhance re-endothelialization ...
Evolution of a research field—a micro (rna) example
(PeerJ, 2015-03-17)
Background. Every new scientific field can be traced back to a single, seminal publication. Therefore, a bibliometric analysis can yield significant insights into the history and potential future of a research field. This ...
Cutting edge: il-7 regulates the peripheral pool of adult ror + lymphoid tissue inducer cells
(The American Association of Immunologists, 2009-07-27)
During fetal life, CD4(+)CD3(-) lymphoid tissue inducer (LTi) cells are required for lymph node and Peyer's patch development in mice. In adult animals, CD4(+) CD3(-) cells are found in low numbers in lymphoid organs. ...
Development of a cucumis sativus tilling platform for forward and reverse genetics
(Public Library of Science (PLoS), 2014-05-16)
Background: Cucumber (Cucumis sativus) belongs to the Cucurbitaceae family that includes more than 800 species. The cucumber genome has been recently sequenced and annotated. Transcriptomics and genome sequencing of many ...
Loss of sigb in listeria monocytogenes strains egd-e and 10403s confers hyperresistance to hydrogen peroxide in stationary phase under aerobic conditions
(American Society for Microbiology, 2016-05-20)
SigB is the main stress gene regulator in Listeria monocytogenes affecting the expression of more than 150 genes and thus contributing to multiple-stress resistance. Despite its clear role in most stresses, its role in ...
Migrastatin analogues inhibit canine mammary cancer cell migration and invasion
(Public Library of Science (PLoS), 2013-10-08)
Background: Cancer spread to other organs is the main cause of death of oncological patients. Migration of cancer cells from a primary tumour is the crucial step in the complex process of metastasis, therefore blocking ...